ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Although establishing that a patient is suffering from dementia of the Alzheimer type initially reflects a clinician's opinion, neuropathological study is for the present the most definitive examination to confirm the clinical diagnosis of Alzheimer disease. We review several comprehensive publications attempting on a quantitative basis to differentiate the changes occurring with normal aging of the human brain from those indicative of Alzheimer disease. New morphometric data on 5 histopathological lesions in the mesial temporal cortex of 42 subjects indicate that, when multivariate analyses are performed on such microscopic information, a diagnostic prediction about the brain of any unknown individual should indeed be possible with a statistically calculated degree of certainty

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

Twenty-nine patients diagnosed with Probable Alzheimer Disease were administered tests of word, familiar phrases (idioms and proverbs), and novel phrase comprehension. From the early stage of the disease, patients performed worse at understanding familiar phrases than single words or novel phrases. The results uphold common observations that AD patients have difficulty interpreting abstract meanings. Cognitive variables responsible for poor idiom/proverb comprehension and the clinical implications of this new protocol are discussed.

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

摘要:

The cause(s) of Alzheimer disease (AD) remain unknown. Since neurofibrillary tangles and neuritic plaques, a hallmark of AD, are also present in older patients with Down syndrome (DS), a close relationship between the two diseases has been suggested. IgG type of brain reactive antibodies (BRAs) are present in a majority of patients with AD but such studies have not been carried out in adult patients with DS. The present study was carried out to test the hypothesis that if the brain changes in older patients with DS and patients with AD are identical, the occurrence and specificity of BRAs should be similar in both diseases. The frequency of BRAs was studied in sera obtained from 21 patients with AD, 26 older patients with DS, and 20 normal control subjects using electroblots prepared from rat spinal cord proteins. Circulating BRAs were found in 57% of patients with AD, 81% of patients with DS, and 30% of normal controls. However, the pattern of BRA reactivity was different in AD and DS. In AD, antibodies reacted with the 200-kDa subunit of neurofilament triplet singly or in combination with the 150-kDa, 70-kDa or with the associated 62-kDa protein. In DS, BRAs always reacted with the 70-kDa protein, usually in combination with the 200-kDa subunit and, less frequently, in association with the other subunits. No specific pattern of antibody activity was evident in the control group.

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID

ISSN:0893-0341    

出版商:OVID    

年代:1988

数据来源: OVID