ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Giant cell arteritis (GCA), the most common form of systemic vasculitis in adults, preferentially involves large and medium-sized arteries in patients over the age of 50. The classic manifestations are headache, jaw claudication, polymyalgia rheumatica (PMR), and visual symptoms, but 40% of patients present with a wide range of occult manifestations. Early diagnosis and treatment with prednisone can prevent blindness, the most feared complication of GCA. The pathogenesis of GCA is T-cell dependent and antigen driven. Clinical subsets of GCA appear to result from variable cytokine expression. The risk of developing thoracic aortic aneurysm is increased more than 17-fold in patients with GCA. GCA can also involve large arteries, especially the subclavian and axillary arteries. Color Doppler ultrasound, magnetic resonance imaging, and positron-emission tomography scanning are providing insights into the extent and pathogenesis of the disease but have not replaced temporal artery biopsy as the gold standard for securing the diagnosis. Two recently completed double-blind, placebo-controlled trials concerning whether methotrexate plus prednisone is more effective than prednisone alone reached conflicting conclusions.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Churg-Strauss syndrome (CSS) is a form of primary vasculitis characterized by allergy and angiitis. In the organ systems involved (lung, heart, peripheral nervous system, and so forth), eosinophilic infiltration can be found. Eosinophilia and normochromic normocytic anemia are leading laboratory findings together with elevated IgE. New seromarkers for the activation of endothelial cells, lymphocytes, and eosinophils (soluble thrombomodulin, soluble interleukin-2 receptor, eosinophil cationic protein) may be able to predict a relapse. Antineutrophil cytoplasmic antibodies are found in only approximately 50% of all patients with CSS, and their diagnostic value is questionable. Etiologically, hyperresponsiveness to an antigenic stimulus seems to underlie the syndrome. In asthmatics, cysteinyl leukotriene receptor type 1 antagonists are reported to trigger the disease. Cytokine profile findings on the cells involved in CSS remain contradictory. Some think CSS may be a Th2-mediated disease; its pathophysiology is not known fully. Interleukin-5 and tumor necrosis factor-&agr; are elevated in serum and fluid of bronchoalveolar lavage, suggesting target cytokines for future treatment protocols. Treatment consists of glucocorticoid monotherapy. Data on outcome and effectiveness is lacking for other immunosuppressive regimens, such as cyclophosphamide or glucocorticoid plus cyclophosphamide. Treatment with interferon-&agr; has been effective in patients refractory to glucocorticoid plus cyclophosphamide.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

There has been a profusion of studies related to the pathogenesis of antineutrophil cytoplasm antibody-associated small vessel vasculitis. Further definition of epitopes on the major antigens, proteinase-3 and myeloperoxidase, has been sought, and intracellular signal transduction pathways after antineutrophil cytoplasm antibody-neutrophil interactions are beginning to be explored. Antineutrophil cytoplasm antibody stimulation of neutrophils has highlighted the functional importance of the accelerated death that follows the initial activation. The consequences of neutrophil and monocyte activation for endothelium and tissue damage continue to point toward an inflammatory process that has become dysregulated. Factors that initiate vasculitis are being identified slowly. The most secure identifiable environmental trigger is the antithyroid drug propylthiouracil. It is likely that environmental factors operate against a background genetic susceptibility, and polymorphisms in genes for proteins associated with inflammation are being tested for possible links with small vessel vasculitides.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

The improvement in survival of the systemic vasculitides with the use of current immunosuppression has heightened awareness of their poor long-term outcome in terms of chronic morbidity and relapse. Assessment of systemic vasculitis is an essential part of its management. Better understanding of the underlying pathophysiology of the antineutrophil cytoplasmic antibody-related vasculitides has resulted in improved assays and may result in more precise serologic assessment of disease. Clinical assessment tools for accurately measuring disease activity and damage have been developed and are reviewed in this article. It is becoming increasingly clear that these clinical tools are practical, effective measures that can assist in the treatment of individual patients and play an important role in clinical trials of systemic vasculitis.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Cryoglobulins are immunogloblulins that persist in the serum, precipitate with cold temperature, and resolubilize when rewarmed. Mixed cryoglobulins, composed of different immunoglobulins, with a monoclonal component in type II and only polyclonal immunoglobulins in type III, are associated with connective tissue, malignant hematologic, or obvious infectious diseases. The syndrome of mixed cryoglobulinemia represents the consequence of an immune complex-type vasculitis. It is characterized by the clinical triad of purpura, arthralgia, and asthenia, and may involve numerous organs, particularly the peripheral nervous system and the kidneys. Mixed cryoglobulinemia frequently is associated with clinical and biologic evidence of liver disease. It seems fairly clear that mixed cryoglobulinemia is often a manifestation of underlying chronic active or persistent hepatitis. In the last 10 years, many studies have demonstrated that infection with hepatitis C virus is involved in the pathogenesis of most mixed cryoglobulinemia vasculitis. This review analyzes the main published data of hepatitis C virus-mixed cryoglobulinemia, the role of liver alterations, the predictive factors associated with mixed cryoglobulin production in hepatitis C virus patients and whether its character is symptomatic, and the different types of vasculitis associated with hepatitis C virus chronic infection and their treatments.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Little is known about pregnancy in patients with vasculitis because of the nature of these diseases and the potential for infertility to occur from effective treatments. However, with the expanding armamentarium of therapeutic options that do not affect reproductive function, it is anticipated that more vasculitis patients will entertain the possibility of conception and consider the outcomes of pregnancy. Relevant issues include the effects of the vasculitis on pregnancy, the effects of the pregnancy on vasculitic disease activity, and the impact of medications used during the peripartum period. Although available data are limited and fall short in many regards, there is support for successful outcomes of pregnancy when conception occurs in disease remission. Maternal and fetal outcome is optimized by the establishment of a multidisciplinary team that can provide preconception evaluation and counseling followed by frequent monitoring throughout the pregnancy and the postpartum period.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Pain is one of the most important and challenging consequences of musculoskeletal disorders. This article examines the role of central nervous system structures in the physiology of pain. It also describes the neuromatrix, a construct that provides a framework for understanding the interaction between physiologic mechanisms and psychosocial factors in the development and maintenance of chronic pain. This construct suggests that behavioral and psychologic interventions may alter the pain experience primarily through their effects on emotional states and cognitive processes. The literature on cognitive-behavioral interventions for patients with rheumatoid arthritis and osteoarthritis indicates that they are well-established treatments for these disorders. However, the efficacy of these interventions for patients with fibromyalgia has not been established. It is anticipated that the development of valid measures of readiness for behavioral change may allow investigators to identify the patients with musculoskeletal disorders who are most likely to benefit from cognitive-behavioral intervention.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID

摘要:

Injection therapies play a major role in the management of various pain conditions. Some injections are relatively simple to perform whereas others are technically demanding with significant risk of mortality and morbidity. Traditional therapies such as intra-articular injections, regional blocks, and trigger-point injections continue to be redefined as we gain a better understanding into the pathophysiology of nociception, with a greater insight into regional anatomy using improved imaging capabilities. Injection therapies are becoming an integral part of the multidisciplinary therapies required to improve and rehabilitate pain patients. The necessity of clinical outcome assessments including functional-based outcomes and cost-effective analysis is becoming more important in the current medical reimbursement environment.

ISSN:1040-8711    

出版商:OVID    

年代:2002

数据来源: OVID