摘要:

The investigation of cardiac function in 13 acromegalic patients is described. Electrocardiographic abnormalities and cardiomegaly were present in seven patients one of whom had hypertension. Severe impairment of cardiac function was present in only one patient. Plasma volume was commonly increased, particularly in those patients with cardiac abnormalities whose disease was of longer duration than those with normal hearts. Follow-up of the patients over four years indicated that heart disease does not progress rapidly in acromegaly even in the presence of continuing activity.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Increased vascular resistance has been considered the hemodynamic hallmark of hypertension since cardiac output has been reported as normal. This assumption was reinvestigated in 25 normotensive subjects and 117 untreated hypertensive patients whose complete evaluation, including renal arteriography, permitted classification of type of hypertension. When the entire hypertensive group by itself was compared with the normals, the traditional conclusion was corroborated; elevated arterial pressure was associated only with increased vascular resistance. However, hemodynamic findings differed significantly when each type of hypertension was studied separately. Thus, cardiac output was normal in pheochromocytoma, renal parenchymal disease, and primary aldosteronism, increased in renal arterial disease (p < .001) and labile hypertension (p < .05), and reduced or low normal (p < .05) in essential hypertension. When essential hypertensive patients were subdivided into those with and without cardiac enlargement, output was reduced (p < .02) in those with nonfailing cardiac enlargement; but all, whether having normal or enlarged hearts had lower output than patients with renal arterial disease (p < .001). Peripheral resistance was elevated in all patients except those with labile hypertension. Therefore, hypertension no longer should be considered a homogeneous disease ascribed only to increased vascular resistance; hemodynamics vary significantly depending upon type and stage of disease.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Free and total cholesterol levels in the serum of 53 rhesus monkeys were determined. Large variations were observed among animals. Large fluctuations were also found in repeated weekly assays of serum cholesterol in many individual animals when reported in the conventional manner, i.e. in mg/100 ml of serum. The latter fluctuations tended to disappear when values were recalculated as fractions of dry serum solids. This finding indicates that the variability observed was in most instances due not to altered sterol metabolism but rather to changes In the water content of serum. The average total cholesterol values were 136.7 mg/100 ml serum and 123.0 mg/10 g serum solids. For free cholesterol the values were 37.8 mg/100 ml and 34.2 mg/10 g, respectively. Distribution of data according to sex, weight, time of day, end season of the year showed insignificant diurnal fluctuations and only slight variations due to the other variables.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

The transfer of labeled albumin from plasma and ascitic fluid to thoracic duct lymph was investigated in seven patients with ascites and portal hypertension. Ascitic fluid albumin gained access to the thoracic duct lymph before it could be detected in the plasma. Plasma albumin appeared in thoracic duct lymph more rapidly than did ascitic fluid albumin. A significantly greater fraction of the thoracic duct albumin was derived from the plasma than from the ascites. It was concluded that while much of the ascitic fluid albumin leaves the peritoneum via the thoracic duct, it contributes far less to the albumin content of thoracic duct lymph than docs plasma.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

Between October, 1966 and April, 1967, 312 patients with a provisional diagnosis of pneumonia and 154 control patients without respiratory disease admitted to the Philadelphia General Hospital were studied for the purpose of determining whether or not viral infections preceded the onset of bacterial pneumonia. Of the 312 patients in the former group, only 193 were considered ultimately to have had pneumonia. Of these 193 infections, 106 were thought to have been caused by pneumococcus, 12 by Kl. pneumoniae, ten by other bacteria, and one by adenovirus type 3. In 65 patients, many of whom received treatment before hospitalization, a causal agent could not be assigned. Herpes simplex virus was isolated from 5% of cases of pneumonia and 1.4% of controls. Significant rises in antibody to influenza A and toMycoplasma pneumoniaewere detected, with one exception, only in patients with pneumonia and not in controls; but the differences were not significant statistically. Five of six patients with influenza A infection had bacterial pneumonia. The results fail to demonstrate a close association of the endemic respiratory viruses under study with bacterial pneumonia and indicate the need for development of additional virologic and serologic techniques.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

A clinical study in a Coronary Care Unit on the use of lidocaine as an antiarrhythmic drug in 150 patients is reported. One hundred and ten of these patients had suffered an acute myocardial infarction. Intravenous lidocaine has proved to be a relatively safe, effective anti-arrhythmic agent to suppress ventricular arrhythmias associated with an acute myocardial infarction. The use of a single intravenous injection of 1 to 2 mg/kg resulted in complete suppression of ventricular arrhythmias in 82%. Hypotension was uncommon. Central nervous system signs occurred in 7%. Premedication with a sedalive-anticonvulsant; such as phenobarbital or chlordiazepoxide, may prevent central nervous system toxicity. Ventricular arrhythmias accompanying heart failure or shock will sometimes respond to lidocaine, but treatment of hypotension and the correction of heart failure require primary attention.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

摘要:

The time relationships of aortic blood flow and other hemodynamic variables were measured prior to, during, and after myocardial infarction in the dog. A helical magnesium wire placed in the coronary artery produced gradual occlusion with infarction in approximately ten days. Serial measurements of hemodynamic data showed significant changes during the time of infarction with return to preinfarction levels within three days. The heart rate increased 87 and the mean blood pressure decreased 10% without significant arrhythmia during infarction. The aortic flow, velocity and mean acceleration of flow decreased 8, 16, and 23% respectively, while the pre-ejection period did not change significantly. These findings suggest that the hemodynamic changes during myocardial infarction are the result of altered myocardial function. The measurements of electrical and mechanical time relationships are sensitive indicators of cardiac performance in myocardial infarction.

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID

ISSN:0002-9629    

出版商:OVID    

年代:1969

数据来源: OVID