ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04320.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTEvoked potentials from the human spinal cord were studied in 39 normal volunteers. Intrathecal recordings from lower cervical and lower thoracic intervertebral levels were made after the supramaximal stimulation of the median, ulnar and posterior tibial nerves, respectively. It was shown that the segmental cord potentials varied in shape and size according to the spatial relationship between the position of the electrode tip and the spinal cord and roots within the vertebral canal. Three main types of segmental evoked responses were obtained. One of them was recorded behind the cord dorsum and around the midline, and was composed of fast, sharp early, and slow, late components. This was called a CD potential and its first component was related to the activity of the ascending dorsal funiculus fibres. the second evoked response was the DR potential, and this triphasic compound action potential of very high amplitude and longer duration had no remarkable late component. It was recorded when the tip of the intrathecal electrode was lateral to the midline within the vertebral canal, and was then related mostly to activity of the spinal roots. Another kind of potential was called PH potential. It had a very small triphasic spike and two later components with prominent negativities being higher than the first spike. This potential might be related to the electrode tip position facing, and close to, the posterior horn of the spinal gray matter. Late components of the segmental evoked potentials were related to the pre‐ and post synaptic activity of the horizontally oriented fibres within the segmental gray matter of the posterior hor

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04321.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe propagation velocity of the ascending volleys along the dorsal funiculus of the human spinal cord was studied in 31 normal volunteers. Intrathecal recordings from lower cervical and lower thoracic intervertebral levels were made after the supramaximal stimulation of the posterior tibial nerves. When the electrode tip was behind the cord dorsum at the cervical level, it was easily possible to obtain very clear triphasic compound action potential on stimulation of the posterior tibial nerve of one leg or both legs. This “Tractus Potential” was found to originate mainly from the dorsal funiculus fibres, i.e. Fasciculus gracilis. the maximal conduction velocity of the ascending afferent volley from the leg was then calculated to be, on average, 37 meters/sec between lumbar and cervical spinal enlargements. Intrathecal stimulation and recording of the spinal cord gave the distinct triphasic wave with low threshold. This was also found to be related to dorsal funiculus activity. In these intraspinal stimulations and recordings, very early small and some late long‐lasting deflections appeared, especially in the lateral position of the intrathecal elec

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04322.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTSerum levels of IgE, other immunoglobulins and C'3 were measured in 36 MS patients, and the results compared with those of 40 age‐ and sexmatched patients hospitalized on Neurology Service. Diagnoses among controls included cerebral infarction, cervical spondylosis, nonmigrainous headache, seizure disorders and peripheral neuropathy. Six patients in the MS group and seven in the non‐MS group had a past history of allergy to food, drugs, dust or other substances. IgE levels were measured by double‐antibody radioimmunoassay. Other immunoglobulins (G, M, D and A) and C'3were quantitated by Mancini's method. Results indicate that the median IgE and C'3levels of MS patients were slightly lower than those for non‐MS subjects. Concentrations of other immunoglobulins were similar for the two groups. CSF samples from 12 MS and five non‐MS patients were studied and none of these contained measureable (>7.5 U/ml) IgE. In view of:1) recent‐reports deseribing mast cells in MS plaques, 2) the suggested role of biogenic amines in the pathogenesis of demyelinating diseases, and 3) because IgE exists in free and cell bound state, it is suggested that tissue surveys of MS plaques for IgE deposits similar to those seen in glomeruli in nephrotic syndromes may provide a clue to the pathoge

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04323.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTWith the macrophage electrophoretic mobility (MEM) test of Field&Caspary, Iymphocyte sensitization to thyroid antigen (F1‐fraction) is demonstrable in all subjects‐multiple sclerosis (MS) patients, those with other (destructive) neurological diseases (OND) and normals. the MEM‐LAD test enables a further differentiation to be made in neurological patients compared to normals: Linoleic acid inhibits the positive result by about 95 per cent in the case of MS, 58 per cent in normals and 45 per cent in OND. the high reduction appears to be a characteristic of MS. It is seen at all stages and in all forms of the disease and is not materially influenced by moderate immunosuppressive therapy. the mothers of MS patients show an intermediate result of about 78 per cent, suggesting a familial (genetic) background to the metabolic phenomenon described here; there is, however, evidence of an added exogenic factor for the development of the disease. the theoretical basis of the LAD test suggests further therapeutic trials of linoleic acid in treatment

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04324.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACT281 histologically verified brain tumours in children were revised and reclassified according to degree of histological malignancy. Survival graphs based on 100 per cent follow‐up after 15–40 years show that, of those who survived for more than 1 month after diagnosis and possible operation, 40 per cent were still alive more than 15 years later. There was a clear correlation between survival and degree of malignancy. Sixty‐five per cent of those with tumours of malignancy grade I and only 3 per cent of those with malignancy grade IV were alive after 15

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04325.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

ABSTRACTThe prognostic influence of subfebrility and fever during the first week after an ischaemic cerebral stroke was analysed retrospectively in 110 patients with varying neurological disabilities. the results indicate that fever, and even subfebrility, carry a bad prognosis with respect to residual symptoms. It is concluded that fever and subfebrility, irrespective of their genesis, should be intensely combated during the early stages of an ischaemic stroke.

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04326.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

A. Matthes: Epilepsie. Diagnostik und Therapie für Klinik und Praxis.Ann Silver: the Biology of Cholinesterase.Alan G. Hardy&Alain B. Rossier: Spinal Cord Injuries

ISSN:0001-6314    

DOI:10.1111/j.1600-0404.1976.tb04327.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY