ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

In Alzheimer disease (AD), dysfunction in several neuronal systems is associated with alterations in neurotransmitter receptors. Although receptors are important components of normal neural circuitry, their role in the pathophysiology of AD is only beginning to be clarified. For example, despite the consistent loss of presynaptic cholinergic markers in cortex in AD, the pattern of changes in cortical muscarinic cholinergic receptors is unclear, although the density of nicotinic receptors appears to be reduced. In AD, reductions in serotonin, glutamate, and somatostatin receptors also occur in cortex, and an increase in corticotropin-releasing factor (CRF) receptors has been reported. Studies of neurotransmitter receptor alterations in AD are contributing to the characterization of the biology of this disorder and could result in the development of better diagnostic tests and therapeutic agents.

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

Structural analysis of the capillary plexus in the brains of 5 patients with clinical and neuropathological diagnosis of Senile Dementia, Alzheimer Type, revealed a group of striking physical alterations compared with tissue specimens from 5 age-matched controls. Capillary walls were thickened with irregular lumpy, nodulated contours which appeared due, in part, to infiltration of the vascular wall with rounded cell-like bodies. In some cases, these resembled the perikarya of pericytes or monocytes, or their protoplasmic extensions, which were often filled with lipids. In each case, there was no trace of the perivascular neural plexus which regularly invests the microvasculature of the brain parenchyma. The loss of this neural plexus, believed to originate largely from locus ceruleus and the basal forebrain, may be related to the changes in capillary wall structure, and these, in turn, may lead to profound alterations in blood-brain barrier function. We suggest that this subcortically induceddenervation microangiopathymay serve as a pathogenic factor in the development of SDAT.

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

摘要:

γ-Glutamyltransferase (EC 2.3.2.2; γ-GT) may be important in the transport of amino acids or peptides across the blood-brain barrier. γ-GT activities were the same in cortical samples from Alzheimer and age-matched control brains, and there was no correlation between γ-GT and choline acetyltransferase (ChAT) or acetylcholinesterase (AChE) levels, both of which were significantly reduced in the Alzheimer samples. ChAT and AChE activities were significantly correlated in both groups. ChAT showed a negative correlation with age in the controls and a positive correlation in the Alzheimer group. The opposite was true for γ-GT, although the correlations were of low significance. The results do not lend any support to the hypothesis of a defect in the blood-brain barrier in Alzheimer disease.

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1987

数据来源: OVID