1. |
New year, new challenges |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 1-2
Alberto Zanchetti,
Giuseppe Mancia,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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2. |
Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 3-12
Doron Aronson,
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摘要:
The normal aging process is often accompanied by arterial wall stiffening and by a decrease in myocardial compliance. These processes contribute to isolated systolic hypertension and diastolic heart failure, which lead to substantial morbidity and mortality among older individuals. Patients with diabetes manifest arterial stiffening and diastolic dysfunction at a younger age. This leads to the concept that the mechanism that underlies changes in vascular mechanical properties during aging is accelerated in diabetes. The Maillard reaction or advanced glycation of proteins occurs slowlyin vivowith normal aging and at an accelerated rate in diabetes. Advanced glycation end-products (AGEs) that form during the Maillard reaction are implicated in the complications of aging and diabetes. The formation of AGEs on vascular wall and myocardial collagen causes cross-linking of collagen molecules to each other. This leads to the loss of collagen elasticity, and subsequently a reduction in arterial and myocardial compliance. Aminoguanidine, an inhibitor of AGE formation, is effective in slowing or preventing arterial stiffening and myocardial diastolic dysfunction in aging and diabetic animals. In aged and diabetic animals, agents that can chemically break pre-existing cross-linking of collagen molecules are capable of reverting indices of vascular and myocardial compliance to levels seen in younger or non-diabetic animals. These studies suggest that collagen cross-linking is a major mechanism that governs aging and diabetes-associated loss of vascular and cardiac compliance. The development of AGEs cross-link breakers may have important role for future therapy of isolated systolic hypertension and diastolic heart failure in these conditions.
ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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3. |
What defines an adolescent as having hypertension? |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 13-14
Barry Materson,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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4. |
X-linked quantitative trait locus for susceptibility to renal injury |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 15-17
Yoshio Uehara,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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5. |
Genetic influences in human hypertension |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 19-22
Peter Rutherford,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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6. |
The world of endothelin in the brain of the stroke-prone spontaneously hypertensive rat |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 23-25
Yoshio Uehara,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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7. |
Endothelin-dependent modulation of vasoconstrictor action in the coronary circulation in early salt-induced experimental hypertension |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 27-29
Hans-Dieter Orzechowski,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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8. |
Omapatrilatstill a promise in salt-sensitive hypertension? |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 31-32
Akihiro Tojo,
Toshiro Fujita,
Christopher Wilcox,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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9. |
Sodium intake and vessel wall properties of large arteries |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 33-35
Michael Barenbrock,
Markus Kosch,
Martin Hausberg,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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10. |
Renal dopamine receptors and hypertension |
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Journal of Hypertension,
Volume 21,
Issue 1,
2003,
Page 37-38
Albert Ferro,
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ISSN:0263-6352
出版商:OVID
年代:2003
数据来源: OVID
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