ISSN:1018-8665    

DOI:10.1159/000249283

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000249284

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Skin blisters at different stages were taken from 4 patients with bullous pemphigoid and studied mainly by scanning electron microscopy. The under-surface of the roof of the newly formed blisters was composed of columnar or cuboidal epidermal cells. Their intercellular space was dilated. Most of the cells were degenerated and shed off into the blister fluid. The under-surface of the roof of the fully developed blisters was composed of flattened epidermal cells which were polygonal in shape. These findings suggest that the basal cells are degenerated and shed off into the blister fluid, so that the prickle cells become flattened and directly face the blister fluid during blister formation.

ISSN:1018-8665    

DOI:10.1159/000249285

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

It has been postulated that epidermal Langerhans cells (LC) are essential for induction and elicitation of contact sensitivity (CS) to simple chemical allergens. Although the precise role of LC in CS has not been determined, recent reports have focused on a function for LC in the presentation of antigen to T lymphocytes. To investigate this possibility, the distribution of allergen on the epidermal LC of inbred strain 13 guinea pigs was observed by the immunofluorescent method using antibodies against la antigen and hapten. 2,4-Dinitrophenyl groups were found to be localized on/in Ia-positive epidermal LC of the animals following skin painting with 2,4-dinitrochlorobenzene. This finding is discussed in relation to the role of LC as antigen presenting cells in CS.

ISSN:1018-8665    

DOI:10.1159/000249286

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

41 cases with scarring alopecia seen from 1979 to 1983 were analyzed and differentiated. After exclusion of 7 cases with lichen planopilaris, of 5 cases with discoid lupus erythematosus, of 2 cases with scleroderma, and of 1 case with folliculitis decalvans, there remained 26 cases. The clinical histological and direct immunofiuorescence (DIF) findings in these patients suggest that pseudopelade of Brocq might be a distinct disease unrelated to other known types of scarring alopecia. The histopathology is characteristic, and shows the following features: little or only moderate lymphocytic infiltrate, absence of significant follicular plugging, and absence or decrease of sebaceous glands. DIF is negative, occasionally only IgM can be found at the basement membrane. The course of the disease is slowly progressive (in spite of little or no visible erythema), becoming eventually stationary after several years and resulting in a more or less severe permanent hair loss.

ISSN:1018-8665    

DOI:10.1159/000249287

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Sixty-seven out of 100 kidney transplant recipients treated with cyclosporin and methylprednisolone were evaluated for the presence of dermatological manifestations. Only 2 patients had no dermatological lesions; 80% had iatrogenic lesions, 38% infectious, 13% miscellaneous, 3% cancerous lesions, while 28% had cutaneous manifestations related to previous uremic state. Most of the lesions concerned the pilosebaceous unit: hypertrichosis (60%), epidermal cysts (28%), pilar keratosis (21%), acne (15%), folliculitis (12%) and sebaceous hyperplasia (10%). Among infectious manifestations, viral lesions were the most frequent and were very severe in the first month after transplantation. Two patients developed a squamous-cell epithelioma and a probable cutaneous lymphoma, respectively.

ISSN:1018-8665    

DOI:10.1159/000249288

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The interincisor distance, the vertical lip distance, and the horizontal oral distance were measured in 68 patients with generalized scleroderma and in 66 healthy individuals. Interincisor distance and vertical lip distance were decreased in scleroderma (p < 0.001 and p < 0.001). Vertical lip distance and horizontal oral distance provided clinically a clear differentiation between minor and major affection (p < 0.001 and p < 0.001), while the interincisor distance provided a weaker differentiation (p < 0.05). The horizontal oral distance correlated with the duration of scleroderma (r = ––0.289, p < 0.05), and the vertical lip distance tended to do so (r = ––0.208, n.s.). In healthy individuals interincisor and vertical lip distances decreased significantly with age (in males only), while the horizontal oral distance showed no significant decrease. In conclusion, interincisor and vertical lip distances are preferable for diagnosis and the horizontal oral distance for follow-up of facial scleroderma. If only one vertical parameter is wanted, the authors prefer the vertical lip distance to the interincisor d

ISSN:1018-8665    

DOI:10.1159/000249289

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

A patient with clinically and histologically typical urticarial vasculitis has been treated with 0.5 mg of colchicine three times per day. This treatment resulted in both disappearance of urticarial skin lesions and amelioration of severe systemic symptoms such as abdominal pain, fever and arthralgia. Colchicine is proposed as an effective therapeutic agent for urticarial vasculitis if other drugs are ineffective, poorly tolerated or contraindicated.

ISSN:1018-8665    

DOI:10.1159/000249290

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

A new iontophoretic device was utilized in the treatment of hyperhidrosis axillaris (5 patients), hyperhidrosis manuum (12 patients) and hyperhidrosis pedum (10 patients). Unilateral treatment was carried out daily for 3 weeks. Degree of sweat inhibition was assessed quantitatively in relation to the untreated control side by means of hygrometry and also estimated by a colorimetric method. In 3 patients with palmar hyperhidrosis and in 2 patients with plantar hyperhidrosis sweating returned to normal levels, thus hyperhidrosis was completely curbed. A moderate reduction of sweat rates was induced in 4 patients on palms and in 3 patients on soles. In the remaining group sweat inhibition was only slight. In treatment of palmo-plantar hyperhidrosis side effects were minimal. Axillary hyperhidrosis was only moderately reduced in some patients. Skin irritation due to iontophoresis posed a problem.

ISSN:1018-8665    

DOI:10.1159/000249291

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Two cases of mercury poisoning with predominantly dermatological symptoms are reported. The mercury intoxication was caused by the application of an over-the-counter metallic mercury ointment. The calculations of mercury excretion suggest strongly that cutaneous absorption could have been a significant route of entry.

ISSN:1018-8665    

DOI:10.1159/000249292

出版商:S. Karger AG    

年代:1986

数据来源: Karger