ISSN:0012-2823    

DOI:10.1159/000187687

出版商:S. Karger AG    

年代:1898

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000187688

出版商:S. Karger AG    

年代:1898

数据来源: Karger

摘要:

124 male Wistar rats weighing 80–120 g were randomized into 2 groups, one receiving ad libitum 20% ethanol, the other water as drinking fluid. Each group has been divided in series of 8 to 12 rats which received 4 different diets combining different ratios of casein and fats. The experiments lasted from 2 to 21 months. Trypsinogen, amylase, lipase, protein and DNA were measured at the end of the experiment. The action of ethanol is closely related to the dietary ratio of proteins and lipids: (1) With a 17–18.5% protein intake and a 10% lipid diet, amylase and chrymotrypsinogen are significantly reduced, but with a 35% fat diet, amylase, trypsinogen and chymotrypsinogen are increased as well as, very probably, the enzyme concentration in the zymogen granules. This increased concentration might explain the toxic action of ethanol in man, facilitating precipitation of protein plugs in the ducts, found in the first stage of chronic alcoholic calcifying pancreatitis. (2) With a 5–6% protein diet, ethanol lowers moderately the pancreaticconcentration of these enzymes. With increased lipid ratios of the diet, the level of thepancreatic enzymes is re

ISSN:0012-2823    

DOI:10.1159/000197092

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000187689

出版商:S. Karger AG    

年代:1898

数据来源: Karger

摘要:

Using the rat intestinal loop technique, it has been demonstrated that in the absence of intrinsic factor, small amounts of 57Co-B12 placed in the loop are either adsorbed onto the mucosa or bound to a macromolecular substance in the lumen to become unabsorbable. Only a large excess of intrinsic factor with respect to B12 binding capacity makes such complexed B12 available for absorption. The mucosa of rat small intestine has a considerable reserve of B12 binding capacity, probably on the surface, and is constantly releasing a non-intrinsic factor B12 binder into the lumen. The surface bound free B12 is eventually shed with mucous flocculi to be expelled. Pronase counteracted this ‘inactivating’ reaction in the loop, and kept small doses of B12 in its free form for a long period of time, effecting an absorption that was slow but almost as large as that obtained with intrinsic factor. Indication was obtained by the analyses of intestinal contents following oral administration of 57C-B12, that this inactivating reaction is normally operative in the small intestine counter to the protection of B12 molecules by intrinsic factor and possibly by pancreatic protea

ISSN:0012-2823    

DOI:10.1159/000197094

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000187690

出版商:S. Karger AG    

年代:1898

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000187691

出版商:S. Karger AG    

年代:1898

数据来源: Karger

摘要:

Serum levels of monoamine oxidase (SMO) have been determined in 16 normal adults, in 76 patients with hepatic diseases and in 44 patients with non-hepatic diseases. Elevated enzyme levels were found in patients with cirrhosis and in those with chronic hepatitis or liver cancer associated with moderate or advanced fibrosis. It was also observed that levels of SMO increased gradually with progression of hepatic fibrosis. The increased enzyme concentration could not be ascribed to hepatocellular necrosis or cholestasis. In non-hepatic diseases, elevated levels of SMO were observed in the patients with acromegaly, hyperthyroidism and prooxidase gressive systemic sclerosis, in which biosynthesis and degradation of collagen were considered to be enhanced by overproduction of hormones or by unknown causes. The determination of SMO concentration is useful as a supplemental diagnostic procedure for organ fibrosis, especially for advanced hepatic fibrosis.

ISSN:0012-2823    

DOI:10.1159/000197095

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197096

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000187692

出版商:S. Karger AG    

年代:1898

数据来源: Karger