ISSN:0012-2823    

DOI:10.1159/000198326

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Serum lipoproteins and fecal fat were determined in 37 patients with Crohn’s disease, who had been submitted to ileal resections. All patients were studied in a quiescent phase of the disease, on average 5 years after the last operation, and all except one had a daily intake of dietary fat lower than 70 g. A significant positive correlation existed between the length of the resected intestine and the fecal fat excretion. Total triglyceride (TG) concentrations were similar in patients and a group of carefully matched controls. In spite of a mean resection length of 8.6 dm of ileum, hypertriglyceridaemia (type IV) was found in 7 patients. The reduced cholesterol concentration in the patients was due to a marked reduction of the low-density lipoprotein (LDL) cholesterol concentration. The LDL cholesterol concentration was negatively correlated to the length of the resected intestine. The average high-density lipoprotein (HDL) concentration was similar in healthy controls and patients, but in the latter the HDL cholesterol concentrations were lower the more extensive the ileal resections. The very-low-density lipoprotein cholesterol concentration showed no significant abnormality. These data support the concept that in patients with ileal resections other factors may compensate for the limited dietary fat supply to maintain a normal TG concentration in plasma. The low total cholesterol concentration is due to a reduction in the LDL fraction only, and reflects probably that all cholesterol used for enhanced bile acid synthesis is provided by this fraction. The negative correlation between the extent of the resection and the HDL cholesterol concentration supports indirectly the hypothesis that HDL particles may be secreted not only from the liver but also from the small intestin

ISSN:0012-2823    

DOI:10.1159/000198327

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A study of the motor activity of the gastroduodenal (GD) junction has been carried out on 8 subjects by using an original probe provided with a suction cup, that allows not only a duodenogastric (DG) pull-through, but also a prolonged recording of the pyloric, antral and duodenal motor activity, in basal condition and after intraduodenal instillation of HCl 0.1 N and intravenous infusion of cerulein. The position of the probe was controlled with fluoroscopy and transmural potential difference. The DG pull-through did not show a zone of high pressure at the GD junction, but the prolonged study showed, during HCl and cerulein administrations, a significant increase of the pyloric tonus.

ISSN:0012-2823    

DOI:10.1159/000198328

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The purpose of the present study was to determine in the rat whether parenteral aspirin, like topical aspirin, injures the gastric mucosa by diffusely disrupting the gastric mucosal barrier to hydrogen ion back-diffusion. Back-diffusion studies, including ion fluxes and lumenal potential difference, were performed in control situations and either 0.5 or 4 h after the intraperitoneal administration of sodium acetylsalicylate. Gastric mucosal lesions were scored. After 0.5 h, lesions developed but the barrier was intact. However, after 4 h, lesion formation was more severe and changes characteristic of diffuse barrier disruption, fall in potential difference and increased loss of hydrogen ion occurred. Since lesions occurred before evidence of diffuse barrier disruption could be detected, we conclude that in the present model diffuse barrier disruption is a consequence rather than a cause of lesions.

ISSN:0012-2823    

DOI:10.1159/000198329

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The effects of an 8-hour infusion of somatostatin, saline, gastrin or a mixture of gastrin + somatostatin on DNA synthesis and mitotic activity of gastrointestinal progenitor cells were explored in conscious rats, using in vivo labeling with 3H-thymidine and radioautography. Infusion of somatostatin (day or night) was shown to transiently reduce nuclear uptake of 3H-thymidine and cell division in both fundic and antral progenitor cells. Cell DNA synthesis in the gastrin + somatostatin-stimulated stomach was lower than in the gastrin-stimulated stomach. In the intestine, nocturnal infusion of somatostatin decreased DNA synthesis whereas diurnal infusion decreased cell division but no effect was observed on gastrin stimulation. Evidently, somatostatin may inhibit, perhaps indirectly, the cell proliferation in digestive mucosae and antagonize the trophic activity of gastrin but only in fundic and antral mucosae.

ISSN:0012-2823    

DOI:10.1159/000198330

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A multicenter study on the etiology and diet of patients with pancreatic diseases has been realized with the collaboration of 36 centers in 19 countries having widely different climatic and racial conditions. 2,478 cases were studied: acute pancreatitis (AP), 222 males, 208 females; calcified chronic pancreatitis (CCP), 801 males, 134 females; non-calcified chronic pancreatitis (NCCP), 525 males, 155 females; pancreatic cancer (PK), 69 males, 14 females; controls, 281 males, 62 females. The analysis of mutual information and the factorial analysis of correspondences have been used. With regard to chronic pancreatitis, the 19 countries could be classified into 4 classes presenting relative similarities. (A) Southern Europe: The diet is rich in carbohydrates, protein and lipids, alcohol intake is primarily in the form of wine and the pathology is dominated by CCP. There are much fewer women than men with chronic pancreatitis. Northern Europe, to which may be added Argentina and Chile, is characterized by a protein-and lipid-rich diet, a beer-based alcohol consumption and a distinct prevalence of AP and NCCP. The prevalence of males with chronic pancreatitis is less marked than in southern Europe. Japan has a lipid-poor diet and a low frequency of CCP and NCCP. (D) A fourth group is mostly composed of tropical countries with mixed races. It may be divided into 2 subclasses: (a) India is the most characteristic country of the first type with low fat, low protein diet, no alcoholism, high frequency of CCP (at an early age); (b) Brasil and South Africa are representative of the second subclass with very high alcohol intake in the form of spirits and a high frequency of CCP.

ISSN:0012-2823    

DOI:10.1159/000198331

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0012-2823    

DOI:10.1159/000192961

出版商:S. Karger AG    

年代:1913

数据来源: Karger

摘要:

Serum bile acids were determined in 13 cirrhotic patients with portacaval shunt and in 15 with mesocaval shunt. 20 nonshunted cirrhotics were used as controls. Serum bile acid levels were higher in portacaval (26.7 ± 14.3 μg/ml) than in mesocaval shunt patients (16.9 ± 8.1 μg/ml) and controls (14.1 ± 11.5 μg/ml). The cholic/chenodeoxycholic ratio was lower after portacaval shunt than after mesocaval shunt (0.36 ± 0.15 and 0.63 ± 0.26, respectively). It is hypothesized that these findings may be consistent with a larger hepatic blood flow present in mesocaval shunted patients and with chenodeoxycholic absorption in the upper small in

ISSN:0012-2823    

DOI:10.1159/000198332

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Intracellular immunofluorescence staining was used to identify lymphoid cells from human gastric mucosa. Staining of serial sections for each of the five classes of immunoglobulin-containing cells revealed the presence of all classes. Their relative frequencies in the antral mucosae of 30 patients with bile reflux gastritis were 51% IgA, 16% IgM, 18.5% IgG, 2.5% IgD and 12% IgE. The mucosae of 15 control subjects showed 75% IgA, 8% IgM, 15% IgG, 1%IgD and 1% IgE and the mucosae of 30 patients with inflammatory gastritis without bile reflux revealed 67% IgA, 6.5% IgM, 22.5% IgG, 1.5% IgD and 2.5% IgE. These features suggest that allergy participates in the physiopathology of bile reflux gastritis.

ISSN:0012-2823    

DOI:10.1159/000198333

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

2 cases of pancreatic disease in patients with malabsorption following small bowel radiation injury are reported. It is suggested that the pancreatic disease present in these patients occurred as a result of previous radiotherapy.

ISSN:0012-2823    

DOI:10.1159/000198334

出版商:S. Karger AG    

年代:1979

数据来源: Karger