摘要:

A 66-year-old female patient is presented in whom a rapidly growing tumour developed on the glabella. Light and electron microscopy confirmed Merkel cell carcinoma. Flow cytometry (FCM), performed of a tumour specimen, yielded multiple aneuploid stem lines. The FCM data are discussed with regard to the histological features and the biological behaviour of the tumour.

ISSN:1018-8665    

DOI:10.1159/000249486

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Although there is occasionally remarkable accumulation of mucin in the skin lesion of dermatomyositis, no special attention has been paid in regard to mechanisms underlying it. We carried out histochemical and biochemical studies on materials obtained from one case of dermatomyositis, who showed the presence of abundant mucinous material stainable with alcian blue between the collagen bundles throughout the lesional dermis. The major component of the ground substance was identified to be hyaluronic acid. The activity of N-acetyl-β-glucosaminidase, exoglycosidase that degrades hyaluronic acid in serum of the patient, was equivalent to that of controls. However, heparan sulfate was greatly increased in the urine of the patient in comparison with that of the normal controls in which the major components were chondroitin 4-sulfate and chondroitin 6-sulfate. We think that the increase of hyaluronic acid in the lesional dermis is due to an excess production by the fíbroblasts under some immunological stimulation, although its relation to the increased heparan sulfate excretion into the urine of the patient is obscur

ISSN:1018-8665    

DOI:10.1159/000249487

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

By modifying the blood supply in the upper part of the dermis, the colour of the skin is changed by any material in contact with it. This is a great difficulty when we want to measure the colour intensity in erythema or blanching. To avoid this problem, we designed and built a device which measures the skin reflectance value without any contact with the skin. The use of this device on man to study the skin blanching after application of dermocorticoids allows us to determine the more potent drug among a series (clobetasol propionate) and, for a given drug (betamethasone), the more efficient preparation (oil-in-water emulsion). The study of the effect of increasing irradiation doses of ultraviolet light shows that the sensitivity of the device is equivalent to that of the clinical assessment and that the relationship between the irradiation dose and the skin reflectance is sigmoidal.

ISSN:1018-8665    

DOI:10.1159/000249488

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Gonoblennorrhoea adultorum (GA) still occurs in spite of contrary statements. During the last 10 years, 4 cases were seen in the Munich Clinic of Dermatology (constituting 0.19% of all patients with gonorrhoea). While the conjunctivae alone were involved in 3 of them, in 1 the cornea showed alterations as well. Thus, the disease has not lost its potential danger. Yet the newer cephalosporins seem to cure GA rapidly, even if given in a single dose (together with local treatment).

ISSN:1018-8665    

DOI:10.1159/000249489

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

To determine the correlation between the lymphocyte transformation test (LTT) with phytohemagglutinin (PHA) and the clinical forms of American leishmaniasis (AL), duration of the disease and reaction to leishmanin, the authors studied 12 patients and compared them to 25 unaffected individuals. The ulcerated cutaneous form of the disease was observed in 4 patients, the ulcero-nodular lymphangitic form in 1 the mucous cutaneous form with destruction of the nose in 6, and the verrucous form in 1. General patient condition was satisfactory and the Montenegro reaction macroscopically positive with infiltrations of 5–15 mm in diameter. The results revealed no evidence of immunodeficiency among patients. No correlation was observed between clinical forms, duration of the disease and Montenegro reaction and LTT results. LTT with PHA does not appear to be an adequate indicator of the cell immune system in AL case

ISSN:1018-8665    

DOI:10.1159/000249490

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

An immunological study was performed in a 16-year-old boy affected with Papillon-Lefèvre syndrome (PLS) and recurrent staphylococcal cutaneous infections. A defect of neutrophil intracellular killing of Staphylococcus aureus and a decreased lymphocyte proliferative response to phytohaemagglutinin were detected. The possible role of these alterations in promoting recurrent infections in PLS is discussed

ISSN:1018-8665    

DOI:10.1159/000249491

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A 69-year-old man who 1 year previously got the diagnosis primary biliary cirrhosis presented a highly pruritic rash on the knees, elbows and in the inguinal region. Both clinically and histologically this was compatible with dermatitis herpetiformis, and dapsone treatment confirmed this. He was found to have jejunal atrophy, and after 1 year with gluten-free diet, biopsy showed almost full restoration of the villous pattern. He then only rarely had any skin problems.

ISSN:1018-8665    

DOI:10.1159/000249492

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A study was conducted to compare the Staphylococcus aureus skin colonization of 21 patients with atopic dermatitis (AD) and 22 healthy controls. It was found that the total aerobe count (total CFU/cm2), the S. aureus fraction thereof and the S. aureus carrier frequency were significantly higher in apparently normal skin of AD patients than in healthy individuals. In addition, compared to normal skin of patients S. aureus density was 100 to 1,000 times higher in the 3 different kinds of lesional skin (dermatitic, lichenified and impetiginized sites). 190 S. aureus strains isolated from the skin of AD patients were tested for sensitivity to 5 topically used antibiotics and the results reported. Besides the biological consequences for the person affected by AD this severe colonization with S. aureus is of epidemiological importance. Several outbreaks of S. aureus infections by dispersal from dermatitic skin have been described. Therefore some preventive and therapeutic aspects are discussed.

ISSN:1018-8665    

DOI:10.1159/000249493

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A controlled trial of contact allergen therapy of alopecia areata (AA) using squaric acid dibutyl ester (SADBE) was performed on 17 patients. The right side of the patient’s scalp was treated and the left side acted as an untreated control. Minimal signs of terminal hair growth were present in only 3 patients after 8–12 weeks of therapy. A majority of patients experienced adverse effects which led to the early withdrawal of 2 patients and the premature termination of the trial. We do not recommend the use of SADBE in the treatment of

ISSN:1018-8665    

DOI:10.1159/000249494

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Epithelioid sarcoma is a rare malignant tumor of the soft tissues with particular clinical and anatomicopathological characteristics. Histologically it is characterized by the presence of particular epithelioid cells. After a description of a recently observed case, the authors present a synthesis of the literature on the subject, paying particular attention to the clinical and histological aspects which facilitate an early and correct diagnosis.

ISSN:1018-8665    

DOI:10.1159/000249495

出版商:S. Karger AG    

年代:1985

数据来源: Karger