摘要:

37 patients were studied with calcium infusions. Of these, 20 had previously undergone truncal vagotomy and pyloroplasty for duodenal ulcer disease, and 17 were unoperated patients with duodenal ulcer disease. Calcium was given intravenously either at a dose of 5 mg/kg/h for 3 h, or 4 mg/kg/h for 4 h. Gastric juice was collected by continuous suction. Results showed the 3-hour infusion raised calcium more than the 4-hour infusion. Top serum calcium achieved, however, did not correlate with calcium-stimulated gastric acid output, either with or without vagotomy. Stimulated gastric acid secretion was markedly less with vagotomy than without. It is suggested that the level of gastric acid stimulated by infusions might discriminate complete, from incomplete, vagotomies better than insulin, and that the 4-hour infusion is safer.

ISSN:0012-2823    

DOI:10.1159/000197961

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

11 patients with jaundice of Dubin-Johnson type were treated for 2 weeks with phenobarbital. Serum bilirubin diminished and hepatic clearance of sulfobromophthalein was variably enhanced; other measures of hepatic function were not significantly changed during therapy.

ISSN:0012-2823    

DOI:10.1159/000197962

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In 504 Jewish patients with ulcerative colitis the following risk factors were evaluated: sex, age at onset of disease, community group, extent of disease, and duration of disease. The disease was more severe in females. Severe attacks, weight loss, iron deficiency, liver disease and arthritis were significantly more frequent in females than in males. Mortality was higher in patients who contracted the disease above age 50. The disease appeared to be more severe in patients of Ashkenazi origin as compared to Orientals. The difference failed to reach statistical significance except for mortality. We confirmed the well-known adverse effect of extensive colonic involvement. Severe attacks, a severe course of the disease and extensive colonic involvement are more frequent with increasing duration of the disease.

ISSN:0012-2823    

DOI:10.1159/000197963

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A sensitive method for measuring haemoglobin in gastric contents using the rate of change of optical density of a mixture of orthotolidine and hydrogen peroxide in the presence of haemoglobin, is described. The method can measure the blood normally lost in 10 min from the gastric mucosa.

ISSN:0012-2823    

DOI:10.1159/000197964

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The action of cholecystokinin (CCK) and caerulein upon the rabbit sphincter of Oddi was investigated by eiectromyography, manometry and measuring of the flow. Intravenous injection of CCK resulted in a marked rise of the sphincter activity with a maximum at the 1st min and return to the basal level at the 10th min. Injection of increasing doses of hormone showed that the effect was proportional to the logarithm of the dose. The same results were obtained with caerulein. Parallely, CCK provoked a rise of the biliary pressure also proportional to the logarithm of the dose and a reduction to the biliary flow. The discrepancies between these results and some other experiments are discussed. It is concluded that, in the rabbit, CCK increases the activity of the sphincter of Oddi.

ISSN:0012-2823    

DOI:10.1159/000197965

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Ulcerative colitis and Crohn’s disease are complex, problematic diseases of unknown etiology in man, and appropriate experimental models would be useful in elucidating their pathogenesis and treatment. Although there have been numerous attempts to produce inflammatory ulcerative colonic disease in laboratory animals resembling those human disease forms, none has been entirely successful. Investigators have conducted experiments involving almost every etiological factor suggested for initiation of these diseases. The methods reviewed in this paper include production of experimental colitis by vascular impairment, and immunological methods such as bacterial infection, allergic reactions, direct and indirect hypersensitivity reactions, as well as autoimmune mechanisms. The results of carrageenan-induced colitis, irradiation, dietary, and drug-induced techniques are also discussed and the frequency and nature of spontaneous colonic lesions in animals is summarized.

ISSN:0012-2823    

DOI:10.1159/000197966

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000197967

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000318037

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000318040

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000318039

出版商:S. Karger AG    

年代:1976

数据来源: Karger