摘要:

AbstractProteins found in venoms, especially of theViperidaesnake family, exert, often with a narrow specificity, activating, inactivating, or other converting effects on different components of the hemostatic and fibrinolytic systems, respectively. Some purified snake venom proteins have become valuable tools in basic research and in diagnostic procedures in hemostaseology.“Procoagulant”as well as“anticoagulant”venom components have been identified inin vitrotest systems.“Procoagulant”snake venom components may causein vivo, upon massive application as in the case of snake-bite of small prey animals, intravascular coagulation leading to circulatory arrest and rapid death. Smaller doses of procoagulant venom components applied to large organisms as in the case of snake-bite accidents in humans, may cause a consumption coagulopathy with localized or generalized bleeding. Highly purified, specific fibrinogen coagulant venom proteinases are used in human medicine to produce therapeutic defibrinogenation. These practically nontoxic venom enzymes may act synergistically with other components aggravating their toxic effects.

ISSN:1040-8444    

DOI:10.3109/10408449109089878

出版商:Taylor&Francis    

年代:1991

数据来源: Taylor

ISSN:1040-8444    

DOI:10.3109/10408449109089879

出版商:Taylor&Francis    

年代:1991

数据来源: Taylor

摘要:

AbstractAn examination of the studies on therapeutic chelating agents that have been carried out during the last decade reveals that extensive efforts have been made to develop compounds superior to those previously available for the treatment of acute and chronic intoxication by many metals. These metals include primarily iron, plutonium, cadmium, lead, and arsenic, but also many other elements for which acute and chronic intoxication is less common. These studies have revealed the importance of several additional factors of importance in the design of such compounds and have led to many new compounds of considerable clinical promise. An additional development has been the introduction of previously developed chelating agents for use with certain metals on a broader scale.

ISSN:1040-8444    

DOI:10.3109/10408449109089880

出版商:Taylor&Francis    

年代:1991

数据来源: Taylor