ISSN:0250-8095    

DOI:10.1159/000167205

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Fourteen reports have identified an association between lower dietary calcium consumption and higher blood pressure in adults. The relationship between dietary calcium and blood pressure status of humans may be modified by a wide variety of demographic, environmental, life-style, and nutritional factors. Reduced dietary calcium intake may be a proximate cause of several of the reported biochemical abnormalities of Ca2+ metabolism including the reductions in serum ionized Ca2+ concentrations and increases in circulating parathyroid hormone levels. The paradoxical increases in intracellular free Ca2+ observed in hypertension on low dietary Ca2+ intake suggest that a primary defect in the cellular handling of Ca2+ may exist, possible mediated through defective Ca2+ adenosine triphosphatase pump activity.

ISSN:0250-8095    

DOI:10.1159/000167206

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

The effect of different dialyzer membrane materials (cuprophan, cellulose hydrate, polyacrylonitrile, polymethylmethacrylate, ethylene-vinyl alcohol copolymer) on the ultrafiltrate proteinase activity was investigated in 26 patients with acute renal failure (ARF) and 40 patients undergoing regular hemodialysis treatment (RDT). Furthermore, the proteinase activity was characterized in vitro using azocasein and phosphorylase kinase as substrates in the absence and presence of different proteinase inhibitors. Proteinase activity of ultrafiltrates obtained from ARF patients was significantly enhanced with the dialyzer KF 101 (ethylene-vinyl alcohol copolymer). The digestion pattern of phosphorylase kinase revealed an identical type of proteinases in ultrafiltrates of ARF and RDT patients. The pH optimum of this proteinase was at alkaline pH. The proteinase activity could be inhibited in the presence of EDTA, whereas serine proteinase inhibitors were ineffective. Furthermore, the inactivated proteinase after Sephadex G-10 chromatography (in order to separate ultrafiltrate electrolytes and trace elements from protein) could be reactivated after the addition of Mg++ and/or Ca++. We conclude that a metalloproteinase can be found in ARF and RDT patients, and that KF 101 is more effectively eliminating the proteinase activity in ARF patients than other dialyzer membranes.

ISSN:0250-8095    

DOI:10.1159/000167046

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000167208

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000167209

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000167210

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000167211

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Sarcoid granulomatous nephritis was observed in 2 patients. Renal failure was present in both patients in the absence of hypercalcemia or nephrocalcinosis. Specific tubular dysfunction manifested as an acquired Fanconi syndrome in 1 patient. Steroid therapy was effective in causing regression of the renal granuloma, but there were significant interstitial changes on repeat renal biopsy which were accompanied by persistent tubular dysfunction. Sarcoid granulomatous nephritis may be a not infrequent cause of renal dysfunction in sarcoidosis.

ISSN:0250-8095    

DOI:10.1159/000167048

出版商:S. Karger AG    

年代:1986

数据来源: Karger

摘要:

Seventeen children with IgA nephropathy were grouped according to the absence (group I, n = 10) or presence (group II, n = 7) of glomerular basement membrane (GBM) deposition of IgA to determine whether GBM deposition of IgA correlated with laboratory or pathologic data at diagnosis or clinical status at follow-up. Children in group II had significantly (p < 0.01) more proteinuria at diagnosis than children in group I. The percentage of glomeruli demonstrating crescent formation was significantly (p < 0.05) higher in group II biopsies. Chronic changes of fibrous crescents, segmental sclerosis, global obsolescence, tubular atrophy, and interstitial fibrosis were also significantly (p < 0.001) more common in group II biopsies. After a mean follow-up period of 2 years, all children in group II have persistent proteinuria of more than 1 g/24 h, and 3 of 5 have renal insufficiency (2 require dialysis). In contrast, 2 of 9 group I children have proteinuria exceeding 1 g/24 h, and only 1 has renal insufficiency. We conclude that, as compared to children with IgA localized to the mesangium, children with IgA nephropathy and GBM deposition of IgA have a higher urinary protein excretion at the time of diagnosis, more severe histologic alterations including a greater percentage of glomeruli demonstrating crescent formation, more chronic changes of segmental or global sclerosis, tubular atrophy, and interstitial fibrosis. Such children usually have persistent proteinuria and are more likely to develop progressive renal disease.

ISSN:0250-8095    

DOI:10.1159/000167049

出版商:S. Karger AG    

年代:1986

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000167212

出版商:S. Karger AG    

年代:1986

数据来源: Karger