摘要:

Basal and stimulated gastric hydrochloric acid secretion was studied in 22 chronic fistula ferrets during estrus and anestrus. Maximal doses of histamine, pentagastrin, and insulin, and basal secretion were assessed. Basal secretion was unaltered by estrus. During estrus acid output, concentration, and volume output after i. p. histamine were unaltered but peak concentration and volume were slightly increased after s.c. histamine, suggesting that a hepatic factor, related to route of administration, may have altered the histamine effect. Pentagastrin and insulin-induced stimulation was slightly increased during estrus in acid concentration, but output and volume were unchanged. Histamine and pentagastrin response kinetics generally followed the pattern, log Y = a + b (log X) + c (log X)2. Insulin responses were delayed, following the pattern, Y = a + bX + cX2. This study suggests that natural hormonal changes may slightly alter the gastric secretory responses to test agents in the ferret.

ISSN:0012-2823    

DOI:10.1159/000197186

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

The 30-min peak acid output (PAO30) to pentagastrin and insulin hypoglycemia has been compared in male and female ulcer patients. In male duodenal ulcer, prepyloric gastric ulcer and corporal gastric ulcer patients the PAO30 to pentagastrin exceeded that to insulin; in female duodenal ulcer patients the PAO30 to pentagastrin tended to be higher than to insulin but the difference was not significant. The PAO30 to both pentagastrin and insulin was higher in male than in female duodenal ulcer patients but the ratio of PAO30 for insulin and pentagastrin did not differ significantly which suggests that the sex difference in the responses is similar for insulin and pentagastrin. The ratio tended to be lower in the male corporal gastric ulcer than in the male duodenal ulcer patients which might indicate that insulin hypoglycemia is relatively less effective than pentagastrin in stimulating acid secretion in corporal gastric ulcer than in duodenal ulcer patients.

ISSN:0012-2823    

DOI:10.1159/000197187

出版商:S. Karger AG    

年代:1972

数据来源: Karger

摘要:

A patient associated with generalized gastrointestinal polyposis, pigmentation of the skin, alopecia, loss or atrophy of finger- and toenails, cataract and hypoproteinemia is reported. This case appears to be the same as the Cronkhite-Canada syndrome, derived from the names of those who first described it.

ISSN:0012-2823    

DOI:10.1159/000197188

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197189

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197190

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197191

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197192

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197193

出版商:S. Karger AG    

年代:1972

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197194

出版商:S. Karger AG    

年代:1972

数据来源: Karger