摘要:

Tumor-directed immunity was assessed in 29 patients with neuroblastoma (NB). Cell-mediated and humoral immunity were assessed in vitro using the one-stage direct capillary leukocyte migration inhibition test and the indirect, membrane immunofluorescence test, respectively. Leukocytes from 83% of NB patients, 40% of normal children, and 24% of adults were inhibited by NB-derived materials. NB patients' leukocytes reacted as frequently with materials from allogeneic neuroblastomas as with autologous extracts. Sera from 50% of N B patients, 8% of child controls, and 18% of adult controls reacted with allogeneic tissue cultured neuroblastoma cells.Leukocytes from NB patients, control children, and control adults were inhibited at a similar low frequency by extracts of human melanomas and cancers of cervix, colon, and breast. Sera from NB patients and controls reacted infrequently with cultured melanoma cells.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Bone involvement in Hodgkin's disease usually occurs late in the course of the illness, together with extensive nodal involvement. In the past 5 years, we have seen four adolescents with Hodgkin's disease who presented with primary bone lesions. All had disseminated lymphoid involvement when the final diagnosis was made 3–11 months later. A review of the literature showed 13 more cases of similar presentation. The patient characteristics are discussed and the diagnostic difficulties are emphasized. Hodgkin's disease should be considered in the differential diagnosis of primary osseous malignancies.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Vaccine reaction data were obtained from 154 patients with sickle cell disease immunized with tetradecavalent pneumococcal polysaccharide vaccine. There was a high rate (70%) of mild reactions, primarily at the site of injection. Fever over 100°F was uncommon and precipitation of symptoms similar to sickling crisis was rare. Development of local reactions was associated with the level of preimmunization pneumococcal antibody titer.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

One-hundred seventy-four children with sickle cell disease (SCD) were immunized with a single dose of tetradecavalent pneumococcal vaccine. Preimmunization and postimmunization antibody against 13 of the 14 pneumococcal capsular antigens was measured by indirect hemagglutination (IHA). The ability of each antigen to stimulate antibody following immunization was characterized by one of three types of responses: (1) poor antibody response regardless of the age at immunization (capsular types 6A, 14, and 19F); (2) improving antibody response with advancing age at immunization (capsular types 1, 4. 9N, 12F, 18C, and 23F); and (3) good antibody response regardless of age at immunization (capsular types 2, 3, 7F, and 8). An increase in antibody following immunization was significantly correlated(p< 0.0005) with an increasing level of preimmunization antibody titer for all 13 antigens. Through the first 24 months of study, two episodes of pneumococcal sepsis caused by group 23 pneumococci were documented in two children immunized prior to 24 months of age (incidence rate, 4.40/100 patient-years in children less than 5 years of age), and one additional episode caused by a group 23 pneumococcus occurred in a 57/12-year-old child (incidence rate, 0.66/100 patient-years in children greater than 5 years of age).These observations suggest that anamnestic immune response significantly contributed to the enhanced antibody response observed in older children and adults. Only modest vaccine efficacy may be expected among children with SCD who receive a single dose of pneumococcal vaccine.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

This case represents leukemia and retinoblastoma in two separate children of a patient with retinoblastoma. This occurrence of retinoblastoma and acute lymphoblastic leukemia in the same sibship is uncommon and emphasizes multiple occurrence of some tumors.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Bone marrow transplantation has become an accepted mode of treatment for children with acute myelocytic leukemia in their first remission and acute lymphocytic leukemia after their first bone marrow relapse. Two-year survival rates of 50% can be achieved in patients undergoing transplant during remission, in contrast to a 2-year survival of 15% in those undergoing transplant while still in marrow relapse. Recurrence of bone marrow leukemia relapse is a significant cause of marrow transplant failure. Overt or occult testicular relapse occurs in 10–15% of males with acute lymphocytic leukemia receiving or having completed standard therapy regimens for control of their disease and frequently leads to a subsequent bone marrow relapse. This paper describes a child with acute lymphocytic leukemia who received a successful marrow transplant following bone marrow relapse and developed testicular leukemia relapse approximately 20 months after transplant. The experience with this child suggests that bilateral testicular biopsies should be a mandatory part of the routine evaluation to screen for residual leukemia before bone marrow transplantation.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

The period of adolescence in the patient with sickle cell disease seems to be a period of relative calm, medically speaking. The current 5-year prospective Cooperative Study of the Clinical Course of Sickle Cell Disease should demonstrate the actual spectrum of disease in this age group. The recent literature documents the significant relationship between retardation of growth and sexual maturation in the child with sickle cell disease, an effect which seems independent of the severity of the disease.Several other major problems in the adolescent are discussed, including psychological disturbances, leg ulcers, aseptic necrosis, pulmonary disease, priapism, stroke, cholelithiasis, and birth control. A retrospective series of 76 cases of sickle cell disease is briefly presented and the complications occurring during the second decade of life are reviewed.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Sickle cell disease, a disease prevalent among the negroes all over the world, is discussed first from the historical point of view. Its geographical occurrence which is highest in the African subcontinent and lowest in the United States depends on the prevalence of malaria in the environment and intermarriage of races.The sociocultural background of Nigeria is discussed along with its existing health and educational problems. These are related to the profound clinical manifestation of sickle cell disease.Some pitfalls in the diagnosis and manifestation of sickle cell disease are mentioned. The problems to the use of certain drugs are highlighted. In solving some of the problems of sickle cell disease attention should be focused on continuous health education, establishing sickle cell clinics, and research aimed at improving the environment of patients in the underprivileged situations of the world where sickle cell disease poses problems.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID

摘要:

Early diagnosis of hemoglobin diseases means the identification of a molecular phenotype at a stage when there is opportunity to prevent, minimize, or more adequately adapt to an anticipated health burden. Such diagnosis is presently possible in early childhood, in the neonatal stage, and in the fetal stage. A benefit of early diagnosis at all of these stages is the provision of additional options to parents for making informed decisions regarding prevention or for coping with the anticipated hemoglobin disease.

ISSN:0192-8562    

出版商:OVID    

年代:1982

数据来源: OVID