ISSN:0362-5664    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0362-5664    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Clonazepam has been reported to be of some value in the treatment of benign essential tremor in open trials. The efficacy of clonazepam was evaluated in a double-blind placebo-controlled study using up to 4 mg/day. By a variety of objective measures, clonazepam was not found to be an effective form of therapy.

ISSN:0362-5664    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Continuous intravenous infusions of L-Dopa as a treatment for response swings in Parkinson's disease are limited by the insolubility and acidity of L-Dopa. Its methyl ester is a soluble neutral derivative that might be of benefit to these patients, and is examined in the present study in behavioural and biochemical animal models. On intraperitoneal or subcutaneous administration to mice L-Dopa methyl ester was equivalent to L-Dopa in reversing reserpine-induced akinesia and producing contraversive circling behaviour in rats with a 6-hydroxydopamine lesion of the medial forebrain bundle. On oral administration the methyl ester was more active. The administration of L-Dopa or the methyl ester produced equivalent changes in striatal and mesolimbic dopamine, homovanillic acid, and 3,4-dihydroxyphenylacetic acid metabolite levels. We suggest that systemic or subcutaneous infusion of L-Dopa methyl ester to patients who experience response fluctuations may provide a means of maintaining mobility.

ISSN:0362-5664    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Epidemics of epilepsy, a form of mass hysteria, were known in Eastern and Western cultures in the 17th and 18th centuries. A unique situation in the United States during the 19th century was the frontier religious movement, the setting in which the “jerks” occurred. The “falling exercise,” “dancing exercise,” “barking exercise,” “laughing exercise,” and the “running exercise” centered around the excitement involved in the religious revival. During some exercises, people saw “visions,” and exhibited bizarre behavior and sudden jerking motions. During the summers of 1801–1803 on the Kentucky frontier, some pioneers who attended the religious revival camp meetings had convulsions, hallucinations, tremors, jerks, compulsive dancing and “epileptic trances.” Although these have been assumed to be psychological in origin, the epidemiology of the symptoms may correlate with the diagnosis of ergotism. Those affected were usually children and young adults. Symptoms of ergotism include giddiness, fatigue, depression, formications, muscle twitching, tonic spasms, convulsions, delirium, and loss of speech.

ISSN:0362-5664    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Sinemet® is the major antiparkinsonian drug available in the United States, and only recently has it become available in three different doses, 25/250, 10/100, and now 25/100 (mg carbidopa/mg levodopa). The latter dose is specifically designed for supplementary peripheral dopa decarboxylase inhibition (25 mg carbidopa) with low-dose levodopa (100 mg). Since the introduction of Sinemet 25/100, I have encountered five patients who developed generalized maculopapular rashes when the drug was started or substituted for other Sinemet preparations. Prompt cessation of the drug led to resolution of the rash over 3–6 weeks. Since both the carbidopa and levodopa had been used previously without allergic complications in four of five patients, allergy to either of the active drugs seemed unlikely. I suggest that the yellow dye in Sinemet 25/100 is responsible.

ISSN:0362-5664    

出版商:OVID    

年代:1984

数据来源: OVID