摘要:

Abstract.The persistence of hepatitis B surface antigen (HBsAg), e antigen (HBeAg) and antibodies to e antigen (anti‐HBe) was studied retrospectively in 197 Finnish voluntary blood donors, who had been found positive for HBsAg by routine screening in 1970 or 1971. Two samples were available from each donor: the first was taken in 1970 or 1971 and the second in 1978; the average interval between the specimens was 7.6 years. All except one (99.5%) of the donors remained HBsAg carriers during the whole study period. HBeAg was detected initially in 3 (2%) cases, all of whom lost HBeAg after the follow‐up, and 2 converted to anti‐HBe‐positive. Anti‐HBe was found in the first samples of 158 (80%) HBsAg carriers, 154 (97%) of whom were still positive for anti‐HBe in the second samples. These results suggest that the HBsAg carrier stage is stable as for the presence of HBsAg a

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02322.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.A method is described using double diffusion with a perspex template for determining tetanus antitoxin levels in the plasma of volunteers who have been hyperimmunized with tetanus toxoid for the purpose of producing human tetanus immune globulin. This test is simple to perform, economical, sentitive, reproducible and is in excellent agreement with the standard toxin neutralization test in mice. Comparisons with thein vivotoxin neutralization test are presented for this test, the passive hemagglutination, radial immunodiffusion and counter electrophoresis methods.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02323.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.Remarkably high titers (80–160) of quinidine‐specific antibodies were detected in the serum of 5 patients with suspected quinidine purpura, when126I‐labeled staphylococcal protein A was used as the marker of IgG bound onto platelets. During a follow‐up of 3 of the patients, the antibody titers declined.The antibodies could be detected even when the final drug concentration was reduced from 0.3 to 0.003 mmol/I (i.e. therapeutic levels). The reaction between serum and platelets was independent of the type of quinidine salt used. No cross‐reactivity occurred with quinine.Heat inactivation of the serum did not decrease the quantity of specific antibodies detected on the platelets. The sedimentation behavior of antiplatelet activity in density gradient centri‐fugation resembled that of 7 S antibodies. When sedimentation was, however, effected on the drug‐serum mixture, the reactivity of

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02324.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.10,853 sera, collected from ‘healthy’ blood donors during the period December 1977 to May 1979, were tested for the presence of penicillinase‐sensitive penicillins by a bio‐assay technique usingBacillus subtilisATCC 6633 as test organism. Their presence could be demonstrated in 30 sera (0.27%), at concentrations equivalent to 0.2–4.0 μg/ml of penicillin G.The implications of these findings are discussed, particularly the possibility of their relationship to nonhemolytic adverse reactions to t

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02325.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.To determine whether tetanus toxoid given during pregnancy increases the risk of haemolytic disease of the new‐born, 818 group 0 pregnant women were given one to three doses of tetanus toxoid during the third trimester. There was a significant increase in the incidence of neonatal jaundice among the ABO‐incompatible infants of women given toxoid, compared to a control group. Comparative studies were also done at two hospitals: tetanus toxoid was not given during pregnancy at one hospital and was used routinely at the other. More of the mothers given toxoid had high titres of igG anti‐A or anti‐B and more of their ABO‐incompatible infants became jaundiced. Thus these studies suggest an increased risk of haemolytic disease of the new‐born due to ABO incompatibility when tetanus toxoid injections are given durin

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02326.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.12 regular blood donors were selected on the basis of subnormal serum ferritin levels as a criterion for iron deficiency. It was found that all had high transferrin levels but only 5 had subnormal serum iron or transferrin saturation. The donors were given oral iron therapy in a dose of 2,800 mg between each phlebotomy, and the donation interval was standardized to 8 weeks. Test samples were collected every 4th week. After an initial rise in ferritin during the first 2 months, 6 of the donors again had subnormal serum ferritin levels, and the iron dose was therefore doubled after 32 weeks. Following this, all subjects taking the higher dose had normal ferritin values and stainable marrow iron was found at the end of the study, after 92 weeks. 3 subjects did not take the higher dose, had no raised serum ferritin level or stainable hemosiderin. It is concluded that serum ferritin estimation can be used to monitor the therapy in blood donors so that a satisfactory amount of iron is stored.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02327.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Abstract.9 healthy subjects dosed with acid‐citrate‐dextrose, NIH formula B (ACD‐B) while undergoing plateletpheresis with the continuous‐flow IBM Model 2997 centrifuge, received on average 59.5 ± (SD) 3.2 mg Na3citrate‐kg‐1. h‐1. This rate of infusion of Na3citrate resulted in a maximum 12‐fold rise in the concentration of citrate in serum (plasma) following the processing of 10 litres of whole blood, and subsequently reduced the level of total calcium in serum (plasma) by 9%. This dose of Na3citrate produced no clinical symptoms suggestive of hypocalcaemia in these subjects, even though the use of acid‐citrate‐dextrose, NIH formula A (ACD‐A) under identical conditions has been reported to reduce significantly the level of total calcium in serum, and concomitantly increase the number or reactions occurring in donors. From previous studies employing the intermittent‐flow centrifugation system of plateletpheresis, a rate of infusion of Na3citrate below 65 mg.kg‐1. h‐1can insure maximum donor safety and this rate can be achieved with the IBM Model 2997

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02328.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02329.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02330.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1980.tb02331.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY