ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03574.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03575.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:Complications involving the oropharyngeal mucosa occur commonly in patients receiving chemotherapy for cancer. This communication presents a classification and description of the principal changes encountered, and suggests guidelines for their management.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03576.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:A review of 205 abdominal computed tomographic (CT) scans in 83 patients with gastric or ovarian neoplasms was performed in order to assess their contribution to management. Assessment of scan accuracy was based on results of invasive procedures, clinical data, and double‐blind re‐reporting. Scans appeared to be of greater value in patients with ovarian rather than gastric neoplasms (p<0.001), and in patients undergoing clinically‐indicated rather than routine scans (p<0.001). No clinical benefit accrued from the use of pre‐treatment scans. Overall accuracy of scanning was judged to be significantly greater for the ovarian than the gastric group (p<0.001), while concordance of scan reports with re‐reporting was also greater in the ovarian group (p<0.001). The data indicate the inherent limitations of the CT scan and the high degree of subjectivity in its interpretation, particularly when used in the follow‐up of patients with known or suspected recurrent gastric cancer. CT scanning remains a potentially useful adjunct to clinical assessment of patients with intraperitoneal malignancy, but should not be regarded as obviating the need for clinical judgement in managemen

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03577.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:Serial bone scans, x‐rays and records of bone pain were reviewed in order to determine the relative contributions of these parameters in the assessment of response of bone metastases to treatment. Twenty‐seven patients with abnormal bone scans due to metastatic breast cancer were studied. Ten of the patients showed an early temporary flare on bone scan including five with apparent new lesions. Confirmation that such new lesions did not denote progressive disease was provided by subsequent improvement in symptoms and reduction in intensity and number of lesions on a follow‐up bone scan, without any change in systemic therapy. Serial x‐rays were found to be unreliable as a sole method for assessing response to therapy or disease progression, as in only seven of the 27 patients could a definitive radiological assessment of response be made. In only one patient did x‐rays improve the accuracy of the scan by distinguishing between a healing flare and progressive disease. In contrast, this distinction was made in seven of the 10 patients on the basis of improvement in bone pain at the time of the flare. The other 3 patients had no bone pain prior to therapy or at the time of the flare. Tentative response criteria incorporating bone scan, x‐ray and symptoms are suggested. The criteria incorporate recognition of the fact that new lesions appearing on a bone scan within six months of initiation of therapy may comprise part of a healing fla

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03578.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:Seven cases of analgesic nephropathy due to excessive ingestion of paracetamol are reported. None of these patients had been taking any other analgesic. All had radiological features of papillary necrosis. With the increasing use of paracetamol as a mild analgesic it is necessary to be aware of the possibility that paracetamol may induce analgesic nephropathy.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03579.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:Serum angiotensin converting enzyme (ACE) activities were determined in patients with different types of inflammatory disease of the gastrointestinal tract. in patients with peptic ulcer, and in healthy volunteer subjects. ACE activity in serum was measured by itsin vitroability to cleave hippuric acid from the synthetic tripeptide hippuryl‐L‐histidyl‐L‐leucine. The hippuric acid so formed was quantified by high performance liquid chromatography and results are expressed as nmol hippuric acid producedlml plasma/min. ACE activity was 27.4 ± 7.7 (mean ± SD, n = 37) in control subjects and was not related to age or sex. Compared to controls, patients with ulcerative colitis had similar ACE values (26.5 ± 7.7, n = 16) while, surprisingly, there was a significant (p<0.01) increase in the enzyme in those with active peptic ulcers (33.8 ± 8.8, n = 21) irrespective of whether the site of ulceration was gastric or duodenal. In a mixed group of patients with active and inactive Crohn's disease, ACE activity (24.8 ± 7.2, n = 19) was not different from controls. However, ACE activity was significantly (p<0.02) depressed in active Crohn's disease (19.8 ± 7.3,n= 8) compared to either control subjects or patients with inactive disease (28.4 ± 6.3, n = 9). There was wide inter‐patient variability in ACE levels and hence the diagnostic value of random measurements of this enzyme in Crohn's di

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03580.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:The plasma concentrations of dopamine (DA), adrenaline (AD) and noradrenaline (NA) were measured during 29 routine hemodialysis (HD) treatments on 13 patients to determine whether any changes occurred in the concentrations of these substances during HD. All of the 13 patients studied demonstrated a fall in mean arterial pressure (MAP) when HD was commenced. Decreased concentrations of all three catecholamines were also demonstrated after the first hour of dialysis. Plasma AD rose after two hours, but NA and DA were still significantly lower than pre‐dialysis values at the end of HD. Study of 12 further patients during the first hour of HD confirmed that the NA level had fallen significantly by the fifteenth minute of HD, while the DA and AD levels took somewhat longer to fall. Both NA and DA were present in the dialysate in substantial amounts. Although the fall in MAP which accompanies HD is probably multifactorial, the loss of plasma catecholamines during HD may possibly contribute to the hemodynamic change

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03581.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:Coronary risk factors were compared in two groups of subjects aged 25–64 years. One group voluntarily, and at no cost, attended a risk factor screening clinic (n = 3844), while the second group represented a population sample drawn from the metropolitan Sydney electoral roll (n = 1394). Older subjects were over‐represented in the screening clinic compared with the electoral roll sample. Hypercholesterolemia was more prevalent in the screening clinic in older females, while hypertension and current cigarette smoking were less prevalent in the screening clinic in older subjects of both sexes. Obesity was less prevalent in the screening clinic in older males. A voluntary screening programme may generate a unique and possibly unreproducible population sam

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03582.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Abstract:Recently there has been an alarming increase in the number of schoolchildren sniffing glue (toluene). The medical complications seen in 18 boys, aged 14 to 18 years, include physical and mental dependence, pulmonary hypertension with cor pulmonale, restrictive lung defect, encephalopathy, peripheral neuropathy and high frequency, continuous discharges (neuromyotonia) on electromyogram.Glue sniffing took place in small groups and abusers sniffed directly from cans containing glue. Lower socio‐economic status, overcrowding, lack of attention by working parents, school failure and easy availability of the glue were commonly cited associated factor

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1984.tb03583.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY