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1. |
Extensive Small Bowel Resection in the Rat: Lack of Effect on Serum Proteins |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 1-7
Ernest Urban,
Phillip M. Ricks,
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摘要:
Rats were subjected to serial venesections 3 days prior to and then sequentially for 4 weeks after surgical removal of either the proximal or distal half of the small bowel. Total serum protein concentration and protein electrophoretic patterns were determined on these sera. Both sham-operated and unoperated animals served as controls. The data showed differences in serum proteins in the first week after operation between the three groups of operated rats and the unoperated controls. However, there were no significant differences in serum proteins between the sham-operated and the two types of resected animals. This indicates that the combined effects of laparotomy, anesthesia, pre- and postoperative fasting outweighed any additional early effects of loss of 50% small bowel on serum proteins. The study also demonstrates the necessity of having both unoperated and sham-operated control groups in designing experiments involving surgical extirpation of intestine.
ISSN:0012-2823
DOI:10.1159/000198408
出版商:S. Karger AG
年代:1980
数据来源: Karger
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2. |
Effect of Chenodeoxycholic Acid on Liver Structure and Function in Man: a Stereological and Biochemical Study |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 8-21
M.M. Koch,
M.P. Giampieri,
I. Lorenzini,
A.M. Jezequel,
F. Orlandi,
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摘要:
Chenodeoxycholic acid (CDCA) is an effective treatment for dissolving gallstones but experimental studies have suggested that it might be hepatotoxic. The present study is concerned with a group of patients undergoing medical therapy for gallstones for periods of 30 days up to 14 months with CDCA (15 mg/kg/day). Routine functional tests, determination of some liver microsomal enzymes and stereological studies of the liver tissue have been performed and the data have been compared with those obtained before treatment. No significant changes were observed in the functional tests throughout the study. Also the microsomal mixed function oxidase system seemed unaffected by CDCA therapy. The histological features of the liver biopsies were not appreciably different from those observed prior to treatment. Although there were large interindividual variations, the volume density of parenchymal steatosis and of the lipocytes remained comparable in the same individual. The ultrastructural features noted in untreated subjects such as curled mitochondrial cristae, slight intracellular bile retention, increased surface density of the rough endoplasmic reticulum were still evident after 14 months of treatment. No additional changes were noted. These results show that no evidence of hepatotoxicity seems to develop in man under therapy with CDCA at the dose considered. But the structural abnormalities observed before treatment appear to persist even in subjects under long-term therapy.
ISSN:0012-2823
DOI:10.1159/000198409
出版商:S. Karger AG
年代:1980
数据来源: Karger
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3. |
Kuhmilch und vegetabile Milch und ihre Unterschiede in der Magenverdauung besonders mit Rücksicht auf das Problem der Kuhmilch-Intoleranz |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 13-48
A. Fischer,
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ISSN:0012-2823
DOI:10.1159/000193071
出版商:S. Karger AG
年代:1914
数据来源: Karger
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4. |
Haemoperfusion through Activated Charcoal in Dogs with Fulminant Liver Failure |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 22-30
J. Horák,
J. Horký,
M. Rábl,
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摘要:
The effects of 8-hour haemoperfusion through an activated charcoal column on fulminant hepatic failure were assessed in 10 dogs. The survival in the perfused animals was significantly prolonged and the onset of liver encephalopathy was markedly delayed compared to the controls. Significant decrease in plasma bilirubin and total plasma phenols was found in the perfused group. No other laboratory changes due to haemoperfusion were found. The charcoal column retained its adsorptive capability throughout the experiment as judged from phenol clearance values. In spite of current scepticism regarding its clinical use, further trials with haemoperfusion in acute liver failure seem to be warranted.
ISSN:0012-2823
DOI:10.1159/000198410
出版商:S. Karger AG
年代:1980
数据来源: Karger
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5. |
Incidence and Significance of Juxtapapillary Diverticula at Endoscopic Retrograde Cholangiopancreatography |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 31-35
A.P. Kirk,
J.A. Summerfield,
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摘要:
In a retrospective study of 755 patients undergoing endoscopic retrograde cholangiopancreatography from 1973 to 1977 at the Royal Free Hospital, 38 (5%) had a juxtapapillary diverticulum. This resulted in a significantly higher failure rate of cannulation of the ampulla of Vater (40 vs. 20% in the remainder of the group; p < 0.02). The presence of a juxtapapillary diverticulum was also significantly associated with an increase of cholelithiasis (48 vs. 24%; p < 0.01), and with jaundice or cholangitis developing after cholecystectomy (27 vs. 8%; p < 0.001). There was no evidence that the diverticula were the cause of biliary or pancreatic obstruction.
ISSN:0012-2823
DOI:10.1159/000198411
出版商:S. Karger AG
年代:1980
数据来源: Karger
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6. |
A Simple Non-Radioactive Method for the Simultaneous Quantitative Determination of Stomach Emptying and Intestinal Propulsion in the Intact Conscious Rat |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 36-49
L.E. Borella,
W. Lippmann,
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摘要:
A simple non-radioactive method for the simultaneous assessment of stomach emptying and intestinal propulsion in intact fasted conscious rats was developed employing Amberlite pellets. The Amberlite pellets were administered by gastric gavage and the rats were killed 20 or 120 min later. The number and percent of the pellets in the stomach and intestines and the distance travelled by each pellet in the small intestine were determined. The distance travelled by the leading pellet in the small intestine was employed as a parameter to determine effects on intestinal propulsion independent of the stomach emptying activity. Chlorisondamine (s.c), atropine (s.c), pentobarbital (i.p.) and sesame seed oil (p.o.) inhibited both stomach emtying and intestinal propulsion in a dose-related manner. All these agents also caused a dose-related displacement of the pellets in the small intestine which resulted in a more cephalad-oriented distribution of the pellets. Propantheline (s.c.) exerted a dose-related inhibition on the stomach emptying but not on intestinal propulsion. Carbachol (s.c.) increased both the rate of stomach emptying and that of propulsion in the small intestine.
ISSN:0012-2823
DOI:10.1159/000198412
出版商:S. Karger AG
年代:1980
数据来源: Karger
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7. |
Über die Boassche Chlorophyllprobe zur Bestimmung der Magenmotilität |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 49-65
Heinrich Kemmerling,
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ISSN:0012-2823
DOI:10.1159/000193072
出版商:S. Karger AG
年代:1914
数据来源: Karger
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8. |
Notion of Time Factor in Calcium Absorption |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 50-55
Y. Dupuis,
G. Crouzoulon,
P. Fournier,
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摘要:
The unidirectional influx of Ca (measured by in vitro methods) was similar along the intestine of the adult rat, from Treitz ligament to ileo-caecal valve. In in vivo ligated loop experiments, the rate of Ca absorption was similar during 30 min irrespective of site, sex and the presence of L-xylose in the Ca solution. On the contrary, these factors modified the quantity of Ca absorbed. After 30 min, absorption stopped in the male ileum whereas it continued (1) in the male jejunum; (2) in the ileum of the female, and (3) in the male ileum in the presence of xylose (absorption being proportional to xylose concentration). Thus, in the adult rat, the duration rather than the rate is the decisive factor in Ca uptake.
ISSN:0012-2823
DOI:10.1159/000198413
出版商:S. Karger AG
年代:1980
数据来源: Karger
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9. |
Interest of a Combined Antisecretory Treatment, Cimetidine and Pirenzepin, in the Management of Severe Forms of Zollinger-Ellison Syndrome |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 56-61
M. Mignon,
T. Vallot,
J.P. Galmiche,
J.L. Dupas,
S. Bonfils,
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摘要:
Inhibition of gastric acid secretion by the combined use of cimetidine and pirenzepin has been studied in 5 cases of Zollinger-Ellison syndrome. In 4 acute cases i.v. cimetidine and i.m. pirenzepin were administered together as a treatment and were successful in 3 out of the 4 cases as judged by the disappearance of clinical symptoms and healing of the gastroduodenal and jejunal mucosal ulcerations. Secretory measurements indicated that addition of pirenzepin to cimetidine resulted in larger and more prolonged inhibition of acid secretion in these patients. The continuous record of intragastric pH in the 5th patient, over 24-hour periods, confirmed the above findings. Despite the use of large doses of pirenzepin, no significant side effects were noticed.
ISSN:0012-2823
DOI:10.1159/000198414
出版商:S. Karger AG
年代:1980
数据来源: Karger
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10. |
Human Colonic Adenylate Cyclase |
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Digestion,
Volume 20,
Issue 1,
1914,
Page 62-67
Bernd Simon,
Horst Kather,
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摘要:
The effects of meclofenamic acid on basal and hormone-stimulated adenylate cyclase in human colonic mucosa were tested. It is shown that meclofenamic acid is a relatively specific inhibitor of the stimulatory action of prostaglandins on the level of mucosal adenylate cyclase. This compound did not inhibit significantly the effects of vasoactive intestinal peptide (VIP) on the human enzyme system. VIP18-28 did not act as a partial agonist and did not inhibit the response to the intact VIP. Our studies suggest the existence of distinct receptor sites for both secretagogues (VIP and prostaglandins) in human colonic mucosa.
ISSN:0012-2823
DOI:10.1159/000198415
出版商:S. Karger AG
年代:1980
数据来源: Karger
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