ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewThe purpose was to summarize the findings of the proangiogenic clinical trials using protein and gene therapy, with analysis of the problems and an interpretation of the results.Recent findingsRecent findings include several new large clinical trials, using both gene and protein therapies. There has been development of new basic science concepts, especially with regard to endothelial activation and stabilization of newly formed microvessels. This review provides a critical analysis of the most recent clinical trials, both in efforts to understand the pitfalls of earlier clinical trials, and also to focus on requirements for future studies.SummaryThis article reviews many of the clinical trials utilizing proangiogenic therapy, assesses the pitfalls seen within the current trials, and discusses the conclusions drawn and the future of angiogenesis therapy.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewThis review discusses the current and future applications of different echocardiographic modalities in evaluating diastolic function intraoperatively.Recent findingsNormal diastolic function is required for optimal cardiac performance. There is sufficient evidence to support the significant prevalence of preoperative diastolic dysfunction and its incidence following cardiac surgery, however controversy still exists regarding the impact of diastolic dysfunction on adverse outcomes. Echocardiography provides a relatively safe, practical and noninvasive means to evaluate perioperative diastolic function, however conventional measures may be limited by the impact of changes in heart rate, rhythm and loading conditions. Newer echocardiographic modalities are reportedly less sensitive to acute changes in loading conditions, and may therefore complement the use of conventional echocardiographic techniques in the perioperative period.SummaryThe availability of effective technology for diagnosing the presence and progression of perioperative diastolic function should assist in the identification of high-risk cardiac surgical patients who may benefit from appropriate triaging and therapeutic intervention.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewDiscuss and summarize recent published literature related to the use of ‘blood substitutes’ in cardiac surgery patients.Recent findingsConcerns about safety, inventory and the cost of allogenic blood transfusion have led to the continued interest to find an ideal oxygen carrier ‘blood substitute’ for cardiac surgery patients. Two classes of oxygen therapeutics ‘blood substitutes’ are being investigated: (1) perfluorocarbons are synthetic fluorinated hydrocarbons which increase dissolved oxygen in the fluid phase and (2) hemoglobin-based oxygen carriers, modified to improve oxygen dissociation properties and side effects profiles of free hemoglobin. Hemoglobin-based oxygen carriers from bovine and human sources are being tested in phase III trials in cardiac surgery patients as well as a variety of other surgical and nonsurgical settings. Recombinant human hemoglobin and encapsulated hemoglobins of any source are emerging. Safety and cost effectiveness are being evaluated for their use as an alternative to blood transfusion or along with other strategies of blood conservation in cardiac surgery.SummaryOne hemoglobin-based oxygen carrier (Hemopure) has been approved for use in humans in South Africa as well as another hemoglobin-based oxygen carrier (Gelenpol) and a perfluorocarbon (Perfluoron) in Russia. Phase III trials in Europe and North America will be concluded very soon. We anticipate seeing one or two products approved in North America and Europe by the year 2003/2004.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewThe purpose of this review is to present developments in cardiopulmonary bypass circuitry, and to give the authors' opinions on the causes of the potentially harmful processes that are initiated by cardiopulmonary bypass, and how they may be attenuated.Recent findingsMuch of the recently published work investigates the effect of various forms of biocompatible circuitry, either heparin bonded, or polymer coated. The increasing number of patients having off-pump coronary surgery allows comparison of such patients with those that have had surgery using the various forms of cardiopulmonary bypass circuitry.SummaryRecent developments of biocompatible circuits are promising in terms of their potential for reducing the perioperative inflammatory response. The use of such circuitry, however, is likely to be of benefit only when included as part of an overall strategy to control triggers of the inflammatory response during and after cardiac surgery, particularly in the high-risk patient.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewRecent advances in technology as well as new indications for implantation have appeared in the field of ventricular assist devices. Progress has also been made in the understanding of the underlying mechanisms of myocardial recovery after ventricular assist device support.Recent findingsTechnological progress includes the development of fully implantable pulsatile and continuous flow pumps, either axial flow or centrifugal, for left ventricular and total heart assistance. Among the new indications for ventricular assist device support, the most important is the use of the device as permanent treatment for end-stage cardiac failure patients. Increased knowledge has been acquired regarding the effects of mechanical assistance and of unloading of the heart on haemodynamics, as well as on the cellular, molecular and electrophysiological characteristics of the failing heart. All these findings suggest that depressed myocardial function can sometimes recover with ventricular assist device therapy. Ventricular assist device support, however, still carries a high rate of complications: the device itself can fail, bleeding and thromboembolism are common, immunity is disturbed and the incidence of infection remains high.SummaryIn patients with end-stage heart failure, ventricular assist devices can be used as a bridge to transplantation or to recovery, but they are now also considered as a long-term myocardial replacement therapy. Which device is the most appropriate for each indication, however, remains to be defined. Even if the underlying mechanisms of myocardial recovery are progressively clarified, the use of ventricular assist devices as a bridge to recovery still has limited clinical success. Clinical trials with the fully implantable devices are in their early stages, but these pumps appear promising in terms of efficacy, reliability and complication rate, as well as being easy to implant. Because more patients will benefit from ventricular assist device placement in the future, anaesthesiologists must be prepared to manage patients undergoing ventricular assist device placement or presenting for noncardiac surgery while under ventricular assist device support.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewThe purpose of this review is to focus on the static incidence of renal dysfunction, the lack of evidence of benefit of traditional renoprotective strategies, and newer techniques that may provide an insight into the mechanisms of acute perioperative renal injury associated with vascular surgery.Recent findingsRecent studies that have investigated the long-term results of aortic surgery still report a significant incidence of postoperative renal dysfunction. This finding remains consistent in several reports. However, less invasive techniques such as endovascular repair seem to be associated with reduced inflammation and postoperative renal dysfunction. The possible association between genetic heterogeneity and renal dysfunction in vascular surgical patients is an exciting new area of research.SummaryRenal dysfunction after major vascular surgery remains a significant problem. New insights into the mechanisms of acute renal injury and less invasive techniques of vascular repair may help reduce the incidence of renal dysfunction in this patient population. The lack of a truly ‘renoprotective’ agent has hampered our efforts in preventing this major complication of vascular surgery.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewDisorders of the pulmonary circulation might develop as a primary disease process of the pulmonary vascular bed or, more often, as the acute or chronic consequence of pulmonary or cardiac pathologies. For the anaesthesiologist and intensivist it is particularly interesting to gain insight into the regulation of the pulmonary circulation since pulmonary hypertension and concomitant right heart failure contribute to high perioperative mortality rates in patients at risk, especially after cardiac surgery. Therefore, modulation of the pulmonary circulation may be a life-saving therapy in patients suffering from acute or chronic pulmonary circulatory disorders. Furthermore, routinely performed intra-operative interventions such as the use of volatile anaesthetics or cardiopulmonary bypass systems may have relevant side effects on the pulmonary circulation.Recent findingsThis review focuses on new insights into the modulation of pulmonary circulation during general anaesthesia with volatile anaesthetics and anaesthesiological management during cardiopulmonary surgery. Recent publications in the field of cardiopulmonary bypass surgery, one-lung ventilation and heart and lung transplantation are discussed. Furthermore, the role of conventional and experimental therapeutic strategies to modulate pulmonary circulation in intensive care medicine is reviewed.SummaryDespite the performance of a large number of clinical and experimental studies, the pathophysiology of pulmonary circulatory disorders is not completely understood. Therefore, any new therapy has to be carefully evaluated as a therapeutic option. Several formerly experimental therapeutic interventions such as inhaled vasodilators, however, appear to have found their way into clinical practice for selected indications.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Purpose of reviewTo familiarize anesthesiologists with recent advances in endoscopic pulmonary stenting. These interventions have replaced surgical procedures for the relief of central airway obstructions.Recent findingsA pulmonary stent can provide immediate relief of symptoms and improvement in pulmonary function for both intrinsic and extrinsic airway lesions. The current indications for the use of both silicone-rubber stents and expandable metal stents are reviewed. Considerations for the anesthetic management of patients undergoing pulmonary stent placement are also discussed.SummaryTracheo-bronchial stenting procedures are being employed with increasing frequency. The practicing anesthesiologist must be familiar with the management of patients undergoing airway stenting procedures.

ISSN:0952-7907    

出版商:OVID    

年代:2003

数据来源: OVID