摘要:

Abstract.A family is presented, in which the mother developed strong neutrophil granulocyte‐specific antibodies with the specificity anti‐NA1. The first and third children, both NA1‐positive, suffered from severe transient neonatal neutropenia, but the second child, NA1‐negative, did not.Anti‐NA1antibodies were detectable in the serum of one affected child and the antibody level was directly related to the extent of neutropenia. The incidence of granulocyte‐specific antibodies in 198 pregnant women was determined and foun

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04390.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.A 12‐month‐old child neutropenic since the age of 8 months, was referred to our institute for a sepsis fromCandida albicans.On exploring the cause of neutropenia, an anti‐NA1antibody could be detected in the patient's serum. This antibody seemed to be responsible for the neutropenia because the child's PMN type was NA1+. The reactivity of the autoantibody with the patient's own granulocytes was confirmed by direct and indirect immunofluorescence studies performed on blood and marrow cells. A reduced number of T lymphocytes with poor PHA responsivity has been interpreted as the possible cause of the autoimmune disease. Steroid therapy did not cure the neutropenia but the child's general condition imp

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04391.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.We describe 29 children with auto‐immune haemolytic anaemia (AIHA). The patients could be followed up for long periods of time. The auto‐antibodies, responsible for the AIHA, are described as well as the associated diseases that could be diagnosed, the clinical course and some clinical aspects of special importance. Finally, the treatment given to these patients and its results are discus

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04392.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.In the years 1975–1976, 6, 766 unselected (ABO compatible and incompatible) primigravidae parturients with uncomplicated delivery were given 100 μg (250 IU) anti‐D IgG. A total of 4,473 presented for the 6‐month control examination. IAGT was positive in 5 cases (0.11%). The 200 μg (500 IU) dose was administered to 1,543 women. Of these, 962 presented for serological control. IAGT was positive in 1 case (0.10%). The difference is not significant. The findings support the results of previous studies suggesting that 100 μg anti‐D is a sufficient dose to prevent immunization in uncomplicated

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04393.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Using ultracentrifugation, gel filtration, and ion exchange, an attempt was made to completely separate immunoglobulin IgM and IgG present in pooled human serum of blood group O. The quality of separation was studied by testing IgG fractions for the presence of IgM by a sensitive detection method. It is demonstrated by rheophoresis that small amounts of IgM always remain detectable in the IgG fraction. This is of clinical importance because conclusions on the presence of specific antibody of different Ig classes are usually drawn under the assumption of complete separation. The control of the efficacy of the separation process using a sensitive detection method for Ig of different classes is recommended.

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04394.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.Four Kp(a‐b‐) Japanese sisters, the product of a consanguineous mating, have otherwise normal Kell antigens.Kpc, a ‘new’ allele ofKpaandKpbis the most probable bac

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04395.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.The antigen corresponding to the ‘new’ alleleKpcpostulated in a Japanese family is the low frequency antigen Levay recognized in England 33 years

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04396.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Abstract.When blood samples from 5,864 healthy Indian blood donors were tested with anti‐I, seven samples failed to react or reacted only weakly. Further studies with a number of anti‐I and anti‐i sera suggested that these samples had the phenotype I‐i‐ and reacted weakly with anti‐IT. In one family, the I‐i‐ phenotype was present in th

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04397.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04398.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0042-9007    

DOI:10.1111/j.1423-0410.1979.tb04399.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY