摘要:

ABSTRACT—The etiology of idiopathic portal hypertension (IPH) is not known. To obtain clues to the pathogenesis, an attempt was made to produce a hepatic lesion similar to that in IPH by repeated injections of aggregated killed non‐pathogenicE. colidirectly into the portal vein. In the treated dogs, histology of the liver showed dense fibrosis in the portal tract and an aberrant vasculature around the portal area after 1 month. Portal pressure was elevated and middle‐to‐small‐sized portal branches were decreased in number as studied by portography. These changes closely mimic those seen in human IPH. The possibility is discussed that chronic entrance of an antigen such as bacteria from the intestine to the portal venous system plays an etiologic ro

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00959.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—A histopathologic follow‐up study was conducted in 207 consecutive patients to examine the prognostic significance of bridging hepatic necrosis (BHN) in chronic type B hepatitis. One hundred and eight patients showed BHN and the other 99 intralobular spotty necrosis (SN) on initial biopsy. A higher proportion of patients with BHN healed (45.4% vs 26.4%) or developed cirrhosis (18.3% vs 3%) than the patients with SN. In contrast, intralobular inflammation persisted or recurred more frequently in the SN than in the BHN group (40.4% vs 5.6%). These figures were statistically significant (P<0.001). Alternatively, 87% of the patients who developed cirrhosis had had BHN as their initial histologic presentations. The estimated relative risk of cirrhotic progression for the BHN group compared to the SN group was 4:1. We conclude that BHN is a paradoxical prognostic factor, either for healing, or cirrhotic progress

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00960.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—Inflammatory lesions in the liver simulating tumor formation are rare. Eleven cases have so far been reported in the literature, most of them in recent years. We present an additional case of an “inflammatory pseudotumor” in a 17‐year‐old male. The inflammatory pseudotumor should be kept in mind in the differential diagnosis of hepatic space‐occupy

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00961.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—Three patients showing all the symptoms of idiopathic thrombocytopenic purpura underwent a splenectomy. A wedge liver biopsy revealed hepatic fibrosis around central veins and an increased perisinusoidal network on Sirius red staining. Fibrosis was moderate or mild. Liver histology was otherwise normal, as were liver function tests. Hepatic fibrosis could not be attributed to any known causes. Electron microscopy showed numerous Kupffer cells with intense phagocytic activity, and perisinusoidal cells with some of the characteristics of fibro/myofibroblasts. The mechanisms of fibrosis remain unknown but could be attributed, by analogy to agnogenic myeloid metaplasia, to the massive destruction of platelets liberating PDGF and to increased activation of macrophage

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00962.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—The liver is a steroid‐responsive organ and contains high levels of androgen receptors (AR). The present study investigated cytosolic AR concentrations in diseased human liver obtained by needle biopsy. Insufficient tissue was available for full Scatchard analysis. Previous studies have shown the binding affinity of the liver AR to be sufficiently constant to allow the use of a single saturating dose analysis, using3Hmibolerone as the active ligand, for the estimation of binding sites. Thirteen samples were studied and compared to normal liver. AR was identified in all samples and the level negatively correlated to the degree of liver damage. A role for AR in hepatocellular carcinoma has been postulated and anti‐androgens used in treatment. This study shows AR can be measured in needle‐biopsy specimens and, if hepatocellular carcinoma is proven to be hormone sensitive, then this technique may help in the assessment of such

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00963.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—Electron microscopic features of intrahepatic bile ducts of experimental mouse graft‐versus‐host disease (GVHD) across minor histocompatibility barriers were studied for 14 months after transplantation. In GVHD mice, the bile duct epithelial layer was consistently infiltrated by lymphoid cells and often accompanied by polymorphonuclear leukocytes, monocytes and rarely by plasma cells. The epithelial cells in close contact with and in the vicinity of these infiltrated cells showed a variety of degenerative changes, including darkness of the cytoplasm and the nucleus with shrunken, irregular contours, increase in the amount of endoplasmic reticulum and number of mitochondria, and formation of intracytoplasmic vesicles and diverticula, cytoplasmic blebs, and apoptopic bodies. Lymphocytes were in close contact with epithelial cells through a number of point‐contacts and located in the lateral intercellular spaces and/or between the basement membranes and the epithelial cells. The localization of infiltrating lymphocytes beneath the epithelial cells with conspicuous detachment from the basement membranes strongly suggested a link with subsequent epithelial cell injury and death. The lymphoid cells had irregular cytoplasmic projections which occasionally extended into spaces created by retractions of the epithelial cell membranes, reflecting an activation of the lymphocytes. These findings support the notion that the bile duct lesions in GVHD across minor histocompatibility barriers are mediated by specifically sensitized lymphocytes against epithelial cell membrane antigens. From our previous finding that a large majority of the infiltrating lymphocytes had a phenotype of helper/inducer T cells, a putative role of these lymphocytes in the induction of the bile duct lesions is di

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00964.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—The clinical, morphological and evolutive features of 60 patients with chronic hepatitis, presumably caused by non‐A, non‐B virus infection, have been retrospectively analyzed. In all the cases the disease began as an acute episode of viral hepatitis that was followed by persistently abnormal liver function tests. No patient had evidence of current or past hepatitis B virus infection and other known causes of chronic liver disease were excluded. Thirty patients had received blood transfusions in the recent past, five were drug addicts and the source of the infection was not identified in the remaining 25, in whom the disease was considered to be sporadic. Clinical or biochemical differences between patients with post‐transfusional and sporadic non‐A, non‐B chronic hepatitis were not observed, but liver histology showed a higher proportion of patients with chronic persistent hepatitis in the sporadic (72%) than in the transfusional group (53%). On follow‐up, sustained normalization of liver function tests was observed in 46% of the cases with sporadic hepatitis but only in 13% of the cases with post‐transfusion hepatitis. These observations suggest that non‐A, non‐B chronic hepatitis is more severe in patients with transfusion‐related infection t

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00965.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—Ito cells (FSC) have been thought to be collagen‐producing cells with regard to hepatic fibrosis. We have found that desmin, a structural protein of muscular intermediate filaments, is found in the cytoplasm of FSC, even in negative vitamin A‐autofluorescence FSC, by using immunocytochemical techniques. In the present study, numbers of FSC produced by the administration of heterogeneic serum or carbon tetrachloride were detected in fibrous and non‐fibrous areas of hepatic lobules by using a morphometrical analyser. After 8 weeks of intraperitoneal injections of heterogeneic serum into rats, FSC in fibrous septa increased in number and the increase continued to 12 weeks – although the numbers of FSC in non‐fibrous areas and in controls given homologous serum did not change during the experiment. In the case of rats administered CCl4once, FSC in fibrous areas increased in numbers after 48 h through 72 h, although the number of FSC in non‐fibrous areas and in controls did not change. The results, with an apparent increase in numbers of FSC in fibrous areas and no change in non‐fibrous areas, showed the possibility of hyperplasia due to cell division of FSC in the new fib

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00966.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—In a retrospective study, we review here the clinical presentation of patients with the biphasic form of hepatitis A, a variant of viral hepatitis characterised by an increase in ALAT levels after an initial recovery in clinical condition and laboratory tests. Twenty‐one patients were diagnosed as having a biphasic form; they represent about 10% of a selected population of hepatitis A cases. Six patients were asymptomatic. Eleven patients were jaundiced, nine of them showing a “cholestatic” pattern. The second phase of the disease had a more protracted course and displayed higher ALAT levels than the first phase. The total duration of the disease was 120±28 (mean±SD) days, and its course w

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00967.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

ABSTRACT—It has not yet been established whether serum proline and blood lactate levels are increased in alcoholic liver disease. We measured serum proline and blood lactate in controls and in patients with different stages of alcoholic liver disease in the absence of hepatic failure. Samplings were done in both abstinent and drinking alcoholics. Compared to controls, there was a striking increase in serum proline levels in 52 abstinent alcoholics with little or no hepatic fibrosis by histological assessment (0.10 ± 0.01 vs. 0.155 ± 0.008; p<0.005). Blood lactate levels were within the normal range and did not correlate with serum proline levels. On the other hand, serum proline and blood lactate levels were independent of hepatic necrosis and inflammation scores. In addition, in 10 patients with blood alcohol concentrations between 0.3 mg/ml and 7.8 mg/ml, serum lactate and proline were significantly elevated (2.42 ± 0.29 mg/ml and 0.275 ± 0.0026 mg/ml, respectively; p<0.005). These results show that there is an association between serum proline levels and the abstinence period in alcoholic patients. They further suggest that in alcoholic patients neither serum proline nor blood lactate concentrations are reliable markers for liver histological activity (necrosis and inflammation) or fib

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1988.tb00968.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY