摘要:

ABSTRACT—We have defined some membrane antigens of the cultured hepatocellular carcinoma cell line PLC/PRF/5, which contains the integrated genome of hepatitis B virus. Using fluoresceinated antibodies, we identified HLA Class 1 glycoprotein and HB surface antigen on the membrane. Only in a minority of cells was physical association of these antigens demonstrated by co‐capping. The presence of a “division” antigen was indicated by reactivity of the cells with the murine monoclonal antibo

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00900.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—The incidence of primary liver cancer (PLC) was assessed in 652 patients (429 male, 223 female) with liver cirrhosis. By the end of the study 416 (64%) of all patients had died. The autopsy rate was 65%. PLC developed in 73 patients. Histologically, 67 cases were classified as hepatocellular (HCC), one as mixed hepatocellular‐cholangiocellular and five as cholangiocellular carcinoma. In 30 cases, HCC was confirmed within a year of diagnosis of cirrhosis, and in the remaining 37 cases HCC developed 2–13 years later. At autopsy, the frequency of HCC was almost twice as high in males (27%) as in females (15%) (p<0.025). This difference occurred in alcoholic and posthepatitic cirrhosis but not in cryptogenetic cirrhosis. HBsAg was detected in 19.0% of male and 9.2% of female patients (p<0.01). Comparison of patients with and without HCC revealed no significant differences in the prevalence of HBsAg. These data indicate that HCC is common in Austrian patients with cirrhosis, representing 60% of all malignant tumors in this group. In view of the high HBsAg carrier rate and the prevalence of chronic alcoholism in patients with cirrhosis, it is suggested that the two factors together lead to an increased risk of cirrhosis followed by an increased incidence o

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00901.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—The authors present the clinical and histological findings in a series of 42 liver biopsies from 39 chronic alcoholics treated with cyanamide as aversion therapy. All biopsies displayed characteristic cytoplasmic inclusions in the liver‐cells. Fibrosis and disruption of the parenchymal‐connective tissue interface were observed in all cases. According to the severity and extension of fibrosis, three stages could be depicted:Stage I.Periportal activity cholangiolar type (ACT), which is defined by cholangiolar proliferation, fibroblastic activation and inflammatory infiltrate, which together cause a blurred appearance of the parenchymal‐connective tissue junction. It is the elementary lesion and was observed alone in 26 biopsies.Stage II.Portal‐to‐portal linkage. It was observed in 10 biopsies, all of which also showed periportal ACT. Three of these came from patients with two biopsies in which transition from stage I (first biopsy) to stage II (second biopsy) was observed.Stage III.Nodular parenchymal regeneration, associated with changes observed in stage I and II. It was found in six patients. The histological picture resembles the biliary type of cirrhosis. There is a clear‐cut correlation between the length of treatment and the stage of the h

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00902.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—The relative distribution of T lymphocyte subsets, as defined by the monoclonal antibodies OKT, was determined by cytofluorimetric analysis in peripheral blood and in cells isolated from liver biopsies of 31 patients with chronic active hepatitis (CAH). The percentage of peripheral blood lymphocytes binding OKT8 (directed against cytotoxic/suppressor T cells) was found to be elevated in patients with HBsAg and HBeAg positive chronic active hepatitis. Patients with CAH who had seroconverted to anti‐HBe, had an increased number of OKT3‐positive cells in their blood, which was directed against a common T cell surface antigen, associated with a decreased number of OKT8 positive cells. Lymphocytes isolated from liver biopsies of patients with CAH presented a general increase of OKT8‐positive cells associated with a decreased number of OKT4‐positive (helper/inducer) T cells. It is likely that OKT8‐positive cells found in liver biopsies represent cytotoxic T cells directed against either viral or liver cell d

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00903.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—Three types of giant mitochondria have been described in hepatocytes, and we have investigated their ultrastructural features and occurrence in alcoholic liver disease. Type I mitochondria are spherical, with a paucity of cristae. Type II are elongated and have long crystalline insertions. Type III are relatively smaller and often bizarre in shape, containing multiple crystalline insertions. We defined megamitochondria as spheroidal giant mitochondria with a diameter roughly more than one third of the hepatocyte nucleus and visible under light microscopy. Type I was the most common form of megamitochondria in livers with ALD. Megamitochondria were present in livers of 58 (27.8%) of 209 consecutive patients with alcoholic liver disease, compared with 1 (0.7%) of a series of 145 patients with non‐alcoholic liver disease. The frequency and occurrence of megamitochondria varied in different types and/or stages of alcoholic liver disease. In particular, livers with alcoholic foamy degeneration had significantly increased frequency and numbers of megamitochondria compared to other patterns of alcoholic liver disease. The ultrastructural studies showed that hepatocytes containing Type I mitochondria frequently had other damaged organelles and extensive focal cytoplasmic degradation. Enzyme histochemistry showed the foamy hepatocytes containing Type I had markedly decreased staining for glucose‐6‐phosphatase and slightly decreased staining for succinic dehydrogenase activities, while the hepatocytes with Type II or III had normal staining. In general, Type I giant mitochondria seem more characteristic to alcoholic liver disease, or conditions that produce similar hepatic morphology. It is particularly seen in alcoholic foamy degeneration and may be part of decompensation of the hepatocytes, while Types II and III occurred in hepatocytes of both alcoholic and non‐alcoholic patients and had preserved

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00904.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—Ninety‐three cases of acute viral hepatitis in adult Lebanese patients were followed‐up prospectively for a period ranging from 6 to 18 months. These included 33 hepatitis A (HAV), 32 hepatitis B (HBV) and 21 non‐A, non‐B hepatitis (NANB) cases. The clinical and seroepidemiologic characteristics of the three types were evaluated. HAV was characterized by a short prodroma (14 days) and IgM levels are within normal limits. The failure to develop chronicity in NANB suggests that the virus of sporadic NANB may be different from that which causes post‐transfusional

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00905.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—Six patients with chronic hepatitis B virus (HBV)‐induced liver disease were treated with human lymphoblastoid interferon. Daily, alternate day or thrice weekly regimens were employed in two, one and three patients respectively. Thrice weekly intra‐muscular injections of 7.5 to 10 megaunits of interferon/m2appeared to be as effective as daily injections in producing inhibition of HBV replication, were associated with fewer side effects and could be continued for up to 3 months. The effectiveness of this regimen in producing long‐term inhibition of viral replication must now be det

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00906.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—The blood supply to regenerative nodules in liver cirrhosis was studied by scanning electron microscopy of microvascular casts. Cirrhotic nodules are surrounded by many arterioles with rich anastomoses that form a perinodular arteriolar plexus: these arterioles connect with sinusoids in the nodules. The portal vein branches, on the contrary, are distorted and compressed by connective tissue. These findings illustrate how the regenerative nodules in liver cirrhosis are mainly nourished by hepatic arterial blood via a perinodular arteriolar plexu

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00907.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

ABSTRACT—A longitudinal follow‐up study has been undertaken in 62 patients with clinicopathologically verified chronic hepatitis with non‐specific reactive histological changes (NSRH) in comparison with 28 patients with chronic persistent hepatitis (CPH), the clinical features of which are quite similar to NSRH. In contrast to the stationary and non‐progressive course of CPH, 45.2% of patients with NSRH, either HBsAg positive or negative, ran a fluctuating course with moderate to marked elevation of SGPT (>200 IU/l). In HBsAg‐positive patients, only those positive for HBeAg and a few negative for both HBeAg and anti‐HBe had fluctuating courses. In addition, patients with apparent clinical and biochemical changes could show histological features of chronic lobular hepatitis (CLH). A few developed chronic active hepatitis and/or cirrhosis on follow‐up biopsy. It is concluded that NSRH is a form of chronic hepatitis different from CPH, but similar to or representing a phase of CLH. It is suggested that NSRH should be categorized as CLH in the classification of chro

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00908.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Book reviewed in this article:Langer, M., Chiandussi, L, Chopra, I. J. and Martini, L. (eds.):The endocrines and the liver.Csomós, G. and Thaler H. (eds):Clinical hepatology

ISSN:0106-9543    

DOI:10.1111/j.1600-0676.1984.tb00909.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY