ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01137.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01138.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Stapedectomy is known to give good results for otosclerosis. In this study, an audiometric evaluation of patients who underwent small‐opening stapedotomy has been carried out at an early stage (3 and 5 days after surgery), and 1 month after surgery.At day 5 almost 60% of the patients showed a good functional result (mean residual post‐op air conduction/pre‐op bone conduction gap within 5 dB).While the timing of 4 kHz recovery overlapped that of the lower frequencies, recovery for 8 kHz was evident only at day 30, and was less likely to occur than for

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01139.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Over the years many laboratory factors have been studied with a view to predicting the course of head and neck cancer. The lack of success prompted the application of various measures of cell kinetics to this topic. The present study includes 79 patients with a proven squamous cell carcinoma of the head and neck at various sites and having various treatments. Ki67 staining was carried out using the avidin‐biotin complex method and counts recorded per 1000 tumour cells. The patients' mean age was 61 years and the 5 year survival was 54% (95% CI, 29‐73%). The median Ki67 index was 278 representing the number of cells stained positively per 1000 tumour cells. The minimum staining was 82 and the maximum 808 with a lower quartile of 95 and an upper quartile of 452. The Ki67 index failed to correlate with any host or tumour factors. In addition, median Ki67 values were not significantly different between irradiated tissue and non‐irradiated tissue, between sites nor between patients who did and did not later develop lymph‐node metastases. Of particular relevance is that Ki67 value did not correlate with survival. Data was further analysed using Cox's proportional hazards model for survival. Ki67 had no significant effect on survival. It is concluded that Ki67 index is of no value in predicting the course of squamous cell carcinoma of the head a

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01140.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The rising numbers of legal cases relating to delay in the diagnosis of acoustic neuroma, combined with the increasing availability of magnetic resonance, is increasing pressure on otologists to make an early definitive diagnosis of cerebellopontine angle tumours.Unilateral or asymmetrical otologic symptoms not explained by external or middle ear disease are elicited in 16.6% of 500 consecutive attenders to an otolaryngology clinic.An agreed policy of risk stratification of patients with unexplained asymmetric otological symptoms is required if expense is to be limited and litigation minimized.

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01141.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Between 1966 and 1984, 14 patients with carcinoma of the soft palate and eight patients with a posterior oropharyngeal wall carcinoma were treated at the Netherlands Cancer Institute.In the soft palate group, the majority of patients (10) had small tumours T1‐T2; the median patient delay was 1 month (range 0‐5). Eleven patients were treated with radiotherapy and three with surgery, as single treatment modalities. Tumour control was achieved in 10 patients following initial treatment. Five‐year results for tumour control and overall survival were 67% and 41%, respectively.In the posterior wall group all patients had advanced tumours (T3‐T4), after a median patient delay of 4 months (range 0‐6). Six patients were treated with radiotherapy, one with surgery only and one with a combination of these. Following the initial treatment, tumour control was achieved in half of the patients. Five‐year tumour control was 50%, and overall survival at 5 years was 38%.In conclusion, the tumours in these two sub‐sites of the oropharynx differ significantly in the extent of the primary tumour (P<0.01), posterior wall tumours being more advanced on admission, after a significantly longer his

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01142.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The first 100 consecutive free radial forearm flaps used in reconstruction for oral and pharyngeal cancer were investigated. Seven re‐operation took place due to circulatory impairment of the flap. Two flaps underwent partial, and four total necrosis, one of those patients died of massive haemorrhage, Post‐operative infection was significantly correlated to increased time between the last radiotherapy session and surgery. All but eight patients had post‐operative impairment of swallowing and all but five patients had impairment of speech articulation or hypernasality. Post‐operative time spent in hospital was a range of 12‐122 days (mean 37 days). The 2‐year survival rate was 70% and the 5‐year survival

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01143.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The presence of otitis media with effusion (OME) and high negative pressure (‐200 to ‐400 mm H2O)3were investigated in follow‐up of a randomized double‐blind placebo‐blind placebo‐controlled trial on the efficacyu of amoxicilin/clavulanic acid in the treatment of acute otitis media. All children in this study were recruited from a general practice population. Tympanometry results 1 month from the start of an episode of acute otitis media were taken as outcome criteria. Bilateral middle ear dysfunction was defined as bilateral OME, unilateral OME and contralateral or bilateral high negative pressure. Bilateral middle ear dyusfunction was present in 47.9% of the patients. Of all teh investigated factors of possible influence (age, sex, season, laterality of acute otitis media, therapy, and clinical course of acute otitis media), only season showed a statistically significant influence on the persistence of OME/high negative pressure (P = 0.001). Bilateral middle ear dysfunction was shown to be of prognostic value for the risk of a recurrence of acute otitis media (odds ratio 3.75). shown to be of prognostic value for the risk of a recurence of acute otitis media (odds

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01144.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

Snoring is a common disorder usually presenting to otolaryngologists. Most patients who have any nasal symptoms would normally be offered nasal surgery, but there is a significant incidence of failure to control the snoring (approximately 25%).We analysed a group of patients, all having nasal surgery for snoring, with the aim of assessing whether any pre‐operative factors would predict success of failure of the surgery. We found symptoms of excessively loud snoring, witnessed apnoeic episodes and hypersomnolence, or obstructive sleep apnoea diagnosed by overnight oxygen saturation measurements to be stateistically associated with failure of nasal surgery to improve snorin

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01145.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

The aim of this study was to derermine the role of histomine receptors in the nose. The effects of intranasal histamine challenge were compared with those of a specific HI‐receptor agonist, betahistine and a specific H2‐receptor agonist, impromidine, in 11 normal individuals and four with rhinitis. Sneezing, nasal irritation and hypersecretion were induced by histamine and the Hl‐receptor agonist, betahistine only. Nasal airway resistance (Rna) was measured by passive anterior rhinomanometry. Histamine, betahistine and impromidine all induced rises in Rna in both normal individuals and those with rhinitis but histamine had the most potent effect; the H2‐receptor effect on Rna was predominant over that of the Hl‐receptor. The sensitivity to all three agonists was greater in the individuals with

ISSN:0307-7772    

DOI:10.1111/j.1365-2273.1994.tb01146.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY