摘要:

SummaryUnusual combinations—unexpected sets, excess or lack—of antigenic determinants, or Gm allotypes, on the constant regions of the heavy chains of the human IgG1 and IgG3 immunoglobulins are accounted for in terms of genetic events (exchanges, duplications and deletions) involving the DNA sequences, or exons, coding for the three CH1‐, CH2‐ and CH3 domains of the γ1 and γ3 chains. Equal and unequal cross‐overs at the level of the introns without damage to the CH exons are

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00777.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryWe investigated the capacity of anti‐I‐Akand anti‐I‐E/Ckmonoclonal antibodies (m.Ab.) to inhibit T lymphocyte proliferative responses to soluble antigen (Keyhole limpet hemocyanin), alloantigens (H‐2 or non‐H‐2 related) and a mitogen (Concanavalin A). Surprisingly, specific inhibition was observed in all circumstances, and with both anti‐I‐Akand anti‐I‐E/Ckm.Ab., whether the responses tested were I restricted in cell mixing experiments or not.The significance of the inhibition by anti‐Ia m.Ab. of non‐Ia‐restricted responses is still not completely understood. These results, however, strongly suggest thatin vitroinhibition by anti‐Ia antibodies of T cell proliferative responses does not necessarily indicate I restriction of the presentation to T lymphocytes

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00778.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummarySerum samples were collected from 113 healthy Caucasian volunteers before and after vaccination with meningococcal polysaccharides (MPS) group A and group C. Antibodies to MPS group A and group C were measured and sera were typed for several Gm and Km (1) allotypes. A significant association was found between the Gm 1,3,17; 5,13,14,21 phenotype and low immune responsiveness to MPS group A. These results suggest the possible existence of an immunoglobulin allotype‐linked immune suppression (Is) gene(s) in ma

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00779.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryA heterophile rheumatoid factor (RF) response to LPS was measured in mice by means of a plaque assay using target cells coated with bovine IgG. CBA mice were high responders and A, and DBA/2 were low responders, while strains C57B1, and LP/J showed low to intermediate responsiveness. Use of appropriate congenic strains confirmed that responsiveness is not closely associated with either H‐2 or Igh. Failure to respond is not likely to be due to a V‐region deficiency, nor can it be readily circumvented, by heterosis (complementation) or the use of high doses of LPS or an extra virulent form of LPS. Breeding experiments show a quantitative trait with maternal responder status having a measurably positive eff

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00780.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryThe T cell alloantigens A.R.T.‐1, A.R.T.‐2, Pta, Ag‐F and RT‐Ly‐2 were examined for linkage to albinism and the haemoglobin variant Hbb, and for cell expression similarities in the rat. The A.R.T.‐1 alloantigen was not linked to either A.R.T.‐2, albinism or Hbb. The A.R.T.‐2 alloantigen was demonstrated to be closely associated to albinism and Hbb with a recombination frequency of approximately 3% with albinism and 1% with Hbb. The four recombinants (out of 104 animals examined) were subsequently analysed with alloantisera to Ag‐F, Pta and RT‐Ly‐2. These alloantisera detected an antigenic system(s) which appeared to co‐segregate with A.R.T.‐2 in the recombinants studied Characterization of the specific T cell populations expressing each alloantigen demonstrated that removal of the cells bearing any one of the alloantigens removed all the cells expressing any of the other alloantigens. These results demonstrate that the four alloantigenic systems A.R.T.‐2, Pta, Ag‐F and RT‐Ly‐2 are located in the same genetic region of linkage group I, and appear to be expressed on the same peripheral T

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00781.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryHuman erythrocytes expressing the rare blood group MNSs‐related antigen Sta(Stones) have an abnormal hybrid sialoglycoprotein designated (δ‐α)Sta. The abnormal (δ‐α)Stasialoglycoprotein probably results from chromosomal misalignment with unequal crossing over between the α and δ genes in a manner analogous to that which gives rise to the anti‐Lepore‐ty

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00782.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryA monoclonal antibody, H8, was produced which binds to a red cell antigen of very high frequency absent only from the red cells of JMH negative individuals. Serologically H8 reacts like human anti‐JM

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00783.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

SummaryJ. L. GLICK; Fundamentals of Human Lymphoid Cell Culture

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1982.tb00784.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY