摘要:

AbstractThe correct structure of the reported 3‐aziridinyl‐6‐chloropyridazine was found to be 3‐[β‐(1‐aziridinyl)ethylamino]‐6‐chloropyridazine, which was confirmed by n. m. r. studies. The relative ease of nucleophilic displacement of a methylsulfonyl group versus a chloro group in equivalent positions on a pyridazine or a pyrimidine ring was compared. It was observed that the chloro rather than the methylsulfonyl group was preferentially replaced, as illustrated by substitution studies of 3‐chloro‐6‐methylsulfonylpyridazine and 4‐chloro‐

ISSN:0022-152X    

DOI:10.1002/jhet.5570010101

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractOxidation of amodiaquine with perbenzoic acid gave amodiaquine N‐α‐oxide, whereas N4‐methylamodiaquine and amodiaquine 1‐oxide afforded N4‐methylamodiaquine N‐α,1‐dioxide and amodiaquine N‐α, 1‐dioxide, respectively. Amodiaquine 1‐oxide,O‐methyl‐amodiaquine 1‐oxide, oxychloroquine 1‐oxide, and a variety of other 4 ‐ (7‐chloro‐4‐quinolylamino)‐α‐dialkylamino‐o‐cresol 1‐oxides and 7‐chloro‐4‐[(mono‐ and dialkylamino)‐alkylamino]quinoline 1‐oxides were prepared by the condensation of 4, 7‐dichloroquinoline 1‐oxide with a 4‐amino‐α‐(dialkylamino)‐o‐cresol, N‐α, N‐α‐diethyl‐6‐methoxytoluene‐α, ‐3‐diamine, or a mono‐ or dialkylaminoalkylamine in phenol or aqueous ethanol. N4‐Methyl‐amodiaquine was synthesized fromp‐ [(7‐chloro‐4‐quinolyl)methylamino]phenol,

ISSN:0022-152X    

DOI:10.1002/jhet.5570010102

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractA plan of approach to novel 8‐azasteroids was tested with suitable model compounds to determine its feasibility. The results of these experiments are describe

ISSN:0022-152X    

DOI:10.1002/jhet.5570010103

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractThe crystal and molecular structure of 8, 8‐dimethyl‐8‐azoniabicyclo[5.1. 0]octane iodide has been elucidated. The aziridine ring is bridgedcisto the cycloheptane ring. The cycloheptane ring has been shown to have a distorted chair conformation. No close trans‐annular hydrogen distances have been observed. The compound crystallizes in the space group Pna21with unit cell dimensions a = 17.31, b= 8.58 and c=7.56Å. The final value of R=Σ ‖ Fo| ‐ | Fc‖/Σ| Fo| is 0.145 for the 734 obse

ISSN:0022-152X    

DOI:10.1002/jhet.5570010104

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractEs wird über die erstmals gelungenen Synthesen der beiden möglichen O‐ und N‐Gluco‐side eines 7‐Hydroxypteridins berichtet. Die Direktglucosidierung des 4‐Dimethylamino‐7‐hydroxypteridins mit Acetobromglucose führte zum 4‐Dimethylamino‐7‐(2. 3.4. 6‐tetra‐acetyl‐β‐D‐glucopyranosyloxy)pteridin während die Darstellung des isomeren 8‐(2.3.4.6‐Tetraacetyl‐β‐D‐glucopyranosyl)‐4‐dimethylamino ‐7‐oxo‐ dihydropteridins nur ausgehend vom 4‐Amino‐6‐dimethylaminopyrimidin und Glucosidierung auf der Pyrimidinstufe re‐alisiert werden konnte. Die Pteridin‐glucoside wurden durch UV‐A

ISSN:0022-152X    

DOI:10.1002/jhet.5570010105

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractSeveral fluorinated derivatives of phenarsazine and benzophenarsazines, bearing various additional substituents in their molecule, have been prepared from arsenic trichloride and the appropriate N, N'‐diarylamines. These compounds showed strong irritant and sternutatory propertie

ISSN:0022-152X    

DOI:10.1002/jhet.5570010106

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractThrough cyclization of suitably substituted 1‐benzyl‐2 ‐ (1, 3‐ dioxolan‐2‐yl)pyridinium salts, ačeridizinium salts having nitro, carboxyl or sulfo substituents have been prepared. The 9‐sulfo aeridizinium derivative exists as a remarkably

ISSN:0022-152X    

DOI:10.1002/jhet.5570010107

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractNuclear magnetic resonance spectra have been utilized in several instances to distinguish between ring closure to a derivative of imidazo[1, 2‐c]pyrimidine or pyrrolo[2, 3‐d]pyrimidine. N.m.r. studies have also been employed to select Vc as the most probable structure for 5‐methylthio‐2, 7‐imidazo[1, 2‐c]pyrimidinedione. Ultraviolet absorption spectra and n.m.r. studies in deuterium oxide support the conclusion that there is more aromaticity in the anion V g than in the neutral molecule. The present work describes several new synthetic routes to derivatives of imidazo[1,2‐c]pyrimidine and pyrrolo[2,3

ISSN:0022-152X    

DOI:10.1002/jhet.5570010108

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractThe adenine analog, 7‐aminoimidazo[4,5‐c]pyridazine (XII) and three other members of this previously unknown ring system have been prepared. The adenine analog, 8‐amino‐tetrazolo[1,5‐b]pyridazine (I) has also been prepared together with three other compounds in this ring system. The novel displacement of halogen in nitrogen heterocycles with phosphorus pentasulfide has been

ISSN:0022-152X    

DOI:10.1002/jhet.5570010109

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY

摘要:

AbstractThe preparation and properties of a number of new N‐acylcaprolactams are described. These compounds were found to be catalysts for the anionic polymerization of caprolacta

ISSN:0022-152X    

DOI:10.1002/jhet.5570010110

出版商:Wiley‐Blackwell    

年代:1964

数据来源: WILEY