ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Six children (1 month to 5 years old) with DIC were treated with bolus injection of AT-III concentrates and/ or continuous heparin infusion. In one case, when AT-III concentrates were administered without heparin, the platelet count was normalized in accordance with a rise in the plasma AT-III level. In the other children, who were treated with both AT-III concentrates and heparin, most of the abnormalities in coagulation studies were normalized within 5 days in four of five cases. These findings suggest that the administration of AT-III concentrates may significantly enhance the therapeutic efficacy of heparin, and that the use of AT-III concentrates with heparin is a safe and effective regimen for the treatment of childhood DIC.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

A 12-year-old white female with recurrent Burkitt's lymphoma had a spontaneous remission associated with a localized herpes zoster infection. The remission lasted nearly 2 months before the tumor recurred in the central nerous system. LDH isoenzyme determinations done on an earlier ovarian tumor and serum at time of bone marrow relapse showed different predominant LDH isoenzyme patterns. These data might be interpreted as showing that different malignant cell clones were responsible for ovarian and bone marrow relapses. Studies to elucidate the mechanism of spontaneous remission at the time of zoster infection demonstrated serum factor(s) which stimulated normal B lymphocytes.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Truly disseminated adenovirus disease is rare and appears to be limited to patients with severe combined T and B cell deficiency. This report describes an 18-month-old child with malignant histiocytosis treated with chemotherapy who developed a fatal disseminated type 2 adenovirus infection. Histologic changes in the tissues of multiple organs as well as the presence of typical crystalline structures in sections of the liver seen with electron microscopy provided evidence of viral replication. Adenovirus was recovered from the involved organs and from daily serum samples obtained over a 2-week period prior to death. The possibility that the child may have had virus associated histiocytic disease prior to chemotherapy is discussed.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The cytologic evaluation of a case of acute leukemia proceeds in two stages: 1) assigning the leukemia to one of two major classes, acute lymphocytic leukemia (ALL) or acute nonlymphocytic leukemia (ANLL); and 2) determining the proper subclassification of ALL or ANLL to which the case belongs.Although features such as nuclear morphology, number and nature of nucleoli, and nuclear/cytoplasmic ratio are useful criteria, the major morphologic features which distinguish ANLL cells from ALL cells are the presence of azurophilic granules and/or inclusions derived from fusion of these granules (Auer bodies). In most instances these can be visualized in the conventional blood film or bone marrow preparation. Sometimes, however, granules and Auer bodies are too small or too few to be seen with the light microscope. In such cases histochemical or ultrastructural studies will aid in proper classification.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Patients with disseminated neuroblastoma are considered a poor-risk category, hence, our approach towards their treatment should be reconsidered in terms of the-unique clinical and biological characteristics of neuroblastoma tumor growth. To this end, we have devised a treatment program consisting of surgery, and a schedule of sequentially escalating doses of cyclophosphamide combined with other drugs until a minimal disease status is obtained. When this is achieved, the patient is treated with maximal therapy, i.e., total body irradiation, high-dose L-phenylalanine mustard and dianhydrogalactitol followed by reconstitution with an autologous bone marrow graft. Details of this program include problems associated with evaluation of response, i.e., evaluation of risk, determination of minimal tumor burden, avoidance of toxicity, and compensation for supportive measures during maximal therapy. Additional problems of purging bone marrow of tumor cells are considered.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

The use of chronic transfusions in patients with sickle cell disease is now the common practice after a stroke has occurred, in order to prevent the highly probable fecurrence. Clinical studies show that chronic transfusion prevents the recurrence of a stroke.Review of the natural history of sickle cell disease indicates, however, that the mortality and morbidity associated with hemoglobin SS disease are quite high. Use of chronic transfusion, given before the occurrence of stroke and other irreversible organ damage, can be considered as an alternative to the conservative management of sickle cell disease. Chronic transfusion has become practicable since the recent advances in chelation therapy have essentially eliminated the risk of secondary iron overload.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

In conducting collaborative cancer therapy trials, investigators have an obligation to answer relevant and realistic research questions, while providing the patient with quality treatment. They should participate only in well-conceived, well-designed protocols. Their patients should follow the protocol as closely as possible. Protocol violations are admissible only in extreme cases, instances in which the patient's well-being is clearly best served by this violation. The participating clinicians have the obligation to submit quality and timely data. Finally, the results of each study must be written up in such a fashion that the reader has a clear understanding of the goals and outcomes of the trial.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID

摘要:

Quality collaborative clinical trials cannot be run without the complete commitment of every investigator. The clinician must provide quality data and must submit the data on time. The statistical office and protocol coordinator are responsible for maintaining confidentiality and for keeping a watchful eye on the overall conduct of the study. Safety monitoring of experimental drugs or drug combinations is a central responsibility, since individual investigators generally only see the statistical reports on the study, rather than the raw data. It is critical that interim statistical reports be interpreted correctly so as not to affect accrual adversely.A separate issue discussed in this article is the answering of negative questions. Can therapy be reduced and still obtain equal efficacy? Such studies are based on sound ethical considerations, but they are hazardous since they could lead to serious worsening in cure rates.

ISSN:0192-8562    

出版商:OVID    

年代:1985

数据来源: OVID