摘要:

AbstractMacrocyelic polyether sulfides have been prepared by reacting an oligoethylene glycol dichloride with a dithiol or sodium sulfide in ethanol. The trivial naming system for these compounds is an extension of the trivial crown nomenclature (5). A thia prefix is used to show that sulfur atoms have replaced ether oxygen atoms in the polyether ring. The following new compounds were prepared: 1‐thia‐(15‐crown‐5) (II) 1,4‐dithia‐(15‐crown‐5) (III) 1,7‐dithia‐(15‐crown‐5) (IV) 1,4‐dithia‐(12‐crown‐4) (VII) 1,4,7‐trithia‐(12‐crown‐4) (VIII) 1‐thia‐(9‐crown‐3) (IX) and 1,4‐dithia‐(9‐crown‐3) (X). Four other previously reported maerocyelic polyether sulfides were also prepared. The symmetry of the nmr spectra of these compound

ISSN:0022-152X    

DOI:10.1002/jhet.5570100101

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThiazolo[3,2‐d] tetrazolium salts were obtained by treatment of 5‐mercapto‐1‐phenyl‐1,2,3,4‐tetrazole with α‐bromo ketones followed by cyclodehydration. The spectral properties of the salts and the β‐keto sulfide precursors

ISSN:0022-152X    

DOI:10.1002/jhet.5570100102

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

Abstract4‐Sul>stituted‐1,2,3‐thiadiazoles were found to react with base to form cis‐2,ω‐disubstituted‐1,4‐dithialulvenes. The mechanism lor the stereoselective formation of the produc

ISSN:0022-152X    

DOI:10.1002/jhet.5570100103

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractCondensation of ethyl 2,4‐dioxo‐6‐phenylhex‐5‐enoates (I; R = H, I; R = Me, I, R = Ph) with various hydrazines yielded ethyl 5‐styrylpyrazole‐3‐carboxylates (III), which were hydrolyzed to the acids (IV), and ozonized to 5‐keto pyrazole esters (VI) and acids (VII). Reduction of the 5‐formylpyrazoles (VI; R = II) with borohydride afforded the 5‐hydroxymethyl derivatives (VIII). The same 2,4‐dioxohexenoates (I) when treated with o‐phenylenediamine gave 2‐oxy‐quinoxalines (V; R = H, V; R = Me, V; R = Ph). The uv spectra data

ISSN:0022-152X    

DOI:10.1002/jhet.5570100104

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractHomoveratrylamine was condensed with 1‐cyanocyclopentene to afford the corresponding 2‐cyano‐N‐(3,4‐dimethoxyphenethyl)cyclopentylamine (III), which was ethoxycarbonylated with ethyl chlorocarbonate to give thetrans‐urethan (IVt) (major product) and thecis‐urethan (IVc) which could be separated through a silica gel column. Thecis‐urethan was converted to thetrans‐urethan by the action of a catalytic amount of sodium ethoxide. Based upon general considerations of nucleophilic addition such as the Michael type reaction, the physical data obtained, and the difference in ease of cyclization of the 2‐aminomethyl‐N‐ethoxycarbonyl‐.N‐homoveratrylcyclopentylamines (Vt and Vc) to the corresponding cyclic ureas (Vlt and VIc), it was concluded that the major product was thetransand the minor thecisisomer.The cyclized compounds, Vlt and VIc, were subsequently submitted to the Bischler‐Napieralski reaction furnishing the corresponding isoquinoline derivatives respectively. Thus the authors established a skeletal synthesis of the title compound, a 8,11‐diazasteroid, and its stereochemical configuration at the C

ISSN:0022-152X    

DOI:10.1002/jhet.5570100105

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractTreatment of 1,2,5,6‐tetrahydro‐2‐(4‐hydroxy‐ and/or 4‐methoxybenzyl)‐3,4‐dimethyl‐I‐(3‐methyl‐2‐butenyl)pyridines (IV and V) and 2‐(4‐methoxybenzyl)‐3,4‐dimethyl‐1‐(3‐methyl‐2‐butenyl)‐4‐piperidinol (X) with acid afforded 9‐(4‐hydroxy‐ and/or 4‐methoxybenzyl)‐4,4,5,6‐tetramethyl‐1‐azabicyelo[3,3,1]non‐6‐ene (XIII and XIV). In contrast, the corresponding 1‐allyl‐substituted derivatives VI, VII, and XI were converted into the expected 3‐allyl‐1,2,3,4,5,6‐hexahydro‐8

ISSN:0022-152X    

DOI:10.1002/jhet.5570100106

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractA benzyne type reaction of 1‐bromo‐3,4‐dimethoxybenzene (V) with 3,4‐dihydro‐6,7‐methylenedioxy‐I(2H)naphthalenone (VI) gave the tetralone derivative VII, which was converted into the amine IXviathe oxime VIII. A Mannich reaction of IX afforded the benzo[c]phen‐anthridine II which was then transformed into oxynitidine (I) an

ISSN:0022-152X    

DOI:10.1002/jhet.5570100107

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

Abstract(±)‐N‐Norgalanthamine (la) and (±)‐N‐norlycoramine (Ib) was synthesized through the phenolie oxidation ofN‐(4‐hydroxyphenethyl)‐2‐bromo‐5‐hydroxy‐4

ISSN:0022-152X    

DOI:10.1002/jhet.5570100108

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe intramolecular nucleophilic cyclization of 4‐(3‐pyridyl)butylamine (4a) to yield 6,7,8,9‐tetrahydro‐5H‐pyrido[2,3‐b]azepine (5) was investigated. Of eleven different alkali metal reagents sodium, sodium hydride, sodium amide, and potassium hydride gave good yields of5. The sodium conditions when applied to 3‐(3‐pyridyl)propylamine (4b) afforded 1,2,3,4‐tetrahydro‐1,8‐naphthyrid

ISSN:0022-152X    

DOI:10.1002/jhet.5570100109

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY

摘要:

AbstractThe complexing ability of derivatives of azobenzene (I) is well known (I) and responsible for the production of a wide variety of dyestuffs and analytical chemicals. While the azo group generally participates in the coordination, the determination of the degree of its interaction is complicated by other functional groups which are also coordinated with the transition metal. In a previous publication (2), we reported the preparation of the silver and palladium complexes of benzo[c]cinnoline (II) and proposed that these results might be used to explain the electron donor properties of azobenzene. We are now reporting the preparation of some additional complexes with ligands containing the azo group.

ISSN:0022-152X    

DOI:10.1002/jhet.5570100110

出版商:Wiley‐Blackwell    

年代:1973

数据来源: WILEY