ISSN:0001-5792    

DOI:10.1159/000207359

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Bovine serum albumin bound 14C-palmitic acid (BSA-14C-PA) is transported into platelets of normal and cirrhotic subjects by simple diffusion. Initial uptake increases linearly with the concentration of BSA-14C-PA in the medium. The time course accumulation of BSA-14C-PA is found to be higher in the platelets of patients with cirrhosis compared to that of normals. At 50-min incubation, the amount of 14C-PA accumulated in the platelets of cirrhotic subjects is 52.43 ± 7.40 nmol/109 platelets and in the platelets of normal controls it is 22.71 ± 3.14 nmol/109 platelets. The diffusion rate of BSA-14C-PA is also higher in the platelets of cirrhotic patients where the slope of the concentration dependency curve for 109 platelets at 30 sec is 56.0 ± 4.8 × 10-4 liters. This value is 21.6 ± 2.4 × 10-4 liters for normal sub

ISSN:0001-5792    

DOI:10.1159/000207360

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Normal levels of NADH-cytochrome b5 reductase activity in platelets, lymphocytes and granulocytes were determined. The homogenate of each cell was treated with Triton X-100 after incubation with lipoprotein lipase. The reductase was extracted very well from the cells by this treatment. Moreover, the assay of the reductase activity in the cells became accurate and reproducible by the treatment. The reductase level of each cell was also determined in cases of hereditary methemoglobinemia. It was normal in the case of the disease without mental retardation, and low with mental retardation. This latter case might be due to the deficiency of cytochrome b5 reductase in the whole tissue.

ISSN:0001-5792    

DOI:10.1159/000207361

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

In 10 patients with rheumatoid arthritis, with normal baseline granulocyte count, the etiocholanolone test showed a decrease in the bone marrow granulocyte reserve; factors causing such a defect are discussed.

ISSN:0001-5792    

DOI:10.1159/000207362

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

223 cases with chronic lymphoid leukemia (CLL) were subjected to a prospective study on the presence of adeno- and splenomegaly at diagnosis and their subsequent variation. Subjects with no initial organ involvement were usually female (76%) and of old age (mean 69.2 years). Adenopathy or combined lymph node and spleen enlargement were inversely proportional to the mean age at diagnosis. Subsequent organ enlargement was noted in 11.7% of patients with no initial organomegaly, splenomegaly in 15% of patients with adenopathy only and adenopathy in 15% of patients with splenomegaly only. Except in the few cases with leukopenia, particularly high leukocyte levels were noted in patients with splenomegaly (with or without adenopathy). Anemia at diagnosis was not related to the degree of organ enlargement. It is suggested that qualitative and also quantitative differences in organomegaly in CLL merit further study to establish their underlying mechanisms. CLL must be seen as something more complex than the simple mechanical expression of progressive lymphocyte accumulation.

ISSN:0001-5792    

DOI:10.1159/000207363

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

In this study the case of a child affected with hereditary spherocytosis, who presented with a presumably viral infection induced transient aplastic crisis, is described. The bone marrow aspirate showed phagocytosis of erythrocytes and nucleated cells by reticular cells. The possible pathogenetic role of bone marrow phagocytosis in aplastic crises in patients with haemolytic anaemias is discussed.

ISSN:0001-5792    

DOI:10.1159/000207364

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

88 adults with thalasseia-like red cell indices, normal serum iron and normal hemoglobin (Hb) A2 and F levels, diagnosed in a mass screening had Hb H inclusion bodies studies (65 subjects) or Hb H inclusion bodies studies and globin chain synthesis analysis (23 subjects). The α/β ratio of 0.70 + 0.10 was the same as in obligate α-thalassemia-1 (α-thal) carriers. Hb H inclusion bodies studies were found to be a reliable test for α-thal trait identification, resulting positive in approximately 70% of suspected carriers. The α-thal carrier defined by Hb H preparation or by globin chain synthesis had significant reduction in the mean Hb level, hematocrit, mean corpuscular hemoglobin and a significant increase in mean red cell count, but there was some overlap with con

ISSN:0001-5792    

DOI:10.1159/000207365

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The unusual occurrence of both β°-thalassemia and autoimmune hemolytic anemia (AIHA) in a 28-month-old child is reported to illustrate special diagnostic and therapeutic studies. The diagnosis of β°-thalassemia was established by clinical, family and globin synthesis studies. The diagnosis of AIHA was confirmed by the shortened survival of transfused autologous and homologous red blood cells and by positive direct antiglobulin tests. During treatment of the AIHA with corticosteroids and various immunosuppressive drugs, globin synthesis studies were performed to evaluate the coincidental effects on γ/α-globin chain synthetic ratios. A 50% increase in the γ/αsynthetic ratio during cyclo-phosphamide treatment suggests that further studies of the possible benefits of cytotoxic drug therapy in β-tlassemia may be i

ISSN:0001-5792    

DOI:10.1159/000207366

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

Two families from southern India with members having the clinical manifestations of thalassemia intermedia are presented. Hematologic and globin chain synthesis data indicated that in one family the affected brother and sister had the β+- δ° β°-thalassemia condition while in the other family the propositus was homozygous for a β°-thalassemia deter

ISSN:0001-5792    

DOI:10.1159/000207367

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

We describe an unusual case displaying the features of double monoclonal gammapathy (IgM-kappa plus IgG-lambda) associated with non-Hodgkin lymphoma (NHL). In the last years monoclonal gammapathies have been sometimes found to be associated with NHLs; it is a very peculiar occurrence the association between a different class double monoclonal gammapathy and NHL, as the case reported in this paper.

ISSN:0001-5792    

DOI:10.1159/000207368

出版商:S. Karger AG    

年代:1980

数据来源: Karger