摘要:

AbstractAn analysis of the complex NMR spectrum of 2‐pyrone is presented and the spectra of a series of variously substituted 2‐pyrones and 5,6‐dihydro‐2‐pyrones are discussed. It is demonstrated that NMR spectroscopy affords a convenient and reliable method of assigning the position of substituents on the 2‐pyr

ISSN:0022-152X    

DOI:10.1002/jhet.5570060101

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractFrom the reaction of benzotriazoles with 2,3‐dihydro‐4H‐pyrane and 2‐acetoxymethyl‐3,4‐dihydro‐2H‐pyrane the corresponding 1‐(2‐tetrahydropyranyl)benzotriazole andcis‐and trans‐1‐(6‐acetoxymethyl‐2‐tetrahydropyranyl)benzotriazole derivatives were obtained. The structures and conformations of these compounds were

ISSN:0022-152X    

DOI:10.1002/jhet.5570060102

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractThe reaction of homophthalic anhydride with hydrazine and a number of substituted hydrazines has been investigated. Only in the case of the reaction of homophthalic anhydride and 1,2‐dimethylhydrazine has a diazepine been isolated. The previously reported (2) diazepine from homophthalic anhydride and hydrazine appears to be a product resulting from the reaction of twomolec of homophthalic anhydride with one mole of hydrazin

ISSN:0022-152X    

DOI:10.1002/jhet.5570060103

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractThe acylation of 4‐hydroxy‐6‐melhyl‐2‐pyrone (1) and 4‐hydroxy‐6‐phenyl‐2‐pyrone (XXII) with aliphatic acid anhydrides, or with aliphatic acid chlorides in trifluoroacetic acid, has been found to product; first the corresponding ester, which then rearranges, partially or wholly, depending on the conditions and on the nature of the acyl moiety, to form the corresponding 3‐acylpyrone. With aromatic acid chlorides in pyridine or in trichloroacetic acid only the corresponding ester was obtained. These esters, however, could be rearranged to the corresponding 3‐acylpyrones with aluminum chloride. Acetoaeetylation of 1 and 4‐hydroxycoumarin (XXIX) with diketene gave, in both cases, the

ISSN:0022-152X    

DOI:10.1002/jhet.5570060104

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractPurine‐8‐thione (1) is acylated on nitrogen, not on sulfur as was previously reported. Thus, the reactions of1with ethyl chloroformate and with acetic anhydride yield, respectively, ethyl purine‐8‐thione‐9(7)‐carboxylate (3) and9(7)acetylpurine‐8‐thione (7) as shown by independent synthesis and spectra. In like manner, benzimidazole‐2‐thione (10) reacts with acetic anhydride, ethyl chloroformate, benzoyl chloride, and cyclohexyl isocyanate to yield the correspondingN‐acylated derivatives. In addition,10yields 1,3‐dibenzoylbenzimidazole‐2‐thione on treatment with 2 equi

ISSN:0022-152X    

DOI:10.1002/jhet.5570060105

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

Abstract2,2‐Difluoro‐4‐methylnaphtho[l,2‐e]‐l,3,2‐dioxaborin (1) and its [2,1‐e]isomer (2) react with equimolecular quantities of carbonyl compounds, giving colored ethylenic derivatives. With aniline,1and2give the corresponding oxazaborins21and22. The structures of1and2

ISSN:0022-152X    

DOI:10.1002/jhet.5570060106

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractAdducts formed from benzoyl isothiocyanate and l‐morpholinocyclopentene or β‐(N,N‐diethylamino)styrene and that prepared from acetyl isothiocyanate and l‐pyrrolidinoeyclopen‐tene gave 4‐pyrimidinethiones when treated with primary amines or ammonia. In some cases intermediates, the products of amine exchange, were isolated. These intermediates were readily cyclized to 4‐pyrimidinethiones with

ISSN:0022-152X    

DOI:10.1002/jhet.5570060107

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractA modified synthesis of pentazocine, l,2,3,4,5,6‐hexahydro‐8‐hydroxy‐2,6‐methano‐6, H‐dimethyl‐3‐(3‐methyl‐2‐butenyl)‐3‐benzazocine (III), has been achieved and catalytic hydro‐genation has been found to be effective for the debenzylation

ISSN:0022-152X    

DOI:10.1002/jhet.5570060108

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractIn order to examine the total syntheses of ochotensine (1) and ochotensimine (II), one of the isomers, iso‐ochotensine (III), was synthesized as a preliminary experiment. Namely, Wittig reaction of VI, followed by treatment with sodium bicarbonate solution, gave the expected compound, 7‐ethoxycarbonyl‐3‐ethoxycarbonyloxy‐2‐methoxy‐13‐methyIene‐10,11‐methyIene‐dioxyochotensinan (VII) which was reduced with lithium aluminum hydride to give III. This was also obtained by methylation of 3‐hydroxy‐2‐methoxy‐13‐methylene‐10,11

ISSN:0022-152X    

DOI:10.1002/jhet.5570060109

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY

摘要:

AbstractHydrogen, as well as the halogen atom, at the 4 or 5 position in some 5‐ and 4‐nitroimidazoles were displaced by various nucleophiles such as the amino, cyano, hydroxy, and alkoxy groups. The greater reactivity of the departing group in the 4 position, which was regularly observed, is ascribed to the double activating effect of the azo and nitro groups. Cyanide ion in alcoholic solution reacted peculiarly with both 4‐ and 5‐nitroimidazoles givingo‐cyanoazoxyimidazoles as the only products. In some of the nucleophilic displacements at the 4 position of 5‐nitroimidazoles the formation of intermediate S̀‐complexe

ISSN:0022-152X    

DOI:10.1002/jhet.5570060110

出版商:Wiley‐Blackwell    

年代:1969

数据来源: WILEY