ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04534.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04535.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Plasma vasopressin was measured by radioimmunoassay in eight normal subjects and in six patients with hypercalcaemia. Vasopressin levels were significantly elevated in the hypercalcaemic patients, although urine osmolalities were lower than in controls. This finding is consistent with a renal resistance to the action of endogenous vasopressin in hypercalcaemia.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04536.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Hypercalcaemia occurring after ten weeks of immobilisation was observed in four adult patients all of whom had had prior renal failure sufficient to require renal dialysis. In all patients parathyroid hormone levels were normal or low and in three plasma 1,25(OH)2D3levels were low. These findings are consistent with immobilisation induced increases in bone calcium resorption. Renal excretion of calcium may have been impaired by renal dysfunction resulting in hypercalcaemia and suppression of plasma PTH and 1,25(OH)2D3levels. Resolution of the hypercalcaemia was associated with remobilisation. Parathyroidectomy is inappropriate treatment.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04537.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:A comparison was made of insulin secretion in response to i.v. glucose between non‐insulin dependent diabetics with and without severe microangiopathy. During i.v. glucose tolerance testing those with complications had significantly lower serum insulin concentration (at 40 and 60 min 15.2 ± 2.9 and 11.7 ± 2.5 mll‐1 respectively) than those without (26.1 ± 4.7 and 24.3 ± 3.6 mU‐1, p<0.01). The differences were also significant when insulin increment above basal was determined. All subjects had raised plasma beta‐thromboglobulin concentration (indicating increased tendency to platelet aggregation), but with no significant difference between the two groups. There was also no difference in fasting glucose, kg values, HbAI or blood viscosity. We conclude that non‐insulin dependent diabetics with severe microangiopathy have significantly reduced insulin secretory capacity in response to i.v. glucose when compared with

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04538.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:A fluid phase radioimmunoassay (RIA) has been established for the detection of circulating anti‐glomerular basement membrane (GBM) antibodies. Antibodies were detected by binding with a collagenase solubilised, immunochemically purified, radiolabeled extract of human particulate GBM. Sera from 108 patients with a variety of histological types of glomerulonephritis (GN) were assessed for the presence of antibodies. Likely positive sera were those from patients with clinical features of rapidly progressive glomerulonephritis (RPGN) with crescentic or diffusely proliferative GN and linear staining of their GBM's with IgG. Thirty one of 35 sera from such patients were positive in the RIA. Sera from 14 patients with RPGN but with granular IgG deposition (i.e. immune complex related GN) were all negative for anti‐GBM antibodies as were sera from 59 patients with a variety of non‐crescentic non RPGN without linear IgG. Comparison of the RIA with conventional indirect immunofluorescence (IIF) showed that the RIA had a higher detection rate of antibodies in likely positive sera (19/21 RIA: 16/21 IIF) lower false positive detection rate with sera from patients without GN (0/26 RIA: 2/26 IIF) and was three to four times more sensitive in serial dilution st

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04539.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04540.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:The aim of this trial was to assess whether early crossover induction chemotherapy would improve the complete response rate in patients with small cell lung carcinoma. Tumour markers were defined in all 48 patients at diagnosis. The patients were reassessed after three and six cycles of chemotherapy and classified as having either complete, partial or non response of tumour on each occasion.Initial induction therapy consisted of cyclophosphamide, vincristine and adriamycin (T1). The therapy of the patients with no tumour response was changed to a regimen (T2) consisting of VP16‐213, procarbazine, CCNU and high dose methotrexate with folinic acid rescue. The patients with partial tumour response were randomised to receive either T1 or T2, while patients with complete tumour response continued with T1.In those patients classified initially as having partial tumour response, crossover chemotherapy did not improve tumour response or survival. Similarly, in patients with no tumour response there was not an acceptable improvement.We conclude that non cross resistant crossover chemotherapy using these drug regimens confers no added benefit when compared with continuing the initial therap

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04541.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04542.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Wet aerosol and metered dose inhaler (MDI) modes of inhalation of salbutamol were compared in ten asthmatic patients with severe, reversible airways obstruction and in ten chronic bronchitic patients with severe, poorly reversible airways obstruction. The responses to cumulative doses to 800 μgm (8 times 100 μgm) by MDI and 10 mg (4 times 0.5 ml of 0.5% standard solution) by wet aerosol were studied. From maximum expiratory flow‐volume curves, measurements were made of FEV1, FVC, PEFR, Vmax 50% and Vmax 75%, and pulse and blood pressure responses to cumulative doses of salbutamol were measured. In both groups of patients there was no significant difference between the two modes of inhalation either for each treatment interval or for the maximal response in any of these indi

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04543.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY