摘要:

ABSTRACT.Thirty‐three severely mentally retarded children with profond malnutrition and aspiration pneumonitis were treated by gastrostomy and Nissen fundoplication. Early and late complications were 27.3% and 16.6% respectively. Mortality was 9.4%. All surviving patients gained weight. Time required for feeding was greatly, reduced. This study supports earlier operative intervention for the mentally retarded child with gastroesophageal reflux, malnutrition and aspiration pneumoniti

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01337.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Fifty‐eight cases of West syndrome (eight idiopathic, 50 secondary) have been followed‐up for a mean period of 5 years 5 months. The relationship has been studied between intellectual status at the final follow‐up and the following variables: etiology, age of onset, neurological examination and developmental assessment at the onset, CT scan findings, short‐term effect of ACTH treatment, and age of acquiring four developmental milestones (sitting unsupported, walking unsupported, uttering the first specific word and using a sentence of two words).Developmental and/or neurological abnormalities before the onset of the spasms, symptomatic etiology and abnormal CT findings are associated with a low IQ at the final follow‐up.The age for sitting unsupported and for walking unsupported has proved to be not predictive of intellectual outcome, but the speech development data have shown a highly significant relationship with intellectual development.Early identification of the children with mental retardation has turned out to be superior to prediction of normal menta

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01338.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.This paper presents an analysis of the picture which emerged from a study of drug prescribing in a hospital for the mentally handicapped.

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01339.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Nineteen adults with Down's syndrome were studied with the static charge sensitive bed (SCSBl method. A single whole‐night recording was made of each subject. Two different periodic breathing indices (PBIf and PBI%) were calculated from a computerized analysis of these recordings. A polygraphic recording was also made of one subject, a 52‐year‐old male. The EEC, the EOG, the EMG, nasal and oral airflow, and diaphragmatic movement were recorded, the latter with an abdominal strain gauge and with the SCSB‐method simultaneously. Good correlation was found between the recording with the SCSB and the strain gauge. The apnoea index (AI calculated from the polygraphic recording was 23.3, while the PBIf of this patient recorded on another night and analysed automatically was 45 and the PBI% was 78.6. The patient group was divided into those aged 40 or older (n= 10) and those aged 39 or younger (n=9). The mean PBI% of the older group was 24.0 while that of the younger group was 5.4 (t = 2.23; P<0.05). The mean PBIf of the older group was 16.7 and that of the younger was 3.6 (i=2.70; P=<0.02). The mean body mass index (BMI) of the younger group was significantly higher than the mean BMI of the older group. The mean BMI of those patients, whose FBI values were considered to be normal (PBI%<3, PBIf<7), did not significantly differ from the BMI of those patients, whose PBI‐values were abnormal. There were four patients with tonsillar or lingual hypertrophy in the older age group and five in the younger. The mean FBI‐values between those with and those without narrowing of the upper airways did not differ significantly. The study thus indicated that age is the most significant factor favouring the development of periodic breathing during sleep in patients with Down

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01340.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.A 12‐year comparison of changes in the distribution of age, sex and level of functioning, as well as in life expectancy for menially retarded persons in Canadian institutions has been reported. The major findings of the study corroborate, for the most part, studies from other parts of the developed world despite differences in measures of mortality. Several trends have emerged from the data which will have implications for long‐termplann

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01341.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.A cytogenetic survey has been carried out among mentally retarded schoolchildren in the West Midlands Region, England. The conclusions are that the Fragile‐X syndrome is second only to Down's syndrome as a cytogenetic entity contributing to mental handicap among children of school ag

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01342.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.During screening of male individuals for Fragile‐X syndrome in a residential facility for persons with mental retardation, the authors found a 21‐year‐old profoundly retarded man who displayed facial features and behaviour suggestive of Fragile‐X syndrome. The chromosome analysis revealed 47, fra(X)(q27)fra(X)(q27)Y. His physically and intellectually normal sister had 14% of X chromosomes with a fragile site. Her two sons, who were subsequently examined, were found to have Fragile‐X syndrome.Thus, the identification of Fragile‐X syndrome in the proband during the screening process of a large institution led to the investigation of the proband's family and the subsequent diagnosis of Fragile‐X syndrome in the proband's two nephews. The ascertainment of the two affected boys permitted prompt introduction of early intervention and special education services. Genetic counselling of other at‐risk family members

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01343.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Two mentally handicapped dizygotic twin sisters were found to possess the Fragile‐X lesion. They showed different levels of cognitive deficit. The hypothesis that the level of cognitive function in female carriers of the Fragile‐X lesion may be influenced by Lyonization is discussed. The mother of the twins was schizophrenic. Although she was an obligate carrier her psychosis was thought not to be causally connected with the Fragile‐X s

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01344.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Two cases of mentally handicapped patients, who developed delusions of passion, are described. The relationship of these cases to de Clerambault's Syndrome, and their pathogenetic features, are discussed.

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01345.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0964-2633    

DOI:10.1111/j.1365-2788.1987.tb01346.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY