ISSN:1018-8665    

DOI:10.1159/000250736

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A pronounced vitiliginous reaction developed at the sites of MER/BCG injections given as an adjuvant immunotherapy to a patient with malignant melanoma. To our knowledge, this is the third report on patients exhibiting vitiligo apparently induced by immunotherapy and the first in association with MER. This association may be a sign for an antimelanocytic effect and may offer a further confirmation for the autoimmune nature of vitiligo.

ISSN:1018-8665    

DOI:10.1159/000250737

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The human dermoepidermal anchoring fibrils, the oxytalan fibers, and the elaunin fibers have been related with dermoepidermal adherence. In the present work their ultrastructure and origin are studied. The similarity between the segment long-spacing tropocollagen molecular aggregates and the anchoring fibrils band patterns is evidenced. This fact supports the concept that the anchoring fibrils may be formed by a mechanism of side by side tropocollagen molecular aggregation after its polar binding to the basement lamina. The oxytalan fibers were studied in the superficial dermis, and their direct continuity with the elaunin fibers was demonstrated. The role of these fibers in the dermoepidermal mechanical adhesion is discussed.

ISSN:1018-8665    

DOI:10.1159/000250738

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The differentiation of photoallergic contact dermatitis by 3,3′, 4′, 5-tetra-chlorosalicylanilide from phototoxic contact dermatitis by 8-MOP in guinea pigs was studied by skin window technique. Based upon the results, it may be concluded that the photoallergic reaction can be differentiated from phototoxic reaction by the appearing pattern of basophilic leukocy

ISSN:1018-8665    

DOI:10.1159/000250739

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Current concepts incriminate a cell-mediated mechanism in the pathogenesis of mucocutaneous lesions of Behçet’s disease. However, such a mechanism alone fails to explain various aspects of hyperreactivity response which is a unique feature manifested with lesions similar to those occurring spontaneously in the disease. 19 patients with active Behçet’s disease have been investigated for possible mechanisms other than cell mediated which may be involved in the process. Beside cell-mediated mechanisms there were indications that polymorphonuclear leucocytes and mast cells may play part in the process. Further study of these two aspects may open a new approach in the understanding and possibly in the treatment of this di

ISSN:1018-8665    

DOI:10.1159/000250740

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Recently, there has been a sharp increase in the number of leprosy patients in The Netherlands, due to an increased immigration from Surinam where leprosy is hyperendemic. The patients registered at the Dermatological Department of the University of Amsterdam during the years 1972–1976 were reviewed. It was found that 28% of the untreated patients had recently suffered a relapse. A substantial percentage took the medication irregularly or discontinued treatment prematurely and quite a few patients required other types of treatment besides chemotherapy, such as surgical treatment and physiotherap

ISSN:1018-8665    

DOI:10.1159/000250741

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The results of treatment of the group of leprosy patients at the lepromatous side of the leprosy spectrum registered at the Department of Dermatology of the University of Amsterdam in the years 1950–1976 were studied. The average duration of treatment to obtain bacteriologically negative skin biopsies in patients who were untreated at the time of registration, was 5 years. A substantial number of patients suffered a relapse; the main reasons for these relapses were discontinuation of treatment and DDS treatment in low dosag

ISSN:1018-8665    

DOI:10.1159/000250742

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Investigations have been performed on the effect of benzoyl peroxide on skin surface lipids by direct lipid extraction with petrol ether and quantitative determination. Though there was no change after 1 week treatment, after 4 weeks a significant reduction of the casual level as well as the replacement sum could be observed.

ISSN:1018-8665    

DOI:10.1159/000250743

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Ro 10-9359 is a retl·noic acid derivative, selected for study because of a better tolerance than retinoic acid, shown in animal experiments. Earlier clinical experience has proved Ro 10–9359 to be an extremely potent antipsoriatic drug. The well-known association between psoriasis and pustulosis palmoplantaris was a motivation to evaluate Ro 10-9359 also in the last-mentioned disease, which is notoriously known to be resistant to treatment. In this study 30 patients were given either 75 mg/day of Ro 10-9359 or 200 mg twice every week according to a randomized pattern. All patients had suffered from the disease for at least 2 years without any spontaneous remission during the year preceding the trial. After a treatment period of about 2 weeks with Ro 10–9359 hyper-keratotic scales had usually disappeared, and 2 weeks later there were in general significantly less pustular lesions. The treatment continued for 8 weeks, and at this time the average reduction of the number of pustules was 80%. The daily dosage seemed to give better results and was also better tolerated than was the twice-weekly dosage. Side effects were common, but generally mild. On average, the remission lasted 1 month after cessation of the

ISSN:1018-8665    

DOI:10.1159/000250744

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A clinical and histopathological description is given of a number of lesions in 4 patients, mainly caused by picking at the skin. The name dermatotillomania is proposed for this group of lesions.

ISSN:1018-8665    

DOI:10.1159/000250745

出版商:S. Karger AG    

年代:1979

数据来源: Karger