ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Long-term follow-up data indicate that the systemic vasculitides are chronic relapsing diseases with high morbidity. It is therefore of paramount importance to distinguish activity, which requires cytotoxic or immunosuppressive therapy, from damage requiring rehabilitation. Damage due to underlying disease or treatment highlights the need for more effective, less toxic treatment regimens. An integrated package for clinically based assessment of disease activity in systemic vasculitis, the Vasculitis Integrated Assessment Log, has been accepted for further evaluation and implementation by the European Community Study Group for use in therapeutic trials. The added value of serologic tests and inflammatory markers in clinical assessment is becoming more clear, and unsuspected disease activity has been revealed by biopsy and imaging of standard sites or affected areas. Integration of these data should enable characterization of high- and low-risk patient subgroups to determine specific therapies.

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Because of the relative rarity of the conditions, epidemiologic investigation of systemic vasculitis is a challenging prospect. Previous work in this area has been primarily in the form of descriptive studies and therapeutic trials, which have increased awareness of these syndromes among clinicians. However, compared with other diseases, little is known about the epidemiology of the systemic vasculitides. Although significant progress has been made during the past year to estimate incidence and prevalence rates of disease, particularly for giant cell arteritis and Kawasaki disease, further studies are needed to determine risk factors for initial expression and relapses of vasculitis, biologic markers of disease progression, comorbidities, long-term outcomes, and cost of care and disability.

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

The HIV infection epidemic and, with it, the resurgence and emergence of old and new opportunistic microbes, have sparked off a renewed interest in vasculitis associated with infectious agents. Current investigations focus on identification of “newer” infectious agents, unusual clinical manifestations, and methodologic refinement in diagnosis and treatment. This article briefly reviews the background of infection-associated vasculitis and highlights some of the newer and unusual aspects of vasculitis known to be associated with nonviral and viral infections.

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Vasculitides associated with malignancies are infrequent. We can group this syndrome under three broad clinical categories: vasculitide-associated malignancies or true paraneoplastic syndrome, malignancies masquerading as vasculitides, and vasculitides masquerading as malignancies. Recent new etiopathogenic hypotheses are discussed: an immunologic dysregulation with either handling, production, or elimination of circulating immune complexes; an immunogenetic abnormality with autogenes and oncogenes with up- and/or downregulation of cell proliferation through abnormal apoptosis; and direct involvement of a virus such as human T cell lymphotropic virus type I or Epstein-Barr virus. An update on several recently reported associations between vasculitides and malignancies is presented.

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Vasculitis resulting from drug use includes a wide variety of clinical and pathologic conditions that are, in general, empirically defined and poorly understood. Further complicating our grasp of these disorders are ambiguous terms such ashypersensitivity vasculitis, allergic vasculitis, leukocytoclastic vasculitis, serum sickness, and others, which are often used interchangeably without clear definition. The clinical picture varies widely from self-limiting to progressive and even fatal illness. These syndromes have now been reported in association with newer classes of therapeutic agents including biologic response modifiers. Vasculitis affecting the central nervous system may be related to a variety of drugs and remains one of the more important syndrome sets within the spectrum of drug-induced vasculitis. These disorders are clinically important, because removal of the offending drug often is associated with regression of the vasculitic condition.

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

The 5th International Kawasaki Disease Symposium was held in May 1995 in Fukuoka, Japan. No one infectious agent has been found to initiate the syndrome, although the occurrence of Kawasaki disease in epidemics and its resemblance to toxic-shock syndrome make an infectious etiology seem most likely.

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID

摘要:

Rheumatic manifestations of malignancy include a wide spectrum of osteoarticular, muscular, glandular, endocrinologic, and systemic features, posing a therapeutic challenge. The clinician should be aware that Sjögren's syndrome, polymyositisdermatomyositis, rheumatoid and rheumatoid-like arthritis, polymyalgia rheumatica and temporal arteritis, and diverse osteomuscular conditions may be the immunopathogemic features of a neoplasm, the direct consequence of osteomuscular tumors, the effect of tumor-associated hormones, or the consequence of cancer therapy. The principal articles that have appeared in the past year on these associations are discussed. We also review the association of x-ray irradiation and cancer in patients with ankylosing spondylitis.

ISSN:1040-8711    

出版商:OVID    

年代:1996

数据来源: OVID