摘要:

The natural history of psoriasis was studied through a questionnaire survey of 5,600 patients throughout the United States. The mean age of onset of psoriasis was 27.8 years. 36% of the respondents reported familial occurrence of the disease. At the time of study, the lower extremities were indicated as being the most often affected; trunk, elbow, and scalp were next, knee and face were cited less frequently. Fingernails were involved in half of the patients at some time during the period of their disease. In the majority of patients, hot weather and sunlight had a beneficial effect. One third of the females also indicated improvement during the course of pregnancy. Remissions were reported in 39% of the patients.

ISSN:1018-8665    

DOI:10.1159/000251595

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Proteoglycans – high molecular polysaccharide-protein-complex compounds – are very important in vital intracellular and extracellular metabolic functions. Disturbances of their regulatory mechanisms are followed by an increase of their rate of biosynthesis. This obviously causes a partially irreversible damage in the connective tissue of the skin which is clinically and morphologically visible, especially in the so-called collagen diseases. Examination of the metabolism of the mucopolysaccharides of the skin is made possible by the quantitative estimation of the mucopolysaccharides in the urine. An increased elimination of the proteoglycans is discussed as well as the value of the met

ISSN:1018-8665    

DOI:10.1159/000251596

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

An ultrastructural study of the dermis in a case of acrogeria is presented and compared with a healthy control of same age and sex. The overgrowing orceinophil material was mainly pseudoelastic. The collagen was hypoplastic and mostly immature. Inside and outside the fibroblasts a lot of a granulofilamentous substance intermingled with pseudoelastin and immature collagen was observed. Fibroblast cytoplasm was often distended by ergastoplasmic vacuoles filled with granulo filamentous substance and contained numerous pseudomyelinic bodies. These abnormalities suggest that acrogeria might be a fibroblast disease.

ISSN:1018-8665    

DOI:10.1159/000251597

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251598

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A transepidermal elimination of junctional nests could be demonstrated in 8 out of 65 junctional active nevus cell nevi (i.e. in 12%).

ISSN:1018-8665    

DOI:10.1159/000251599

出版商:S. Karger AG    

年代:1974

数据来源: Karger