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1. |
High Hyaluronic Acid and Low Dermatan Sulfate Contents in Human Pulmonary Arteries Compared to in the Aorta |
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Journal of Vascular Research,
Volume 25,
Issue 1,
1988,
Page 1-11
Katsumi Murata,
Y. Yokoyama,
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摘要:
We examined the glycosaminoglycan (GAG) components in human pulmonary arteries compared to those in the aorta. Definite changes in GAG contents and components were found between the pulmonary arteries and the aorta. The GAG content of the aorta was constantly higher than that of the pulmonary artery. As to the components of the arterial GAGs, however, hyaluronic acid comprised significantly higher proportions of total GAGs in the pulmonary arteries than in the aorta, whereas dermatan sulfate showed lower proportions in the pulmonary arteries than in the aorta. These significant differences are possibly due to either the effect of the continuously different blood pressure on the wall of these two types of arterial vessels or to constitutional changes of their fundamental structures associated with atherosclerosis.
ISSN:1018-1172
DOI:10.1159/000158716
出版商:S. Karger AG
年代:1988
数据来源: Karger
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2. |
Evidence that Rabbit125I-Antithrombin III Binds to Proteoheparan Sulphate at the Subendothelium of the Rabbit Aorta in vitro |
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Journal of Vascular Research,
Volume 25,
Issue 1,
1988,
Page 12-27
Mark W. Hatton,
Sue L. Moar,
Mary Richardson,
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摘要:
The endothelium of the rabbit thoracic aorta was removed from the vessel wall by one of two procedures, and the freshly exposed subendothelial surface was used for 125I-antithrombin III binding studies. Pretreatment of the subendothelium with either heparitinase or thrombin diminished the uptake of 125I-antithrombin III by up to 80%, whereas pretreatment with plasmin, hyaluronidase or FPR thrombin had little effect. Moφhometric analysis of the subendothelium from enzyme-treated and -untreated tissues showed that, whereas plasmin, thrombin and heparitinase each caused a dramatic reduction of the large proteoglycan granules of the extracellular matrix, only exposure to heparitinase and thrombin caused a reduction in the small proteoglycans which populate the basement membrane of smooth muscle cells. Of the subendothelium-bound 125I-antithrombin III, more than 80% was efficiently removed by excess thrombin or by excess heparin. Evidence was obtained for the formation of high molecular weight thrombin-antithrombin III complexes. We conclude that antithrombin III binds largely to proteoheparan sulphate located in the basement membrane of the intimal smooth muscle cells for the purpose of inactivating certain proteases which arise during haemostatic change
ISSN:1018-1172
DOI:10.1159/000158717
出版商:S. Karger AG
年代:1988
数据来源: Karger
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3. |
2nd International Symposium on Resistance Arteries |
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Journal of Vascular Research,
Volume 25,
Issue 1,
1988,
Page 28-52
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PDF (4370KB)
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ISSN:1018-1172
DOI:10.1159/000158718
出版商:S. Karger AG
年代:1988
数据来源: Karger
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