摘要:

Urinary copper excretion was found to be increased in patients with cholestasis, hepatitis and cirrhosis, but the penicillamine-induced increment was normal. Wilson’s disease patients had increased copper excretion before and after penicillamine, especially in untreated case

ISSN:0012-2823    

DOI:10.1159/000198559

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Effects of indomethacin on healed or partially healed gastric ulcers in the dog were studied. Gastric ulcers were produced by submucosal injection of 1 ml of 40% acetic acid solution into the bordering area of the fundus and antrum of the stomach. Indomethacin, 20 mg/kg, was given orally once daily for 5 days beginning on the 50th day after ulceration. While erosions or deep ulcers were produced by indomethacin, healed or partially healed acetic acid ulcers were not aggravated. Mechanisms involved in this strong resistance of healed ulcers to the ulcerogenic agent remain to be determined.

ISSN:0012-2823    

DOI:10.1159/000198560

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

20 percutaneous aspirations, guided by ultrasound, were performed without serious complications in 17 patients with cystic pancreatic lesions. Amylase activities of all 10 pseudocysts were increased with a considerably wide range (3,680–775,000 U/l) and the serum amylase level correlated significantly (p < 0.01) with the enzyme activity of cyst content. The enzyme level of 1 true cyst and 2 cystic malignancies were in the normal range of serum amylase; low amylase activity does not rule out a pancreatic origin of a cystic mass lesion. Bacteriological and cytological studies of aspirated samples revealed 2 (of 2) pancreatic abscesses and 2 (of 3) cystic malignancies. Total regression of an acute pancreatic pseudocyst was achieved following repeated percutaneous antegrade evacuation

ISSN:0012-2823    

DOI:10.1159/000198561

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effect of intravenous somatostatin on bombesin-stimulated serum gastrin and gastric acid secretion was studied in 5 healthy subjects. Somatostatin, 100 ng/kg/min, significantly inhibited serum gastrin and gastric acid responses to infusion of bombesin-tetradecapeptide in a dose of 2.5 ng/kg/min. Inhibition of gastrin release could not fully account for the inhibition of gastric acid secretion. Since both bombesin and somatostatin are present in the antrum of man, interrelations between these peptides might be involved in gastrin release from the antrum.

ISSN:0012-2823    

DOI:10.1159/000198562

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In a previous study, we found that pancreatic stones could be dissolved in vitro by a citrate solution. We then decided to look for the possible secretion of citrate into the pancreatic juice, and to find a means of increasing it. Pancreatic juice secretion was collected in Thomas fistula dogs submitted to four protocols: basal conditions, secretin stimulation (0.5 and 2.0 U · kg-1 · h-1), caerulein boluses (25 and 100 ng · kg-1) superimposed on 0.5 U · kg-1 · h-1 secretin and intraduodenal citrate infusion (1.05 mmol kg-1 · h-1). Under basal conditions mean citrate output per 15 min was 0.11 ± 0.02 μmol. During secretin and caerulein stimulation, citrate output paralleled that of protein, and a linear regression was calculated: Ycitrate = -0.013 + 0.019 Xprotein (μmol/mg). Intraduodenal citrate infusion induced a sharp increase in citrate output which reached 11.5 μmol/l5 min, but only 0.12% of the infused citrate amount was secreted into pancreatic juice d

ISSN:0012-2823    

DOI:10.1159/000198563

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Gastric mucosa of the cat generates PGE2 activity at a significantly higher concentration in the antral 59.25 ± 7.42 ng/g) than in the oxyntic (28.06 ± 4.50 ng/ml) gland area. Intravenous (i.v.) infusion of histamine (80 μg/kg/h) or intragastric (i.g.) instillation of 0.1 N HCl (4 mEq/h) for 3 h significantly decreased the generation of PGE2 in antral and fundic mucosa, but did not result in the formation of gastric lesions. Aspirin (ASA) given i.v. or i.g. for 3 h caused a further fall in the generation of PGE2 in the mucosa and when combined with i.v. histamine or i.g. HCl, it caused almost complete disappearance of PGE2 activity and the formation of antral ulcers in all tested cats. Exogenous PGE2 given i.v. in a dose (30 μg/kg/h) reducing histamine-stim-ulated (80 μg/kg/h) acid secretion by about 50%, prevented almost completely the formation of gastric ulcers induced by a combination of ASA plus i.v. histamine or i.g. HCl. This study indicates that the gastric mucosa generates PGE2 which is capable of preventing gastric ulcers induced by ASA combined with histamine or mucosal acidifica

ISSN:0012-2823    

DOI:10.1159/000198564

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Bovine pancreatic polypeptide (PP) was infused intravenously in 5 healthy subjects on two separate occasions with mean doses of 1 and 2 pmol kg-1 min-1, respectively, which achieved plasma levels equal to and twice those observed after a normal mixed breakfast. The gastric emptying rate of a carbohydrate-rich breakfast 20 min after the start of each PP infusion was not significantly different from a control infusion of 0.15 M saline. PP is unlikely to be an important physiological modulator of gastric emptying rate in man.

ISSN:0012-2823    

DOI:10.1159/000198565

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Fasting and postprandial levels of gastrin, insulin, gastric inhibitory polypeptide, pancreatic polypeptide, motilin, enteroglucagon and neurotensin were measured in 42 patients with irritable bowel syndrome (IBS). No overall major abnormalities of secretion of any of these peptides were found, although minor differences from normal of pancreatic polypeptide and neurotensin were observed. It is doubtful whether abnormalities of gut hormone secretion play an important role in the pathophysiology of IBS.

ISSN:0012-2823    

DOI:10.1159/000198566

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000193168

出版商:S. Karger AG    

年代:1915

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000193169

出版商:S. Karger AG    

年代:1915

数据来源: Karger