摘要:

Exocrine pancreatic function was evaluated in patients with primary diabetes mellitus by oral administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (pancreatic function diagnostant test, PFD test) and p-aminobenzoic acid (PABA absorption test). In both primary diabetes mellitus and chronic pancreatitis, the mean excretion of PABA in the urine in the PFD test was significantly less than in the controls, and in 19 of 31 (61.3%) patients with primary diabetes mellitus and 11 of 12 (91.7%) patients with chronic pancreatitis there was a low PABA excretion rate. In contrast, the mean excretion of PABA in the urine in the PABA absorption test was significantly less in those with primary diabetes mellitus than in the controls. Therefore, to detect disturbances of pancreatic exocrine function in patients with primary diabetes mellitus, differences in the excretion of PABA in the urine between PFD test and PABA absorption test should be calculated. According to this method, the rate of abnormality was 12.9% in primary diabetes mellitus and 100% in chronic pancreatitis. There was a significant correlation between the excretion of PABA in the urine in the PFD test and results of renal function tests in primary diabetic patients with a normal range of serum creatinine levels. The serum PABA levels in the PFD test remained high in patients with primary diabetes mellitus and decreased in cases of chronic pancreatitis, as compared with the controls.

ISSN:0012-2823    

DOI:10.1159/000198862

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The changes occurring in the ileal wall and in enteroglucagon cells were studied in a rat model of intestinal adaptation, obtained by the transposition of a segment of distal ileum into the mid-duodenum (6 rats, compared with 6 transected controls). After 40 days, the transposed ileal segment, compared to the equivalent segment in the controls, showed striking increase in weight, especially of the epithelium (1,585 ± 127 vs. 305 ± 42 mg, mean ± SEM, p < 0.0005). The calculated weight of enteroglucagon cells in the segment showed a smaller, but significant increase (1.7 ± 0.3 vs. 0.8 ± 0.2 μg, p < 0.05). Plasma enteroglucagon was markedly raised (239 ± 28 vs. 61 ± 7.1 pmol/l, p < 0.0005) and showed a greatly increased meal-stimulated response (1,521 ± 284 vs. 83 ± 43 pmol, p < 0.0005), thus suggesting hyperactivity of enterogluca

ISSN:0012-2823    

DOI:10.1159/000198863

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Antrectomy reduced the levels of circulating gastrin but did not change jejunal morphology. In vitro and in vivo absorption as well as the activity of some brush border enzymes were increased. The observed alterations are discussed on the basis of antrectomy-induced alterations in the release of gastrointestinal hormones, gastric and pancreatic secretion and gastric emptying.

ISSN:0012-2823    

DOI:10.1159/000198864

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In the nonanesthetized rat, the jejunal permeability to four simultaneously administered molecules, mannitol, phenol red, inulin and PVP, was measured by analyzing blood, serum, urine and duodenal fluid for these compounds. Of the molecules which had entered the body, approximately 50% were found in the urine, another 50% in the extracellular space and only about 1 % were excreted into the duodenal juice. The intracellular content of the molecules is not accounted for in these numbers. The rate of permeation decreased with increasing molecular weight of the substances. EDTA (25 mmol/l) and deoxycholate (5 mmol/l) increased the jejunal permeability for these molecules but not for mannitol. The alterations in mucosal cell turnover and morphology induced by hydroxyurea did not change jejunal permeability for mannitol and phenol red at any time. 24 and 48 h following hydroxyurea, jejunal permeability for inulin and PVP was decreased.

ISSN:0012-2823    

DOI:10.1159/000198865

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A system used to record myoelectrical activity from the rectosigmoid colon has been modified so that a continuous recording of electrical resistance is obtained simultaneously. Normal subjects, patients with diverticular disease and patients with the irritable colon syndrome have been studied by this method. There were variations in resistance in the form of waves for 74.7, 88.5 and 89.0% of the time in the three groups. These changes were abolished by intravenous glucagon. The predominant frequency of the waves was 2–4 c/min and often coincided with myoelectrical waves of the same frequency. It is concluded that the resistance changes are produced by local movement in the colonic wall at the electrode site and that this technique may be valuable in studying colonic motilit

ISSN:0012-2823    

DOI:10.1159/000198866

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Common bile duct stones from 59 consecutive patients who underwent cholecystectomy more than 1 year before radiological detection of choledocholithiasis (group I) and from 31 consecutive patients with choledocholithiasis and gallbladder in situ (group II) were subjected to chemical analysis and compared with the composition of gallbladder stones from the same population (two consecutive biopsy and autopsy series, n = 343). In contrast to cholecystolithiasis, inorganic calcium salts were infrequent in choledocholithiasis while calcium bilirubinate and fatty acid calcium salts played an important role in the composition of common bile duct stones. This is of particular importance in terms of litholysis. With respect to stone pathogenesis, clinical and radiological data were analyzed, as was hepatic bile lipid composition. There was no significant difference in the lithogenic index (percent cholesterol saturation) in cholecystectomized and in non-cholecystectomized patients with choledocholithiasis. The most important cause of stone recurrence in the common duct after surgery was incrustation of unabsorbed suture material, which was the case in 30.5% of group-I patients.

ISSN:0012-2823    

DOI:10.1159/000198867

出版商:S. Karger AG    

年代:1983

数据来源: Karger