摘要:

SummaryThree patients in the same family with Addison's disease were reported. Six others in this family died of similar Addison's disease symptoms. These nine patients were all male. Therefore, genetically an X‐linked inheritance was most probable.Detailed endocrinological examinations on these three patients were performed. Especially we observed the changes of the renin‐angiotensin system in Addison's disease. The plasma renin activity levels in these patients were high and suppressed by the administration of sodium chloride, Cortisol, and 9α‐fluorohydrocortisone.The blood pressure and secretion of aldosterone were little influenced by the administration of angioten

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1971.tb02366.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SummaryIn the attempt to diagnose TSD, amniotic fluid was obtained by amniocentesis in a mother whose first child was TSD. Amniotic fluid and uncultured amniotic cells showed absence of hexosaminidase A. The fetus was diagnosed as TSD and the pregnancy was terminated through artificial abortion. Hexosaminidase A in the fetal brain and liver was deficient and an increase of ganglioside Gm2was observed in the brain of the affected fetus.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1971.tb02367.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SummaryIn the treatment of congenital biliary atresia care should be taken to prevent rickets resulting from the insufficient Ca absorption obstruction of the bile excretion and due to failure of vitamin D absorption. In fact, however, these cases are infrequently found. The present case had the obstruction of the bile excretion to intestine because the liver abscess and external biliary fistura had been formed after the operation of the congenital biliary atresia. As a result, the failure of vitamin D absorption and the ensuing obstruction of Ca absorption occurred to induce a rickets. This case shows we have to give such patients who suffer from incurable obstruction of the bile excretion not less than 400 I.U./day of vitamin D which is required as the appropriate dose. The authors were successfully able to demonstrate the obstruction of the Ca absorption when the rickets occurred, by means of the radioisotope technique, the improvement of the Ca absorption and an increase of the Ca retention subsequent upon the vitamin D therapy.The authors wish to express our gratitude to Professor Itsuo Gamo, to Dr. Tsunesuke Shimotsuji for his guidance and encouragement and Mr. Masakatsu Inokuma for radiological studies.

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1971.tb02368.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SummaryThe three suspected cases of HSV encephalitis who still survive were reported.Case 1, a 8 months old girl, and case 2 of 8 years 11 months old girl were diagnosed with basis of clinical findings and clinical course, serological demonstration of greater than four‐fold rises in complement fixing antibody and non‐CRN antibody, significant rise in CRN antibody (CRN/non‐CRN) and tests which could rule out other common viral originCase 3 was diagnosed by isolation of virus from C.S.F. obtained at intraventricular puncture and by a significant rise in antibody (CF antibody, non‐CRN and CRN an

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1971.tb02369.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

SummaryAn examination for the membrane oxidation as a cause of oxygen poisoning was carried out by using erythrocyte membrane. 1) The addition of erythrocytes obtained from healthy human adults to retinol, dissolved in ethanol, resulted in hemolysis. The hemolysis induced by retinol was inhibited by added α‐tocopheryl acetate to the suspensions. 2) The hemolysis was induced by oxygen bubbling to the erythrocyte suspensions. This hemolysis was also inhibited by α‐tocopheryl acetate, while it was accelerated by a previous treatment of the erythrocytes with retinol in a dose of which hemolysis did not occur. The oxygen‐induced hemolysis accelerated with retinol, was also inhibited by α‐tocopheryl acetate. 3) The treatment of the erythrocyte suspensions with H2O2was carried out in the manner as previously devised by Rose and György, in which the erythrocytes used in this experiment resulted in no hemolysis. When previously treated the erythrocytes with retinol, in a dose of which hemolysis does not occur, hemolysis was induced by adding H2O2in the same manner, while it was inhibited by α‐tocopheryl acetate. When first treated with H2O2and subsequently with retinol, no remarkable hemolysis was observed in the erythrocy

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1971.tb02370.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1971.tb02371.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

ISSN:1328-8067    

DOI:10.1111/j.1442-200X.1971.tb02372.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY