摘要:

Summary:In 1505 patients with acute myocardial infarction (Ml) pericarditis was diagnosed most often in those with anterior transmural ECG changes. Those with pericarditis had a significantly greater hospital mortality and peak serum lactic dehydrogenase (LDH) levels and a greater incidence of left ventricular failure (LVF).The patients reported here1and our methods of study2, 4have been described.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03245.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:In 1 505 patients with acute myocardial infarction (Ml) serious ventricular arrhythmias were commoner in those with transmural ECG changes, and were associated with an increase in mortality and in the incidence of left ventricular failure (LVF) as well as higher peak serum lactic dehydrogenase (LDH) levels. Arial fibrillation (AF) occurred more often in older patients and in those with LVF and clinical evidence of pericarditis.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03246.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:An assessment of the side effects of therapeutic doses of tricyclic anti‐depressant drugs was attempted in 32 patients with depressive illness. The patients studied had no evidence of clinical heart disease or hypertension and were not receiving any other drugs.Moderate increase in heart rate and mild prolongation of atrioventricular conduction occurred. No significant effect on the corrected QT interval or blood pressure was found. There was no correlation between the increased heart rate, prolongation of the atrioventricular conduction time (PR interval) and plasma nortriptyline levels measured in 20 out of 32 patient

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03247.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The Waikato Hospital experience of women admitted or seen in the Cardiology Outpatient Clinic who were under the age of 40 and whose diagnosis was a recent acute coronary occlusive episode was reviewed. It was found that there were nine admissions in eight women in this category between December 1971 and November 1973, plus one further patient who was seen with a recent acute ischaemic episode as an outpatient. The histories of these patients were reviewed and their risk factors surveyed. Of the nine women in the study, seven were taking oral contraceptives.As opposed to previous studies, not all the women in this study showed risk factors other than oral contraceptive usage. Three patients in this group taking oral contraceptives and who were thought to have definite coronary ischaemic episodes had no other major risk factor though two of the three were obese. It is thought probable that oral contraceptives containing oestrogens should be considered as a coronary risk factor in young women.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03248.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The effect on blood pressure of high (400 mg/day‐S400) and moderate dose (200 mg/day‐S200) spironolactone and chlorthalidone (100 mg/day—C100), given in a random double‐blind manner was related to plasma renin activity and plasma volume in 38 essential hypertensives.The fall in pressure from a control of 154/103 mm Hg was essentially the same after four weeks of each drug—S400 ABP 24/13 mm, S200 18/9 mm, C100 17/12 mm (allP<0–001).Twelve of 37 patients (32%) had low initial renin, but this appeared as responsive to the chlorthalidone stimulus as that of the normal renin group. The anti‐hypertensive effect of all regimens was unrelated to plasma renin activity.Plasma volume was significantly lowered at the end of each treatment period, but the decline could not be correlated with blood pressure effects. Patients with initially low plasma volume were more likely to respond to S400 (r= 0.545,P<0.01), whereas the anti‐hypertensive effect of the S200 and C100 regimens was independent o

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03249.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:An interaction of bile with erythromycin lactobionatein vitrohas been demonstrated. The major bile components involved in this interaction have been shown to be the bile salts. The nature of the bile salt‐erythromycin interaction has been investigated.The way in which an interaction between bile salts and erythromycinin vivomight lead to the hepatic dysfunction and cholestasis associated with some instances of erythromycin therapy is discusse

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03250.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Urinary adenosine‐3′, 5′‐cyclic monophosphate was measured in 14 patients with hypercalcaemia not caused by primary hyperparathyroidism. Increased levels were found in patients with malignant disease without bone metastases and believed to be examples of paraendocrine syndrome. Decreased levels were found in patients with meta‐static carcinoma involving bone, and in patients with multiple myeloma, lymphoma and immobilisation after fracture. Results obtained during treatment for hypercalcaemia are described in three patients.In two hypercalcaemic patients (one with hyperthyroidism and one with breast cancer with bone metastases) normal levels were found.This measurement is a useful substitute for assay of serum parathyroid hormone and is of value in the diagnosis of hypercalcaemia, in monitoring effects of treatment and in revealing underlying m

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03251.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Urinary adenosine 3′ 5′‐cyclic monophosphate (cyclic AMP) was assessed by a competitive protein binding method in 19 patients with primary hyperparathyroidism (PHPT) and in 15 control subjects. The mean value of 6.6 ± S.E. 0.64 μM per 24 hours for the patients with PHPT was higher (P<0.001) than the mean control value of 3.2 ±24μM per 24 hours. In all hypercalcaemic patients without renal insufficiency, urinary cyclic AMP excretion was more than 4 μM per 24 hours and decreased in the 15 patients investigated after parathyroidectomy. In a normocalcaemic hyperparathyroid patient and in three hyperparathyroid patients with renal insufficiency, urinary cyclic AMP was less than 4 μM p

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03252.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Cellular immunity has been studied by means of lymphocyte response to PHA, delayed hypersensitivity and skin window responses in 23 patients with myeloma (14 1gG, 9 1gA) and 14 patients with macroglobulinaemia.In the myeloma patients, 14% had abnormal PHA response and 29% were anergic. In those with macroglobulinaemia, 29% showed abnormal PHA response and 57% were anergic. In myeloma, the abnormal PHA response was due to a serum inhibitor.Abnormal skin window responses were present in 75% of the patients with myeloma, but only 22% of those with macroglobulinaemia. All the myeloma patients with anergy had abnormal skin windows but this correlation did not exist in macroglobulinaemia.No correlation was found between the paraprotein concentration and anergy, PHA response or skin window.The results support the conclusion that myeloma is predominantly associated with an abnormal skin window (inflammatory) response and macroglobulinaemia with intrinsic abnormalities of cellular immunity. When anergy and abnormal PHA response are present in myeloma, it appears to be attributable to an effect of the paraprotein and not an intrinsic abnormality of lymphocytes.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03253.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:One hundred and twenty‐one regular soldiers between the ages of 18 and 34 years, who had lived and worked under identical conditions for the two previous years were examined. All subjects with respiratory symptoms of wheeze, dyspnoea, persistent cough or sputum were excluded. Smoking,per se, was not a reason for exclusion. Eighty‐three “respiratorily fit” men, comprising 47 Maoris and 36 Europeans, were studied to see whether height, weight or obesity could account for the ethnic differences in lung function.The forced vital capacity in the Maoris was found to be about 9% lower than in the Europeans. The one‐second forced expiratory volume of the Maoris was about 8% lower than in the Europeans. No significant difference could be found in the peak expiratory flow rates between the two ethnic groups.The only significant physical difference found between the two ethnic groups was that the Maoris were heavier for their height than the Europeans. Statistical tests showed that neither weight nor an obesity index accounted for the ethnic differences in lung function. Full laboratory investigation of these ethnic differences is re

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03254.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY