ISSN:0250-8095    

DOI:10.1159/000167546

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.

ISSN:0250-8095    

DOI:10.1159/000167547

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A study on immunofluorescence of sialic acids in glomeruli from patients with diabetic nephropathy is described. Measurement of sialic acid in sera from 25 patients with diabetes mellitus was also performed. Renal biopsy specimens from 12 patients with diabetic nephropathy were stained with FITC-labeled antihuman IgG antiserum and rhodamine-labeled Triticum vulgaris (WGA) or Limulus polyphemus (LPA). These specimens were also stained with such reagents after treatment with neuraminidase, trypsin or citrate buffer. Both deposition of IgG and binding of WGA in the glomerular capillary walls were observed in all patients with diabetic nephropaty. The binding of WGA in the glomerular capillary walls in diabetic nephropathy was significantly increased compared with that in four normal renal tissues. However, the binding of LPA was hardly observed in the glomerular capillary walls of patients with diabetic nephropathy. The binding of WGA in the glomeruli was markedly decreased after treatment with neuraminidase although it was hardly decreased after treatment with trypsin or citrate buffer. The levels of sialic acid in sera from patients with diabetic nephropathy were markedly increased. It is suggested that accumulated substances in the glomerular capillary walls with an affinity for WGA are mainly composed of N-acetyl glucosamine and/or N-acetyl neuraminic acid in patients with diabetic nephropathy.

ISSN:0250-8095    

DOI:10.1159/000167548

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Cytodiagnostic urinalysis was tested to determine its utility in the evaluation of allograft dysfunction in renal transplant patients. Specimens were prepared using the Papanicolaou stain on cytocentrifuge preparations of standardized quantities of urine. Differential counts of blood cells (neutrophils, lymphocytes, red cells), renal tubule cells (convoluted, collecting duct, necrotic), and casts (i.e. hemoglobin, renal tubule cell) were included in the sediment evaluation. Receiver operating characteristic curves demonstrated collecting duct cell exfoliation at 20 per 10 hpf to be a more sensitive and specific reflector of acute rejection than lymphocytes at their optimum decision point of 13 per 10 hpf. Sixty-four percent of cytodiagnostic urinalysis diagnoses preceded the clinical diagnoses. Ciclosporin nephrotoxicity was differentiated by the exfoliation of renal tubule convoluted cells in excess of collecting duct cells. The advantages of this technique over membrane-filter or phase-microscopic techniques for examining urine sediment of both transplant and nephrology patients include improved sensitivity and specificity in identification of sediment elements and reliable quantitative data for use in detecting renal disease and for monitoring therapy.

ISSN:0250-8095    

DOI:10.1159/000167549

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

We assessed the effect of acyclovir therapy on renal function during a course of therapy for herpesvirus disease. Renal function was assessed by measuring the clearances of inulin, albumin, and β2-microglobulin at the beginning and end of acyclovir therapy. Thirty-two patients had valid paired inulin clearances and 21 had valid paired albumin and (32-microglobulin clearances. No significant mean decrement of renal function was observed; however, 2 patients had a reversible renal dysfunction associated with acyclovir therapy which disappeared soon after discontinuation of the drug and was unassociated with a prior or recurrent renal dysfunction in short-term follow-up

ISSN:0250-8095    

DOI:10.1159/000167550

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The survival experience of 213 patients with end-stage renal disease treated over a 10-year period in a community hospital dialysis center is the focus of the study. Statistical assessments of the effects of risk factors and alternative treatment modalities on patient survival are made using survival functions and proportional hazards regression models. Comparisons of the data base and the main results with those of previous published reports are presented. A key result is our finding of improved survival since the introduction of a continuous ambulatory peritoneal dialysis program in 1980. This result is discussed in some detail.

ISSN:0250-8095    

DOI:10.1159/000167551

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:0250-8095    

DOI:10.1159/000167552

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The mechanism by which keto-acid-supplemented diets may retard the progression of renal failure is not known. We examined whether the protective effect of keto acids may be independent of a low nitrogen intake. Azotemic sub totally nephrectomized Sprague-Dawley rats were pair-fed a 30% casein diet supplemented with a 10% keto acid mixture (n = 10) or 10% cornstarch (n = 10) for 18 weeks. No differences were observed between the two groups of rats with regard to survival, weight gain, plasma urea, blood pressure, albuminuria, or, at the termination of the study, PAH and inulin clearances. Creatinine clearances, measured weekly during the study, were transiently higher in the keto acid group. There was no difference in the incidence or severity of segmental glomerulosclerosis or tubular atrophy in the two groups. These results indicate that the keto acid mixture used did not exert a protective effect against glomerular sclerosis and progressive albuminuria in azotemic rats fed high-protein diets.

ISSN:0250-8095    

DOI:10.1159/000167553

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Different hormonal parameters are studied in a pregnant woman with chronic renal failure undergoing hemodialysis. Serum concentrations of human chorionic gonadotropin, progesterone, 17-hydroxyprogesterone, α-fetoprotein, human placental lactogen were all higher than the normal range. This is probably related to a decreased metabolic clearance rate of these hormones. Dehydroepiandrosterone sulfate (DHEAS), which is low before pregnancy and during the first week of gestation, tends to increase later. Serum estradiol is lower than the normal range. This decrease probably results from the low concentration of DHEAS available to placental aromatization. Finally, pregnancy-specific β1-glycoprotein concentration follows the normal range and may be considered as the most reliable parameters to evaluate the fetoplacental well-being in these high-risk pregnancie

ISSN:0250-8095    

DOI:10.1159/000167554

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The definitive diagnosis of renal vein thrombosis (RVT) depends upon the demonstration of a persistent filling defect or defects within the renal vein by renal venography or selective renal angiography during the venous phase. We describe here the utilization of digital subtraction venography to diagnose RVT in a young nephrotic male patient. We injected 40 cm3 of contrast substance in a foot vein, having 4-second delayed films over the inferior vena cava and renal veins. We demonstrated a retrograde propagation of the dye into the right renal vein indicating intrarenal venous thrombosis. ‘Renal vein thrombosis and digital venography

ISSN:0250-8095    

DOI:10.1159/000167555

出版商:S. Karger AG    

年代:1988

数据来源: Karger