摘要:

AbstractAn autopsy case of the unilateral cryptophthalmia syndrome was presented, showing the lack of the eyelids formation on the right and the facial skin being continuous over the right eye. Potter's face, partial cutaneous syndactyly, clitorial hypertrophy, bilateral renal agenesis and absence of uterus were associated, and further laryngeal atresia was noted, leaving a small posterior opening and allowing a survival of only 10 min at birth. Histologic analysis of the right eye revealed that the cyst in the anterior segment was formed by the destruction of the lens itself. The pathogenesis of cryptophthalmia and laryngeal atresia was discussed.

ISSN:0914-3505    

DOI:10.1111/j.1741-4520.1987.tb00687.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractA case of persistent stapedial artery is presented.The patient was a 49‐year‐old man who had suffered from tinnitus in the left ear and bilateral hearing impairment for 20 years. The preoperative audiological examinations showed considerable combined hearing loss, suggesting middle ear anomalies or otosclerosis. An exploratory tympanotomy on the left ear was performed, and complete fixation of the stapedial footplate and a small vessel running vertically on the footplate were observed. By reconstructive surgery using a prosthesis, postoperative hearing improved. The histological examination of the removed portion of the stapes showed an otosclerotic lesion. Cases of persistent stapedial artery found in the literature were discussed from the clinical and embryological viewpo

ISSN:0914-3505    

DOI:10.1111/j.1741-4520.1987.tb00688.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractThe interaction between methylmercury teratogenesis and manifestation of cleft lip and palate (CL(P)) of genetic origin was experimentally investigated in CL/Fr mice. Pregnant mice were given methylmercuric chloride orally on day 10 of pregnancy at doses of 5, 10, 15 and 20 mg/kg. Animals were put to death on day 18 of pregnancy and the fetuses were examined for malformations, especially facial anomalies. About 23% of fetuses manifested CL(P) in the control group. After maternal treatment with methylmercuric chloride, the incidence of fetuses with CL(P) did not remarkably change in groups of 5 mg/kg (about 30%) and 10 mg/kg (about 24%), but decreased significantly (p0.05): This suggested that the decreased incidence of fetuses with CL(P) was not attributable to the preferential mortality of embryos with CL(P). The incidence of isolated cleft palate (CP) was about 1, 5,40 and 80% after maternal treatments of 5,10,15 and 20 mg/kg methylmercuric chloride, respectively, showing the distinct threshold. No significant difference in mercury concentration was observed among normal fetuses, fetuses with CL(P) and with CP within any dose grou

ISSN:0914-3505    

DOI:10.1111/j.1741-4520.1987.tb00689.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractIn the purpose to learn the teratogenic effects of tritium, tritiated water of 50, 75, 100, 125 and 150mCi was injected into the abdominal cavity of pregnant rats individually on days 7, 8, 9, 10 and 11 of pregnancy, respectively, and the anomalies that developed were studied on day 18 of pregnancy. The anomalies occurred at the highest frequency in the cases administered with 100mCi on day 9 of pregnancy, the anomalies combined accounting for 81.3 % of the implanted embryos (100% of the surviving embryos). Among them, cardiovascular anomalies accounted for 68.8 % of the implanted embryos (84.6 % of the surviving embryos). The LD50was 132mCi in cases administered on day 9 of pregnancy.

ISSN:0914-3505    

DOI:10.1111/j.1741-4520.1987.tb00690.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0914-3505    

DOI:10.1111/j.1741-4520.1987.tb00691.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0914-3505    

DOI:10.1111/j.1741-4520.1987.tb00686.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY