摘要:

Exocrine pancreatic function has been evaluated in 24 controls and 29 patients with confirmed chronic pancreatitis by continuous infusion (90 min) of synthetic caerulein, 100 ng/kg/h, plus GIH secretin, 1 CU/kg/h. Mean secretory values of the controls were comparable to those obtained by others using maximal doses of secretin and CCK. Unlike the controls, patients suffering from chronic pancreatitis demonstrated a progressive reduction in secretion during infusion. Thus, the comparison of responses for the final 30-min period gave much clearer and more complete discrimination between normal and abnormal pancreatic function than the preceding 30-min period.

ISSN:0012-2823    

DOI:10.1159/000197914

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191551

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

The exocrine pancreatic function was studied in humans by performing a secretin-cholecystokinin test before and after treatment with oxytetracycline or chloramphenicol. In the oxytetracycline-treated patients there was a depression of the amylase and lipase outputs in the duodenal secretion, chymotrypsin decreasing only slightly. Administration of chloramphenicol produced a decrease in the amylase output only. After treatment with the two antibiotics the calcium secretion was reduced. The other parameters measured in the duodenal secretion remained essentially unchanged. The enzyme dissociation observed in the present studies is considered to reflect the onset of pancreatic dysfunction due to antibiotic administration. As in the previous animal experiments, the suggested explanation for the changes in enzyme secretion is an inhibition of protein synthesis in the exocrine pancreas due to oxytetracycline and chloramphenicol.

ISSN:0012-2823    

DOI:10.1159/000197915

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191552

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

The uninvolved gastric mucosa of gastric ulcer and gastric carcinoma patients has been compared in in vitro studies as regards their capacity to bind demethylchlortetracycline (DMCT). Dialysis experiments demonstrated excessive binding of DMCT in gastric cancer. Several electrophoretic fractions were observed that bound DMCT; it was demonstrated that these fractions differed in the uninvolved mucosa of gastric ulcer and gastric cancer patients.

ISSN:0012-2823    

DOI:10.1159/000197916

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000191553

出版商:S. Karger AG    

年代:1908

数据来源: Karger

摘要:

Absorption of an oral dose of 300 mg of Cimetidine was studied after an overnight fast in six healthy male volunteers on three separate occasions, 20 min before, during, and 2 h after a standard breakfast. Compared to the doses taken before and after the meal, the dose taken with the meal showed a significant delay in the time taken to reach therapeutic blood concentrations of the drug with no reduction in the period of time during which this concentration was maintained. We, therefore, suggest that the drug should be taken with a meal to achieve optimal acid inhibition in the interdigestive period.

ISSN:0012-2823    

DOI:10.1159/000197917

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Dose-response curves for the effect of continuous infusion of histamine on gastric acid secretion were obtained in 10 patients with iron deficiency anemia due to hookworm infection. Each patient was studied with 4 doses (40, 60, 80 and 100 μg/kg/h) of histamine acid phosphate administered for 3 h, on separate days, in random fashion. The acid output increased with the dose of histamine, the maximal acid output was reached in all patients at the dose of 100 μg/kg/h. The dose of histamine when calculated according to body weight correlated well with the maximal acid output; the absolute dose of histamine had no correlation with the maximal acid response. The dose-response curve of stimulated acid output in anemia patients was much flatter than in control patient

ISSN:0012-2823    

DOI:10.1159/000197918

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Fundic mucosal extracts of the cat were examined by chromatography using DEAE-cellulose at pH 5.3. The peaks of proteolytic activity located by this method were shown to be heterogeneous on electrophoresis. By electrophoresis of individual homogenous chromatographic fractions 9 separate zones of proteolytic activity were detected. One zone did not migrate from the origin and is possibly a non-pepsinogen gastric protease. Simultaneous electrophoresis of pepsinogens and pepsins indicated that each pepsinogen gave rise to one pepsin. One zymogen gives rise to a pepsin active with the synthetic substrate acetyl-L-phenylalanyl-L-diiodotyrosine (APDT).

ISSN:0012-2823    

DOI:10.1159/000197919

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In dogs with gastric fistulas and denervated pouches from the oxyntic area, the acid secretory responses to a meal and to graded doses of histamine and pentagastrin were measured before and after resection of the upper half of the small bowel. Intestinal resection caused a small but significant increase in submaximal and maximal responses from the pouch to histamine and pentagastrin without modification of the ED50. This effect was not observed in the innervated stomach. The response from the pouch to feeding was markedly increased and prolonged. These data indicate that both an increase in stimulation and an increase of the response to this stimulation are responsible for the increased acid secretion observed in the pouch when resected dogs were fed. These effects could be explained by the withdrawal of inhibitors of intestinal origin.

ISSN:0012-2823    

DOI:10.1159/000197920

出版商:S. Karger AG    

年代:1976

数据来源: Karger