摘要:

A method is described for the synthesis of (1-acetylaminobenzene-4-sulphonamido)-2-thiophene and of (1-aminobenzene-4-sulphonamido)-2-thiophene, also called 2-sulphanilamido-thiophene. The acute toxicity of the above compounds has been determined and an evaluation made of their chemotherapeutic activity in experimental infections of white mice with Pneumococcus Type I; 2-sulphanilamido-thiophene shows no chemotherapeutic activity.

ISSN:1923-4287    

DOI:10.1139/cjr41b-033

出版商:NRC Research Press    

年代:1941

数据来源: NRC

摘要:

The dihydrochloride and sesquipicrate salts of 4-(or 5-)aminoglyoxaline have been prepared in the pure state for the first time. Previous attempts to isolate the substance have failed largely because insufficient allowance was made for the instability of the substance in aqueous media. The new glyoxaline is highly reactive and has unusual properties for a glyoxaline. It has certain properties like those of 4-(or 5-)guanidinoglyoxaline, being here proved to be a hydrolysis product of guanine.

ISSN:1923-4287    

DOI:10.1139/cjr41b-034

出版商:NRC Research Press    

年代:1941

数据来源: NRC

摘要:

Among the products of reduction of 4-(or 5-)nitroglyoxaline, formation of a blue pigment has been observed by various workers. The authors regard this pigment as a diglyoxalone containing the characteristic indigoid group, —CO∙C=C∙CO—. Its formation is dependent on the existence of 4-(or 5-) hydroxyglyoxaline, formed by deamination of the corresponding amino- compound. The hydroxyglyoxaline readily tautomerizes to the glyoxalone, which on oxidation condenses to form the pigment in quest

ISSN:1923-4287    

DOI:10.1139/cjr41b-035

出版商:NRC Research Press    

年代:1941

数据来源: NRC

摘要:

A method is described for the estimation of urinary glyoxalines that has certain advantages over the Koessler and Hanke method, though based on the same principles of urinary fractionation by basic lead acetate and employing the Koessler and Hanke diazo reagent. It is found that normal individuals commonly excrete 200 mg. of urinary glyoxalines, though some excrete less than half this amount, and others two or three times this amount in the course of 24 hr. Urine glyoxalines are thought to be largely of endogenous metabolic origin.

ISSN:1923-4287    

DOI:10.1139/cjr41b-036

出版商:NRC Research Press    

年代:1941

数据来源: NRC

摘要:

It has been found that recent modifications of the Skraup quinoline synthesis can be further improved as to yield and ease of operation by substituting acetylated amines for the free bases.

ISSN:1923-4287    

DOI:10.1139/cjr41b-037

出版商:NRC Research Press    

年代:1941

数据来源: NRC