ISSN:0022-3417    

DOI:10.1002/path.1711630102

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

ISSN:0022-3417    

DOI:10.1002/path.1711630103

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractNine patients with t(11;14) and B non‐Hodgkin's lymphomas composed of small to intermediately sized cells with irregular nuclei are described. Immunophenotyping was performed on seven cases, which were M+, D− with light chain restriction, CD5+, CD10−, and CD20+, suggesting that they were non‐follicle centre cell lymphomas. The translocation (11;14) (in three cases the only cytogenetic anomaly) was associated with rearrangement of bcl‐1 in four of the five cases investigated. Translocation (11;14) has been described in an apparently heterogeneous group of low‐grade lymphoid malignancies which we suggest have a non‐follicle centre cell lineage in common. This translocation may be associated with these lymphomas in the same way that t(14; 18) is associated with follicle centre c

ISSN:0022-3417    

DOI:10.1002/path.1711630104

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractA consecutive 10‐year series of 278 soft tissue sarcomas was prospectively graded, using a system based on the number of mitoses and taking into account parameters such as cellularity, anaplasia, necrosis, and histogenetic type and subtype of tumour. Prognostic factors in relation to metastasis‐free survival were studied by uni‐ and multivariate analysis.Fifty‐seven (20·5 per cent) were low‐grade tumours, 43 (15·5 per cent) were intermediate, and 178 (64 per cent) were high grade. High‐grade tumours were divided into two groups; 80 (29 per cent) grade 3A (=5–20 mitoses per 10 high power fields (HPF)) and 78 grade 3B (28 per cent) (=more than 20 mitoses/10 HPF); 10 HPF corresponds to 2·5 mm2. Twenty (7·2 per cent) high‐grade tumours could not be further subdivided.Grading was found to be the prognostic factor associated with the strongest predictive value. Five‐year survival in low‐grade and intermediate tumours (95 and 86 per cent, respectively) differed significantly (P<0·0001) from high grade (50 per cent) and (P= 0·0018) between grade 3A (64 per cent) and grade 3B (41 per cent). Other prognostic indicators of importance in high‐grade tumours were age, local recurrence at presentation (primary operation outside the Centre), and localiza

ISSN:0022-3417    

DOI:10.1002/path.1711630105

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractLangerhans cells (LCs) are dendritic, antigen‐presenting cells found in the epidermis. This study investigates the effect of early breast cancer on the expression of CD1a and S100 antigens by these cells. LCs were counted and expressed as cells/mm of epithelial basement membrane on biopsies from the skin overlying the tumour and from biopsies distant from the tumour. A control study was performed on normal breast skin, not adjacent to a lesion, from women with benign breast disease.The LC count of 18 patients undergoing biopsy for benign breast disease indicated a mean of 26 cells mm [95 percent confidence interval (CI) 23–29] and a S100/CD1a ratio of 70 percent.In 35 cases of early breast cancer, the CD1a‐positive LC count in the epidermis overlying the carcinoma (mean 26/mm; 95 per cent CI 23–29) was similar, but the count made on biopsies distant from the tumour (mean 21/mm; 95 per cent CI 19–23) was significantly smaller. The percentage ratio of S100/CD1a LCs was 71 per cent over the carcinoma and 84 per cent in the distant biopsies.The changes were not associated with the presence of nodal metastases or the oestrogen and progesterone status of the primary tumour.The reduction in LC numbers provides a link between decreased monocyte function and the decreased skin hypersensitivity responses found in patients with brea

ISSN:0022-3417    

DOI:10.1002/path.1711630106

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractThe prognostic significance of nucleolar organizer regions (NORs) in renal cell carcinoma (RCC) was evaluated. NORs were quantified in a series of 182 cases of RCC using the silver‐colloid method. The cases were staged according to Robson's method (48 stage I, 26 stage II, 33 stage III, 75 stage IV) and mean NOR numbers for each tumour were correlated with survival over a 5‐year period. Localized tumours (stages I and II) with low NOR numbers had an almost 100 per cent 5‐year survival. Those patients with clinical evidence of metastases at presentation showed a high mortality, although those with low numbers of NORs had a significantly increased disease‐free interval. Statistical analysis using the log rank test indicated NORs to be a significant predictor of survival over the whole series (P= 0·0001) and within each of Robson's stages (P= 0·0008 stage I,P= 0·0154 stage II,P= 0·0009 stage III,P= 0·0001 stage IV). Analysis of data using Cox's proportional hazard model showed mean NOR numbers to be independent of stage as a predictor

ISSN:0022-3417    

DOI:10.1002/path.1711630107

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractAmong adenoid cystic carcinomas of salivary glands (ACCs), the solid basaloid type has a poor prognosis similar to that of undifferentiated adenocarcinomas. We studied 24 cases in immunohistochemistry using antibodies reactive with keratins of various molecular weights, vimentin, S‐100 protein, and its A and B subunits. Our findings were correlated with the histological pattern and with the variable degree of differentiation of these carcinomas. In comparison with other types of ACC, intermediate filament proteins in this group were weakly expressed. The co‐expression of cytokeratin and vimentin was noted in some cases. Additional features noted were the presence of cribriform cavities associated with solid lobules and areas of necrosis giving a comedocarcinomatous pattern. In these two variants, cells characterized by the dual expression of cytokeratin and S‐100 protein were seen. In the highly malignant anaplastic variety, only a few cells were weakly positive with antisera to cytokeratin and vimentin. This group shows similarities to undifferentiated adenocarcinomas of salivary glands. Such similarities could be explained by the common origin of these tumours from intercalated

ISSN:0022-3417    

DOI:10.1002/path.1711630108

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractThe right testis and epididymis were removed at necropsy from 31 patients who had died with AIDS and examined microscopically. The testes showed interstitial fibrosis in 22 cases, thickening of seminiferous tubule basement membranes in an overlapping 21, and varying degrees of maturation impairment in all. Arrest of spermatogenesis usually occurred at the spermatocyte or spermatid stage. Five epididymides showed an obstructive picture, two with an associated epididymal cytomegalovirus infection. We discuss the possible pathogenesis of the changes in the HIV‐infected male genital system and briefly comment on the clinical implications of our finding

ISSN:0022-3417    

DOI:10.1002/path.1711630109

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractCellular H‐ and M‐type lactate dehydrogenase (LDH) isoenzymes were determined immunohistochemically in a wide range of normal, inflammatory, benign neoplastic, and malignant tissues to assess the possible value of the isoenzymes in tumour diagnosis. Both types of LDH were detected almost ubiquitously in normal tissues. Increased staining intensity of LDH, especially M‐type LDH, was demonstrated in most types of malignant tumours studied. Similar increased staining intensity of the isoenzymes was also noted to parallel the proliferative activity of the cells in non‐neoplastic diseases and benign neoplasms. The results suggest that changes of cellular H‐ and M‐type LDH isoenzymes are not specific for any type of malignant tumours. The increase in cellular H‐ and M‐type LDH isoenzymes appears to be related to proliferation of c

ISSN:0022-3417    

DOI:10.1002/path.1711630110

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY

摘要:

AbstractThirty primary liver neoplasms (16 hepatocellular, nine biliary, and five epithelioid haemangioendotheliomas) were studied for the expression of the general ‘neuroendocrine’ markers, neurone specific enolase (NSE) and protein gene product 9·5 (PGP 9·5). Grimelius silver staining for neurosecretory granules and immunostaining for S100 protein, HMB‐45, vasoactive intestinal polypeptide (VIP), and calcitonin were also performed. Eleven of the 16 hepatocellular carcinomas stained positively for PGP 9·5, four for NSE, six for HMB‐45, and two for S100 protein. Seven exhibited granular staining by the Grimelius method; eight showed immunostaining for VIP, and two for calcitonin. Three of the five haemangioendotheliomas demonstrated positive immunostaining for PGP 9·5, and two for NSE; of the nine biliary carcinomas, two showed staining for PGP 9·5 and NSE, and four contained cells staining with the Grimelius technique. Primary neoplasms of liver may show ‘neuroendocrine’ differentiation and this aspect of their phenotypic expression has to be considered before predicting the site of origin of a tum

ISSN:0022-3417    

DOI:10.1002/path.1711630111

出版商:John Wiley&Sons, Ltd.    

年代:1991

数据来源: WILEY