ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Summary:The semisynthetic lisuride derivative transdihydrolisuride (terguride, TDHL) is an effective antiparkinsonian drug. In animals, TDHL appears to possess mixed dopamine agonist-antagonist effects, but this may not be the case in man. Single doses of TDHL were given to 21 subjects with parkinsonism. Overall, TDHL 0.25–0.5 mg caused dose-related improvement in parkinsonism for periods of up to 6 h, although 8 of 21 subjects showed no improvement or deterioration with TDHL 0.5–1 mg. In three patients with levodopa-induced psychosis, the addition of TDHL 0.75 mg daily for 5–10 days did not alter the psychotic state. In three subjects with levodopa-induced dyskinesias, the addition of TDHL 0.75 mg daily for 14 days resulted in a slight increase in the severity of involuntary movements. Side-effects of TDHL, sickness and hypotension, were similar to those observed with levodopa. Transdihydrolisuride caused prolonged inhibition of prolactin release, but unlike levodopa did not elevate plasma growth hormone levels. Additionally, TDHL did cause considerable sedation. These results may be due to combined effects of TDHL on nondopamine as well as dopamine neurotransmitter systems, rather than to partial or incomplete dopamine agonist effects.

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Summary:We describe kindred in which affected members had paroxysmal attacks of gait ataxia and other cerebellar symptoms. The mode of inheritance was autosomal dominant. Stress or emotion precipitated attacks. Examination between attacks revealed nystagmus but no other neurologic signs. After adulthood there was no progression of symptoms. Acetazolamide therapy successfully abolished the attacks.

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Summary:Sixteen patients with symptoms of restless legs syndrome and resulting insomnia are included in this study. They were nine women and seven men with a mean age of 50.8 years and with a mean duration of symptoms of 6.3 years. The purpose of the study is to determine the drugs that are useful for the treatment of restless legs syndrome. In 13 patients L-Dopa plus benserazide, in two patients bromocriptine, and in the remaining one patient piribedil were used orally at night ∼1 h before bedtime. Compared with placebo these dopaminergic drugs decreased the times of waking up and staying awake periods at a statistically significant level (p changed between 0.025 and 0.01,ttest). In this susceptibility of CNS there is dysfunction of the dopamine system triggered by sleep, and resting and dopaminergic potentiation by drugs affect the symptoms.

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Summary:The effect of long-term treatment with valproic acid (VPA) on zinc (Zn) metabolism was studied in 15 children with absence seizures. During treatment with VPA the erythrocyte Zn content was significantly lower than that found in controls matched for sex and age. Plasma and urine values of Zn and of copper were within normal limits. It is suggested that the anticonvulsive action of VPA may be mediated through its effect on the metabolism of Zn in the brain and the concomitant changes in the activity of the enzymes glutamic acid decarboxylase and carbonic anhydrase.

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1987

数据来源: OVID