摘要:

Within the last 10 years we have studied 31 patients, 3 with purpura fulminans, 17 with meningococcal sepsis, and 11 with hemolyticuremic syndrome, who showed evidence of or were suggestive for disseminated intravascular coagulation (DIC). We have administered anticoagulant therapy to all of them. In purpura fulminans the presence of DIC and therapeutic effectiveness of heparin were undoubted. In meningococcal sepsis, in vitro study suggests evidence of DIC to a certain extent, but the benefit of heparin, at first sight, appears to be doubtful. By surveying our overall mortality in meningococcal infections, however, early heparinization of patients with severe fulminant meningococcemia, in particular those with shock, is definitely indicated. In hemolytic-uremic syndrome the in vitro coagulation studies are inconclusive and only indirect evidence of DIC can be demonstrated. The value of heparin, and perhaps the addition of activators of fibrinolysis, in this disorder is disputable

ISSN:0001-5792    

DOI:10.1159/000208601

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

In an autoradiographic investigation, it was found that the inhibition of RNA synthesis in human leukaemic blast cells by actinomycin D (AMD) is dose and time dependent. Chase studies with AMD showed that most of the rapidly labelled RNA is unstable. The decay pattern is biphasic, being most rapid in the initial 30–60 min and much slower thereafter. Long-lived templates for protein synthesis were not revealed by the present stu

ISSN:0001-5792    

DOI:10.1159/000208602

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

On 6 patients suffering from rubeola or morbilli we examined the portion of IgG-containing cells and the number of DNA-synthesizing lymphocytes repeatedly during the course of the disease using immunofluorescent and autoradiographic methods. In virus infections we found a marked increase of both cellpopulations by comparison with normals. During the course of the disease we observed a simultaneous increase and decrease of both IgG-containing and DNA-synthesizing lymphocytes. At the beginning of that reaction, DNA-synthesizing cells prevailed upon IgG-positive cells. In 2 cases, a small portion of IgG-containing cells was found to be in the stage of DNA-synthesis

ISSN:0001-5792    

DOI:10.1159/000208603

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

By a simple cytochemical method for the de- monstration of lysozyme (muramidase) activity, more than 95 % of human- and rat-blood monocytes could be identified and differentiated from lymphocytes. Peroxidase activity was seen in 83–88 % of the monocytes. When a staining method for lysozyme and peroxidase activity in the same cell was used, most blood mononuclear cells showed neither or both kinds of enzyme activity. Of the rat mononuclear cells, 6.9 % showed peroxidase activity alo

ISSN:0001-5792    

DOI:10.1159/000208604

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The submicroscopic morphology of blood and bone marrow elements in a patient with plasma ceil leukemiaBence Jones proteinuria (type K) and hypogamma-globu- linemia is described. Highly undifferentiated cells were rarely seen and tentatively called blast cells. Two other cell types Plasma cell leukemia with a more complex ultrastructural organization ressemble the ‘intermediate’ lymphocytes and the plasmacytic elements and probably represent different functional stages of the same cell. In particular the absence of large polyribosomes and of dilated ergastoplasmic cisternae, and the presence of small polyribosome rosettes formed by 5–10 ribosomes, are correlated with the hypogammaglobulinemia and with the high L chain synthesis in this p

ISSN:0001-5792    

DOI:10.1159/000208605

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The morphological transformations of the early stages of glass-contact haemolysis of normal human red cells are described

ISSN:0001-5792    

DOI:10.1159/000208606

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The splenogram, myelogram and quantitative data on the bone marrow and spleen of 2 strains of mice are presented. Using 2 techniques, the absolute numbers of dif- ferent cells per mg of bone marrow and per femur are determined. The results are discussed with respect to the quantitative evaluation of the whole body haemopoietic tissue in mice

ISSN:0001-5792    

DOI:10.1159/000208607

出版商:S. Karger AG    

年代:1971

数据来源: Karger