ISSN:0271-3586    

DOI:10.1002/ajim.4700050101

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractSkin symptoms of “Yusho” and their change thereafter are described. In the early stage, skin eruptions were the most prominent and impressive features of Yusho. Acneiform eruptions and pigmentation were most conspicuous. With the passage of time, there is some improvement and most patients now have few eruptions, except for the severely intoxicated group. As for blood PCB analysis, the severely intoxicated group who showed intensive skin symptoms showed “pattern A”—a typical specific Yusho pattern. The blood PCB patterns of each patient were stable with no alteration after many years and, on the other hand, the blood PCB concentrations have diminished yea

ISSN:0271-3586    

DOI:10.1002/ajim.4700050102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractA subacute poisoning, “Yusho,” caused by the ingestion of Kanemi rice oil which had been accidentally contaminated with polychlorinated biphenyls (PCBs), occurred in the western part of Japan in 1968.During the past decade, various clinical symptoms of Yusho patients have diminished gradually. However, some of the symptoms and signs, such as pigmentation of the skin, conjunctiva and gingiva, eye discharge, and various nonspecific general symptoms still remain in a number of severely ill patients.In this report, clinical observations of Yusho patients during 1968–78 are briefly rev

ISSN:0271-3586    

DOI:10.1002/ajim.4700050103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractAutopsy findings of 12 patients with Yusho including 2 stillborn babies are reported. Characteristic pathological changes were acne‐like eruptions and cutaneous pigmentation with histological features of follicular hyperkeratosis, dilated hair follicles, and an increase of melanin pigment of the epidermis. In addition to the skin lesions, multiplication of the duct epithelium of the esophageal gland was found in 6 patients. Unusual multiple small foci of myocardial necrosis and fibrosis with basophilic myofibrillar degeneration were found in one patient, suggesting a relation to PCB exposure. Five cases with carcinomas (two involving the liver, two the lung, and one the esophagus) were also found, but their causal relationship with PCB was not certain. Nine cases showed the characteristic gas chromatographic pattern of Yusho, but two cases had the same one as that of healthy control

ISSN:0271-3586    

DOI:10.1002/ajim.4700050104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThe rice oil ingested by the patients with Yusho and their blood, liver, and adipose tissue were analyzed for individual congeners of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). The individual congeners identified were examined for accumulation in the liver of monkeys and rats, inducing activities of benzo[a]pyrene 3‐hydroxylase, benzphetamine demethylase, and DT‐diaphorase in rats, and gravimetric changes of the thymus and liver in rats. Among the six PCB congeners detected in Yusho patients, 2,3,4,5,3′,4′‐hexa‐CB seems to be the compound most related to Yusho judging from its strong enzyme‐inducing activities in the liver and the thymus atrophy and liver hypertrophy caused by feeding it to rats. PCDF congeners identified in the patients' tissues showed a stronger toxicity in rats than these PCBs, exhibiting stronger enzyme induction activities and gravimetric changes of the tissues. These PCDF congeners, especially 2,3,4,7,8‐penta‐CDF, were also very accumulative in the liver. Therefore, they are considered as the most important etiologic agents for the current symptoms and signs

ISSN:0271-3586    

DOI:10.1002/ajim.4700050105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThrough the analysis of polychlorinated biphenyls (PCBs), polychlorinated quaterphenyls (PCQs), and polychlorinated dibenzofurans (PCDFs) retained in the blood of Japanese and Taiwanese patients who had been poisoned by ingesting contaminated cooking oils, in the blood of workers occupationally exposed to PCBs, and in the blood of unexposed individuals, it was strongly suggested that PCDFs might be the responsible compounds for the development of Yusho disease. To confirm this, animal experiments were done. The dermal signs resembling those of Yusho were observed among the cynomolgus monkeys that received a PCDF mixture consisting of PCDF components similar to those in the Yusho oils. In addition, significant thymic atrophy and decreased body weight gain were noted in the rats fed PCDFs. However, the administration of PCBs or PCQs alone failed to cause such signs in the monkeys or rats. As a result, it became clear that PCDFs were the main causative agents in the pathogenesis of Yusho disease.

ISSN:0271-3586    

DOI:10.1002/ajim.4700050106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractFact‐finding surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of silk thread or of paint were carried out. Some of the workers showed higher PCB levels in the plasma than typical Yusho patients. Gas chromatographic patterns of their PCBs were shown to match the pattern of the PCBs to which they had been exposed. Levels of polychlorinated quaterphenyls in their blood were lower than 0.02 ppb. Medical findings were slight compared with typical Yusho patients. From these results, the differences in contamination with PCBs and relevant compounds and in health status between these workers and Yusho patients are discusse

ISSN:0271-3586    

DOI:10.1002/ajim.4700050107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractAn outbreak of PCB poisoning through consumption of the contaminated rice oil in Central Taiwan was investigated. It covered four counties and there were 1,843 cases by the end of 1980. The highest frequency of incidence occurred during the period from March to July 1979. Severity of clinical manifestations was graded, most patients exhibiting mild or moderate severity. The major age group of the outbreak was between 11 to 20 years old. Most of the victims were students and factory workers. The amount of PCB intake in each victim was estimated to be 0.7 to 1.84 gm and the latent period from the time of intake to the onset of clinical manifestations was approximately three to four months. The patients' blood PCB concentrations ranged from 3 to 1,156 ppb. In 613 patients, 44.37% (272 patients) had PCB levels of 51–100 ppb, and 27.57% (169 patients) had levels over 100 pp

ISSN:0271-3586    

DOI:10.1002/ajim.4700050108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThis paper describes in detail the dermatological, medical, and laboratory findings of patients poisoned with PCBs and related compounds in Taiwan. Together with their symptoms, their skin lesions as well as their hematological, immunological, and other clinical features are explained. A grading of their clinical severity was tried, and its possible association with PCB concentrations in their blood was examined but could not be demonstrated. Various treatments have been applied but without notable success. Even so, a follow‐up study of patients one year later showed that about 38% of patients were somewhat clinically improved, while 54% were not altere

ISSN:0271-3586    

DOI:10.1002/ajim.4700050109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY

摘要:

AbstractThirty‐five patients out of the 2,000 PCB‐poisoned cases that occurred in central Taiwan in 1978 were neurologically studied in 1980. Neurological manifestation included clinical peripheral sensory neuropathy in about two thirds of the cases, headache in two‐fifths and dizziness in one‐third. There was no relationship between the blood PCB concentration in patients with neurological manifestation and those without. Sensory nerve conduction velocity was reduced in about half of the cases and motor nerve conduction was delayed in about one‐third of the cases, which suggested that PCB poisoning apparently affected not only sensory nerve conduction but also motor nerve conduction. Normal CSF PCB concentrations (0.5–2.3 ppb) indicated that PCB had difficulty penetrating the blood‐brain barrier. A mildly abnormal EEG pattern was found in one fifth of twent

ISSN:0271-3586    

DOI:10.1002/ajim.4700050110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1984

数据来源: WILEY