摘要:

SUMMARYSix individuals with an established recombination between the HLA‐A and the HLA‐B loci of the major histocompatibility complex have been tested in unilateral mixed lymphocyte cultures with other members of their families. A weak, but statistically significant lymphocyte activating influence of the HLA‐A chromosomal region has been obs

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00608.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe human allogeneic serum RM3 recognizes a lymphocyte structure inherited with the HLA chromosome. Population studies show several positive associations with antigens of the HLA‐A and HLA‐B series. Negative associations have been found with antigens of the HLA‐C series. Moreover the distribution of the RM3 factor is in Hardy‐Weinberg equilibrium with that of the HLA‐C alleles.However, serological investigations (namely the ‘lysostrip’ technique) bring evidence that RM3 serum does not appear to contain antibodies directed against any of the known antigens of the HLA‐A, B and C series. The study of a segregant family, showing a crossing over between the HLA‐A and HLA‐B loci, shows that the RM3 factor segregates on the side of the HLA‐A locus. In conclusion, within the limits of the serological approach used, the present study presents evidence of a new serologically defined HLA locus, different from t

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00609.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYSeven mouse tumour cell lines of different aetiology and origin were tested for the expression of surface alloantigens using twenty‐four well defined H‐2 allo‐antisera and anti‐Thy 1.2. We used a new radioassay that involves antibody‐complement treatment of the tumour target cells followed by postlabelling the surviving tumour cells with14C‐thymidine. With a relatively high frequency the anti‐H‐2 sera were reacting differently with the tumour cells than with respective tive syngeneic lymphoid cells. Thirty‐six anomalous reactions out of 129 investigated were detected. Absorbtion experiments performed with H‐2 antigen positive or negative lymphoid cells revealed a striking similarity between these extra‐specificities and H‐2 specificities of foreign haplotypes. The results are discussed in relation to the biological importance of the extra‐specificities, both with regard to origin (derepression) and function (transplant

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00610.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe molecular relationship between H‐2 antigens and mammary leukaemia (ML) antigen at the surface of leukaemic L‐1210/v cells was studied by the ‘lyso‐strip’ method. Molecules carrying the private specificities of the H‐2dhaplotype are independent entities in the membrane of the L‐1210/v leukaemic cells and are not linked to molecules carrying the

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00611.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYCytolytic T lymphocytes (CTL) from murine sarcoma virus (MSV) or Friend leukaemia virus (FLV) inoculated mice lyse syngeneic much more efficiently than allogeneic FMRGi+ lymphoma cells. By comparing the cytolysis of various H‐2 different51Cr lymphomas by CTL from several inbred and congenic lines differing at H‐2, and by competition experiments using unlabelled cells, one can demonstrate that this phenomenon is due to an H‐2 barrier. H‐2b/H‐2dhybrid‐anti‐MSV‐CTL immunized by H‐2b, H‐2dor H‐2b/H‐2dtumours lyse only FMRGi+ lymphomas of the same H‐2, and their activity for a given target is inhibited only by H‐2‐identical competitive cells. H‐2 antigens are therefore directly involved in the interaction between tumour cells and immune CTL which probably react with an 'H‐2 modified' antigen of the tumour cells surface. The use of CTL from intra‐H‐2 recombinant lines shows that H‐2D and probably H‐2K molecules are involved, but vary according to the tumour cells. A possible role of the I region is discussed as well as the implications of these results in i

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00612.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe presence of H‐2D and K antigens on mouse spermatozoa has been investigated by absorption followed by testing on the proper target lymphocytes. It is concluded that, in addition to Ia antigens, H‐2D and K antigens are indeed expressed on mouse sperm ce

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00613.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYRabbit anti‐rat xenoantisera were raised by intravenous injection of splenic lymphocytes. After absorption with the appropriate rat red blood cells for removal of ‘species‐specific’ antibodies, many agglutinating specificities remained which were quite similar to the corresponding alloantisera with the exception of the Ag‐B5 haplotype. In attempts to produce specific Ag‐B xenoantisera, two groups of histocompatibility antigens were discovered: one consisting of Ag‐B1, Ag‐B3, Ag‐B4, Ag‐B7 and Ag‐B8 to which specific Ag‐B antisera could be produced, and another comprised of Ag‐B2, Ag‐B5 and Ag‐B6 to which specific Ag‐B antisera could not be made by any of several methods. Xenoantisera produced by a rapid hyperimmunization technique and all alloantisera tested were cytotoxic, whereas no cytotoxic antibodies could be detected in the xenoantisera produced by

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00614.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SUMMARYThe possible involvement of a suppressor cell mechanism in neonatally induced allograft tolerance was tested in two different mouse‐strain combinations. In an H‐2 incompatible donor‐recipient combination presented by the congeneic strains B10.D2 and B10.D2(M504), adoptive transfer of tolerance with 5 × 107spleen cells to syngeneic sublethally (400 R) irradiated recipients was successful resulting in a markedly prolonged test graft survival or even take. The result of tests for negative tolerance (which should be susceptible to abolition by means of cells from normally reactive donors) did not indicate that neonatally induced tolerance across the given barrier rested on this principle. The suppressor mechanism seemed to be involved in neonatally induced allograft tolerance also in the other strain combination (B10

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00615.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The Antigens, Volume II. Edited by M. SelaMethods in Cancer Research, Volume 10. Edited by H. BuschCell Membrane Receptors for Viruses, Antigens and Antibodies, Polypeptide Hormones, and Small Molecules.Ninth Miles International Symposium, Edited by R. F. BeersJr. and E. G. BassettLymphocyte Stimulation.By N. R. Lingand J. E. KayCyclic AMP, Cell Growth, and the Immune Response.Edited by W. Braun, L. M. Lichtensteinand Ch. W. ParkerHistocompatibility.By G. D. Snell, J. Daussetand S. NathensonThe Immune System. Genes, Receptors, Signals.Edited by E. E. Sercarz, A. R. Williamsonand C. F. FoxThe Biology of Human Fetal Growth.Edited by D. F. Robertsand A. M. Thomson

ISSN:1744-3121    

DOI:10.1111/j.1744-313X.1977.tb00616.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY