ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Summary:Twenty Parkinson's disease patients, who had not yet received levodopa, were treated with low-dose bromocriptine. At a mean daily bromocriptine dose of 13.2 mg, 13 patients (65%) improved and had a 32% reduction in the combined score for tremor rigidity and bradykinesia. Adverse effects were frequent, and 25% of the patients were taken off the drug because of nausea or vomiting. After 30 months follow-up, only three patients continued on bromocriptine alone. Ten patients were eventually maintained on low-dose bromocriptine and levodopa-carbidopa, and a clear synergistic effect of bromocriptine in this drug combination was documented in eight patients. Low-dose bromocriptine does not replace levodopa as initial therapy for Parkinson's disease. The potential long-term benefit of the early use of combined low-dose levodopa-dopamine agonist therapy needs to be further studied.

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Summary:The analgesic effect of clomipramine and the possible relationships between the antalgic action and the plasma levels of this tricyclic drug have been studied in 30 patients with chronic pain induced by nervous lesions determining a deafferentation. Twenty of 30 patients treated with clomipramine reported a significant improvement (up to 50%) observed as soon as the 4th day, with few side effects. The pharmacokinetic analysis shows the existence (r = 0.358; p < 0.001) of a relationship between analgesia and plasma levels of clomipramine for each individual patient. This study also indicates a “therapeutic window” of plasma levels between 20 and 85 ng/ml. These results permit discussion of measurement of plasma levels of clomipramine in the treatment of chronic pain.

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Summary:Research in Parkinson's disease has given little attention to the reliability of subjective-qualitative assessment, or to the empirical aggregation of physical signs to supraordinate indexes of motor disturbance. We illustrate methods for examining observer reliability and discuss the importance of reliability to the interpretation of results. Observers rated patients (n = 70) for physical signs (selected Columbia Scale scores), disability stages, and abnormal involuntary movements. Observer agreement was achieved for Columbia scores and disability stages (range of Spearman rho = 0.67–0.95), but not for dyskinesias or dystonic postures. A factor analysis of Columbia scores revealed two indexes of motor disturbance: motor deficiency and tremor.

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1985

数据来源: OVID